Green Bay Packers vs. Buffalo Bills Preview (10/30/22): Betting Odds, Prediction, Depth Charts

The Packers head to Western New York in search of a win following a three game losing streak. So who better to go up against than the 5-1 Super Bowl favorite Buffalo Bills? The Bills will face the Packers fresh off a bye and on the weekend’s biggest stage–Sunday Night Football. Let’s take a look at the odds and injuries to see who will prevail in the Rodgers-Allen battle.

Green Bay Packers Vs. Buffalo Bills Betting Odds


The Buffalo Bills are favored an enormous (-10.5) versus the Green Bay Packers (+10.5). It’s doubtful that before the season anyone would’ve predicted such a large spread for these two 2021 playoff teams, but the Packers three game losing streak has their outlook trending downhill. The over/under is set at 47.5.

Green Bay Packers Vs. Buffalo Bills Prediction

Aaron Rodgers and the Packers have lost their magic the past three weeks. Once the unquestioned kings of the NFC North, it’s now in question whether they’ll even have a chance at a playoff spot. During their three losses, the Packers have shown little of the potent passing attack that got them to three consecutive 13 win seasons. Their offense lacks weapons out wide, and even their best players in QB Aaron Rodgers and RB Aaron Jones are failing to produce. Defensively, the Packers hope OLB Rashan Gary will be able to play after suffering a concussion last week. Gary leads the team in sacks and has been the most consistent player on the Packers defense.

Meanwhile, everything is right on track for the Bills to make their deepest playoff push yet. The Bills got revenge on the Chiefs after last year’s devastating playoff loss with a week 6 win before heading into their bye week. Josh Allen looks like the favorite to win MVP, and before his bye week, he had more total yards than 25 teams in the league. Even with the bye, Allen still ranks 5th in passing yards, 2nd in passing touchdowns, and #1 in quarterback hurdles.


Von Miller and the Bills defense have played just as stout as their #1 offense, and are the league leaders in defensive yards allowed, rush yards allowed, and points allowed. It’s going to be tough sledding for the Packers to try and rebound against this fierce and complete team.

I’m picking the Bills to win at home and extend the Packers losing streak to 4. The Bills are miles ahead of most of the NFL, and certainly on a much better track than the Packers, who desperately need to turn things around.

Prediction: Bills 33-20, Over hits.

Betting Trends

  • Packers are 1-4 ATS in their last 5 games following a straight up loss
  • Bills are 10-1-2 ATS vs. a team with a losing record

Packers vs Bills Key Injuries

Green Bay Packers Injuries: Allen Lazard (Q), David Bakhtiari (Q), Christian Watson (Q), Krys Barnes (Q), Rashan Gary (Q), Randall Cobb (Q), Jake Hanson (O), Tipa Galeai (O)

Buffalo Bills Injuries: Jake Kumerow (Q), Ike Boettger (Q), Spencer Brown (Q), Tre’Davious White (Q), Jamison Crowder (O), Xavier Rhodes (Q)

Packers vs Bills Key Matchups

Packers Offensive Line vs the Bills Defensive Front

The Packers offensive line has been one of the team’s better units despite playing without David Bakhtiari recently. They did a great job allowing 0 sacks to the Commanders defensive front, and have allowed 15 sacks all season, which is middle of the league. Green Bay’s run blocking has certainly been questionable however, having rushed for a putrid 38 yards versus the Commanders. Their run game is in the bottom half of the league, and even with good protection Aaron Rodgers doesn’t have enough open receivers to throw to. The Bills defensive line led by Gregory Rousseau and Von Miller will look to challenge the Packers upfront and get to Rodgers often.

Bills Receiving Corps vs Packers Secondary

If the thought of stopping QB Josh Allen was scary enough on its own, good luck defending bombs to Stefon Diggs and Gabe Davis. Diggs and Davis have been one of the best WR duos of the season, and the Bills also have a bevy of receiving weapons,with TE Dawson Knox, WR Isaiah McKenzie, and week 5 standout Khalil Shakir. Diggs also comes off back to back 100 yard games before heading into the bye.
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The Packers #1 pass defense will be tasked with handling all these weapons. However, this stat may be misleading as CB Jaire Alexander had a hard time keeping up with WR Terry McLaurin and allowed a 37 yard touchdown catch, while CB Eric Stokes has struggled. The Bills will only provide a greater challenge to the Packers secondary.

Green Bay Packers Depth Chart

QB: Aaron Rodgers
RB1: Aaron Jones
RB2: A.J. Dillon
LWR: Romeo Doubs
RWR: Randall Cobb
SWR: Allen Lazard
TE1: Marcedes Lewis

Buffalo Bills Depth Chart

QB: Josh Allen
RB1: Devin Singletary
RB2: Zack Moss
LWR: Gabriel Davis
RWR: Stefon Diggs
SWR: Isaiah McKenzie
TE1: Dawson Knox

A UCLA graduate, Eva is an experienced football writer who specializes in NFL game analysis and weekly storylines. In her free time you can usually find her cheering on the 49ers or watching the latest Josh Allen highlight clip.

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