NFL Week 12 Odds and Lookahead Lines: Four Bets to Make This Weekend

Get a jump on NFL Week 12 odds & lookahead lines, along with four bets to place before lines begin to move for next week. Find updated NFL Week 12 odds below.

Week 12 NFL Odds & Lines

Lookahead NFL odds & Lines for Week 12

NFL Week 12 Betting Picks

The NFL has already been thrown off its track again by an injury to Bengals QB Joe Burrow. As injuries affect some of the league’s biggest contenders, how will the outlook change for certain teams?

Let’s take a look at the early Week 12 odds and which bets to place early.

San Francisco 49ers (-4.5) vs. Seattle Seahawks

The 49ers made quick work of the Seahawks three times last season, beating them at home and on the road. If San Francisco builds on last week’s blowout of the Jaguars and proves its losing streak is well in the rearview mirror, this line could move closer to 6 or 7 points knowing the way the ‘Niners have played against Seattle in the not-too-distant past.

The Seahawks didn’t look convincing against the Ravens earlier this month, and narrow victories over teams not quite in the playoff picture beg the question of whether Seattle is built to hang with teams as loaded as the 49ers.

The Seahawks also go on the road to face a Rams team that beat them in Week 1, with both top receivers now healthy and Matthew Stafford recovered from a thumb injury. Another less than inspiring performance could serve as another reminder of the gap between these two teams ahead of their Thanksgiving matchup.

Denver Broncos (-1) vs. Cleveland Browns

Oddsmakers still seem to be lagging behind on the Broncos. No, the offense isn’t perfect, but Russell Wilson isn’t making nearly as many mistakes as last season and the defense has totally transformed its level of play from the early weeks of the season. While the unit isn’t as dominant as the Browns’ defense, Wilson gives the Broncos a distinct advantage over a Browns team that will be led by either Dorian Thompson-Robinson or P.J. Walker.

On the road against a team that knows it has a real shot at a playoff berth all of a sudden, it’s fair to be skeptical about whether the Browns can score enough to win this game. If Thompson-Robinson struggles against a tough Steelers defense this weekend, the Broncos are going to become more decisive favorites here.

Miami Dolphins (-6) vs. New York Jets

The Jets have an excellent defense, but if the Bills can get back on track and win by a touchdown or more against New York this weekend, what’s stopping the Dolphins from doing the same?

Buffalo has too much talent offensively to play as poorly as it has in recent weeks, and the firing of OC Ken Dorsey should ignite a greater sense of urgency for the unit. Josh Allen has also been the victim of some poor luck, which is bound to change at some point. With the Jets’ offense in shambles and frustration likely mounting within the team, it wouldn’t be surprising to see New York take a more decisive road loss this week.

The Dolphins, meanwhile, are set to coast to a victory over the Raiders, who just earned a win over the Jets. Anything under a touchdown is a fine value for the Dolphins right now.

Washington Commanders (+9.5) vs. Dallas Cowboys

I’m not sure how much line movement we can get here, considering the Cowboys should be able to manage a relatively painless win over the Panthers in Week 11, but the Commanders’ offense has been impressive enough that it’s not impossible for Washington to hang with Dallas on Thanksgiving.

Sam Howell has learned how to get rid of the ball in recent weeks, taking only seven sacks over his last three games after averaging more than five per game, and he’s thrown for 300+ yards in each game over that stretch.

Washington has had a hard time winning because of its poor defense, but a matchup with the Giants should bring a victory this weekend. The Commanders’ defense will likely be their downfall on Thanksgiving, but Howell and the offense have shown enough that the margin might not be 10+ points on a short week for the Cowboys’ defense. It’s possible a Washington win over the Giants narrows this line slightly.

Dan is a lifelong sports fan and graduate of Boston University. He’s covered several sports on Instagram since he was 12 and now writes about everything from betting trends to breaking news for Lineups.

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