NFL Week 6 Odds and Lookahead Lines: Four Bets to Make This Weekend

Get a jump on NFL Week 6 odds & lookahead lines, along with four bets to place before lines begin to move for next week. Find updated NFL Week 6 odds below.

Week 6 NFL Odds & Lines

Lookahead NFL odds & Lines for Week 6

NFL Week 6 Betting Picks

Week 5 already brought an upset with the Bears winning their first game in nearly a year. More surprises on Sunday and Monday could cause some major shifts in some Week 6 lines.

Let’s take a look at the early Week 6 odds and which bets to place early.

Seattle Seahawks Moneyline (+120) vs. Cincinnati Bengals

You can tell oddsmakers are quickly losing faith in the Bengals as Joe Burrow’s calf injury lingers and the offense lags behind. Cincinnati is only favored by 3.5 points against the Cardinals, who have played hard early in the season but should have a huge talent disadvantage in that matchup.

If the Bengals do get into a scrappy, ugly game with the Cardinals – entirely possible given how hard that team plays – we might see this Week 6 line even out a bit.

The Seahawks look ferocious defensively all of a sudden, and their offense has the advantage over Cincinnati’s as long as Burrow is dealing with the injury. Seahawks +2.5 or Seahawks moneyline (+120) both look like strong early values.

Houston Texans Moneyline (-104) vs. New Orleans Saints

Oddsmakers are still catching up to C.J. Stroud. The rookie has been playing very well despite a beaten up offensive line, and that line is starting to get healthier as of Week 5. If Stroud and the Texans’ offense outduel the Falcons in Week 5, they’re going to create some more believers.

The Saints haven’t played one clean, comfortable game this season, and it’s tough to play that kind of game in Foxborough this week. The worry with Derek Carr is that the Saints might be looking at a Joe Burrow situation, putting a less effective QB on the field so he can play through an injury.

Carr didn’t look right in Week 4, and if he again doesn’t seem 100 percent in New England, Stroud and the Texans are going to look like a much safer bet at home, where they’re currently slight underdogs for this matchup.

Indianapolis Colts (+4.5) vs. Jacksonville Jaguars

The Jaguars have looked less than stellar since Week 1, when they earned a solid but certainly not dominant win over the Colts. Since then, Anthony Richardson has gotten more comfortable as an NFL quarterback and Jonathan Taylor has returned to the Colts with a new contract in hand.

Which version of Jacksonville’s defense will show up in this game? The Jaguars performed well against the Falcons and Chiefs but couldn’t touch C.J. Stroud in between. If Jacksonville gets its doors blown off by the Bills in London, this Colts team that is playing hard and seems to keep getting better will be an attractive pick in a building that doesn’t offer the Jaguars a serious home-field advantage.

Dallas Cowboys (-2.5) vs. Los Angeles Chargers

This line is hovering right near a field goal, and it’s entirely possible it pushes past a field goal leading into Week 6 even with the Chargers on a bye week. It all rests on your view of the Cowboys’ chances against the 49ers.

San Francisco hasn’t faced a team as complete as Dallas this season, and while the 49ers have given them a hard time over the past two years, this is a Cowboys team that has totally walloped three of its four opponents this year. With both sides of the ball impressing against the Patriots, I wouldn’t put it past Dallas to win or at least hang right there with the 49ers on the road.

The Chargers don’t have much of a home-field advantage at SoFi Stadium and have tried hard to give away both of their two wins. The Vikings and Raiders let them off the hook. The Cowboys won’t and can without a doubt win by 3+ in LA.

Dan is a lifelong sports fan and graduate of Boston University. He’s covered several sports on Instagram since he was 12 and now writes about everything from betting trends to breaking news for Lineups.

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