Indianapolis Colts vs. Tennessee Titans: Prediction, Odds, Depth Charts (12/3/23)

The Indianapolis Colts travel to Tennessee this weekend to take on the Titans in an AFC South showdown with playoff implications. Let’s take a look at Colts vs. Titans odds and predictions as Tennessee looks to snap Indianapolis’ win streak, with Titans moneyline (-102) our best bet.

Colts vs. Titans Prediction

Colts vs. Titans prediction: Titans Moneyline (-102)
Nothing from the Titans’ offense over the last handful of weeks has inspired much confidence, outside of the fact Will Levis is limiting turnovers much better than Ryan Tannehill did. That’s helpful – it allows Tennessee to win defensive battles it might not have before – but will it be enough against the Colts?

Interestingly, the Titans are 4-0 in Nashville this season. They’ve picked up some convincing wins at home, while the road has not treated them nearly as well. One of Tennessee’s road losses came at Indianapolis, when the Titans let Zack Moss run all over them.

The defense handled Gardner Minshew well in that game. A run defense that has otherwise been pretty solid of late should be able to quiet Moss a bit, especially with Jonathan Taylor out and Moss the known feature back. Last time, Taylor was active but more of a decoy as he was getting up to speed.

The turnover battle might decide this one, as Minshew has thrown seven interceptions over his last six games but the Colts’ defense has helped offset those troubles by forcing turnovers of their own. Levis has taken care of the ball well, particularly at home, and more of the same should give the Titans the upper hand on Sunday.

Colts vs. Titans Best Odds

The Colts are 1-point road favorites, entering at -120 on the moneyline. The over/under is 42.5 points.

Indianapolis has remained steady as a slight favorite after taking care of business against the Buccaneers last weekend. The Titans got back in the win column against the Panthers, but a choppy offensive showing kept them from entering this game even or favored.

Colts vs. Titans Key Injuries

The Colts will be without RB Jonathan Taylor in Week 13 after he suffered a thumb injury vs. Tampa. Meanwhile, DT DeForest Buckner (shoulder) appears to be on track to play while C Ryan Kelly has missed time with a concussion but returned to practice full-time ahead of Sunday’s game.

For the Titans, QB Will Levis has been dealing with an ankle injury but is fully expected to play. WR Treylon Burks (concussion) has returned to practice and could play against the Colts.

Colts vs. Titans Key Matchups

Here are some of the key matchups that could decide Colts vs. Titans.

Zack Moss vs. Titans Run Defense

Jonathan Taylor looked like his old self in last week’s win over the Buccaneers, but he left with a thumb injury that will keep him out for at least a couple of weeks. That means the Colts will turn back to Zack Moss, who was putting together a career year when Taylor was either off the field or still getting up to speed.

Moss is averaging a terrific 4.8 yards per carry, with 672 yards and five touchdowns under his belt this season, and he had two games of 100+ rushing yards earlier in the season. His best came against Tennessee: 165 yards and two touchdowns. The Titans have some issues elsewhere on their defense, but the run defense has allowed just 3.8 yards per attempt this season and held their opponent’s top running back to less than four yards per carry in each of the last three weeks.

If the unit can limit Moss, who torched them in September, Tennessee will have a much easier path to keeping Indianapolis’ offense at bay.

Will Levis vs. Turnovers

Will Levis, to this point, has won the battle vs. turnovers. He’s thrown only two interceptions in five starts this season, with a fumble as the only other turnover in his brief NFL career. A clean game is what allowed the Titans to hang on and win against Carolina in what otherwise wasn’t the most encouraging offensive performance. Can Levis take care of the ball against the Colts as well?

Indianapolis has forced a turnover in all 11 games this season, with multiple turnovers forced in more than half of their games. Gardner Minshew has dealt with turnover troubles at times, but the defense returning the favor and getting the ball back in his hands has helped offset those problems in key games.

If Levis can take care of the football like he has for the most part this season, the Titans can hang with the Colts.

Indianapolis Colts Depth Chart

QB: Gardner Minshew
RB1: Zack Moss
RB2: Jonathan Taylor
LWR: Michael Pittman Jr.
RWR: Alec Pierce
SWR: Josh Downs
TE1: Kylen Granson

Titans Depth Chart

QB: Will Levis
RB1: Derrick Henry
RB2: Tyjae Spears
LWR: Treylon Burks
RWR: DeAndre Hopkins
SWR: Nick Westbrook-Ikhine
TE1: Chigoziem Okonkwo

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Dan is a lifelong sports fan and graduate of Boston University. He’s covered several sports on Instagram since he was 12 and now writes about everything from betting trends to breaking news for Lineups.

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