Dallas Cowboys vs San Francisco 49ers Preview (1/22/23): Betting Odds, Prediction, Depth Chart

It’s the Divisional rounds Sunday main event as the Dallas Cowboys take on the San Francisco 49ers in what will be a thrilling defensive slugfest. Both hailed as some of the most feared defenses in the league, while also boasting dynamic offenses that have propelled them to early high scoring playoff victories. Both defenses will need to be firing on all cylinders to limit each other’s production. Get your popcorn ready NFL fans, this will be a fun one.

Dallas Cowboys vs San Francisco 49ers Betting Odds

As for who will come out on top? Oddsmakers believe the 49ers have the edge in this one as they opened as a -4.5 favorite. Bettors believe that number opened way too high, bringing it back towards near the key number of 3 by backing the Cowboys down to +3.5 in some shops as of writing. This brings some intrigue as Dak Prescott played a near perfect game through the air, dismantling the Buccaneers defense. He now gets a similar elite style defense in the 49ers, one that will be sure to bring pressure and cause Havoc through the air.

As for the total, points are expected to be scored at a moderate pace as oddsmakers opened the total at 46.5. With two elite defenses taking the field, bettors are leaning towards the under by taking the total down to as low as 45.5. This is an immediate stay away as game flow will dictate how this pace is played. While the Cowboys can hit an explosive play in a heartbeat, the 49ers will prefer to play a more conservative approach by making small mistake free gains at a time.

Dallas Cowboys vs San Francisco 49ers Prediction

The Pick: Cowboys +4

This is arguably going to be the best game of the slate, one that I believe will come down to who has the ball last. With that said, I will back the Cowboys at +3.5 or higher as I believe they have the style of offense to constantly move the ball against the 49ers defense while also limiting their offensive production with an elite defense themselves. Let’s just hope the cover doesn’t come down to a Brett Maher kick.

Jokes aside, this Cowboys offense has been firing on all cylinders as Dak got more acquainted since his injury. When throwing a turnover free game, the Cowboys looked near unstoppable as they picked apart the Bucs defense. They have elite weapons on both the outside and the backfield, constantly keeping defenses reeling. It won’t be easy against the number one defense per Overall Def DVOA, but their versatility makes them more than capable of sustaining down field success.

Especially through the air, an area that the 49ers “lack at” in comparison to their ability to limit the run. Tony Pollard’s dual threat ability will be crucial here as he can punish the linebackers for stacking and pressing through the middle.

Betting Trends

  • Over is 8-3 in their past 11 meetings against each other
  • Road team is 4-1-1 ATS in their last six meetings

Key Injuries

Dallas Cowboys Injuries: Jason Peters (Q), Jayron Kearse (Q), Trayvon Mullen (Q)

San Francisco 49ers Injuries: Samson Ebukam (Q), Jauan Jennings (Q)

Key Matchups

Can the Cowboys defense limit the 49ers pass attack?

Brock Purdy vs Cowboys secondary

One of the more feel good stories of the season, Mr Irrelevant Brock Purdy has been electric since his time under center. He has continued to lead an efficient pass attack with the 49ers ranking third in Off Pass DVOA.

The Cowboys secondary has ranked identical in terms of pass coverage, proving the ability to disrupt Purdy’s rhythm through the air. Better yet, the Cowboys excel in blitz schemes by sending Parsons crashing down the line and getting to the quarterback.

Should they generate Havoc and flip the field, the Cowboys will be in prime position to get the upset victory. 


Back the Cowboys at +3.5 or higher as their versatility on offense can keep the 49ers defense reeling while their own defense can shut down Brock Purdy’s pass attack.

Dallas Cowboys Depth Chart

QB: Dak Prescott
RB1: Ezekiel Elliott
RB2: Tony Pollard
LWR: CeeDee Lamb
RWR: Michael Gallup
SWR: TY Hitlon
TE1: Dalton Schultz

San Francisco 49ers Depth Chart

QB: Brock Purdy
RB1: Christian McCaffery
RB2: Elijah Mitchell
LWR: Deebo Samuel
RWR: Brandon Aiyuk
SWR: Jauan Jennings
TE1: George Kittle

Kody is a sports betting writer here at Lineups. Residing in Northern MI his whole life, he graduated from GVSU with a Bachelors in Finance but quickly set his sights on the sports betting industry. He started his career contributing for The Action Network, covering NCAAF/NCAAB/and NFL. Born into Detroit Lions fandom, he knows nothing but pain and false optimism while repetitively telling himself this is our year. That is until they win the Super Bowl this year.

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