NFL Week 18 Odds and Lookahead Lines: Four Bets to Make This Weekend

Get a jump on NFL Week 18 odds & lookahead lines, along with four bets to place before lines begin to move for next week. Find updated NFL Week 18 odds below.

Week 18 NFL Odds & Lines

Lookahead NFL odds & Lines for Week 18

NFL Week 18 Betting Picks

The regular season reaches an end in Week 18, with several games set to have playoff implications. Some could be impacted by teams resting key starters, which makes betting decisions even more volatile than an ordinary week.

Let’s take a look at which NFL bets to lock in early for Week 18.

Houston Texans Moneyline (+104) vs. Indianapolis Colts

There’s a good chance both of these teams are playing for something in Week 18, even if they happen to be eliminated from AFC South contention. For the Texans, Week 17 could serve as an opportunity to restore some credibility in the eyes of oddsmakers.

Houston has been a much different team without C.J. Stroud, which is no surprise. Missed time for Nico Collins has also hurt the offense, but he’s now back up and running along with Stroud. If Stroud can step in and take advantage of a very manageable matchup with the Titans, this line may become a bit more even — especially if the Colts’ struggles against the Falcons lead into a tough battle with the pesky Raiders.

Jacksonville Jaguars (-2.5) vs. Tennessee Titans

Plenty has gone wrong for the Jaguars over the last month, and it’s possible Jacksonville gets into another slog this weekend without Trevor Lawrence. Still, positive news about Trevor Lawrence’s availability could lead to more confidence in this team. Lawrence was able to practice a bit late this week before being ruled out, so he should be ready to go if this game means something for the Jaguars.

The most likely scenario is that Jacksonville is still fighting for an AFC South title in this game, and all hands will be on deck if that’s the case. The Titans should have Will Levis back for this game, but the offensive line looks like it’s checked out and could be in for a long day against Josh Allen and a surging Travon Walker. Banking on Lawrence playing and the Jaguars winning by at least a field goals feels like the safe play early on.

Pittsburgh Steelers (+3.5) vs. Baltimore Ravens

This line can move simply because the Ravens might opt to sit key starters across the board. Baltimore just needs a home win over the Dolphins to lock up the No. 1 seed in the AFC, and while two full weeks off for Lamar Jackson and other critical pieces might not be an ideal scenario, it’s probably the Ravens’ best option when the alternative is risking injury in a meaningless Week 18 game.

The Steelers already showed this season that they know how to handle Jackson and keep games competitive against the Ravens, and Pittsburgh will likely be playing for something on the final day of the season even with a loss in Week 17, as it would take a comprehensive scenario to knock them out of contention, but the Steelers figure to be playing with the same pieces regardless. The Ravens might not, and Pittsburgh’s defense is good enough to handle business or at least stay competitive against a shorthanded Baltimore team looking ahead.

San Francisco 49ers (-7) vs. Los Angeles Rams

This line is totally up in the air because one, both, or neither of these teams could be playing for something in Week 18. In all likelihood, the 49ers will have to play their starters. They can only clinch a first-round bye with a win and an Eagles loss this week, and a Philadelphia loss is highly unlikely at home against Arizona.

The Rams have looked terrific of late, but between the 49ers’ greatness at home and the possibility that Los Angeles sits starters, this line is worth a close look. The Rams simply need a win over the Giants and a Seahawks loss to the Steelers to clinch in Week 17. A win is likely.

A Seahawks loss is a near toss-up, but the Steelers’ offensive resurgence with Mason Rudolph at quarterback certainly puts that possibility on the table. As long as the 49ers are truly motivated to get the bye – and they should be – a win by 7+ points is attainable.