San Francisco 49ers vs Los Angeles Rams Preview (10/30/22): Betting Odds, Prediction, Depth Charts

The 49ers head to Los Angeles for this NFC west rematch after beating the Rams 24-9 in week 4. The NFC’s final two teams in 2021 have both slumped to .500 or below this season, with the Rams starting 3-3 and the 49ers at 3-4. Will the 49ers win this series outright? Or will the Rams even it to position themselves for a run in the division? Let’s check out the odds, injuries, and matchups for this contest.

San Francisco 49ers Vs. Los Angeles Rams Betting Odds


The 49ers are (-1.5) road favorites versus their divisional rivals, the Rams (+1.5). The over/under is set at 42.5. The 49ers have won seven straight regular season games versus the Rams, and Vegas is giving them a slight edge to continue this streak.

San Francisco 49ers Vs. Los Angeles Rams Prediction

The 49ers come off rough back to back losses, including last week’s disastrous 44-23 loss to the Chiefs. Their defensive injuries showed when they gave up 523 total yards of offense to the Chiefs. This included allowing Patrick Mahomes to throw for 417 yards, when earlier this season they had the number one pass defense. Offensively, Jimmy Garoppolo continues to hold back one of the deepest skill position groups in the league. With TE George Kittle, WR Deebo Samuel, WR Brandon Aiyuk, RB Jeff Wilson and RB Christian McCaffrey all healthy and playing well, there’s no reason another team should outscore the 49ers by 21 points, yet the lack of a star QB continues to hold the 49ers back.

This season has gone anything but planned for the Rams. Their offense has failed to be the balanced unit we expect under Sean McVay, with the 2nd worst run game at 70.5 yards per game. Though they have the 11th best pass game in the league, this is lower than expected for a McVay and Stafford led team coming off a Super Bowl win. The good news for the Rams is despite their offensive woes, the defensive is still 5th overall in yards allowed. The defense gave up just 10 points to the Panthers in their game before the bye week, and safety Nick Scott made the following highlight interception.
https://twitter.com/RamsNFL/status/1581780769445269504?s=20&t=4gXZ6_OORDFyj_rs9L4ibA

I predict the 49ers will continue their streak of regular season wins against the Rams. The 49ers defensive line has a great matchup versus the poor Rams offensive line, while new RB Christian McCaffrey should spark the 49ers offense.

Prediction: 49ers win 27-20, over hits.

Betting Trends

  • 49ers are 4-0 ATS in their last 4 vs. NFC West
  • Rams are 4-9 ATS vs. a team with a losing record

Key Injuries

San Francisco 49ers Injuries: Dre Greenlaw (Q), Deebo Samuel (Q), Kyle Juszczyk (D), Arik Armstead (Q), Jordan Willis (Q), Jason Verrett (Q)

Los Angeles Rams Injuries: Van Jefferson (Q), Troy Hill (Q), Bobby Brown III (Q), Decobie Durant (Q), Cam Akers (Q), Brian Allen (Q), Daniel Hardy (Q), Quentin Lake (Q)

Key Matchups

49ers Run Game vs the Rams Defensive Front

The 49ers added a major piece to their run game by trading for Christian McCaffrey a week ago. Though they have often been known for their run game, the 49ers run game only ranks 15th going into week 8. The 49ers gave McCaffrey limited usage in his first game with the team, and he still went for a promising 38 yards on just 8 carries. With another week to adjust to the Shanahan offense, expect McCaffrey to take on a bigger role in the Niners backfield. The Rams have the 9th best rushing defense, but gave up 158 scrimmage yards to McCaffrey two weeks ago when he was with the Panthers. McCaffrey will have to look out for Jalen Ramsey, who put this ginormous hit on him just a couple Sundays ago.
https://twitter.com/RamsNFL/status/1581773331472125952?s=20&t=4gXZ6_OORDFyj_rs9L4ibA

Rams Offensive Line vs 49ers Defensive Line

In the week 4 matchup between these two teams, the 49ers ability to sack Stafford 7 times helped them seal a win. Stafford is tied for 3rd most sacked quarterback per game, getting taken down an average of 3.67 times a game. The good news for the Rams is center Brian Allen returned to practice from injury and will hopefully play Sunday. The Rams will need to put extra attention on stopping DE Nick Bosa. Bosa is tied for second in the league with 7 sacks and put up two sacks versus the Rams the last time these teams played.
https://twitter.com/49ers/status/1584317546651561984?s=20&t=4gXZ6_OORDFyj_rs9L4ibA

San Francisco 49ers Depth Chart

QB: Jimmy Garoppolo
RB1 Christian McCaffrey
RB2: Jeff Wilson Jr.
LWR: Deebo Samuel
RWR: Brandon Aiyuk
SWR: Jauan Jennings
TE1: George Kittle

Los Angeles Rams Depth Chart

QB: Matthew Stafford
RB1: Darrell Henderson Jr.
RB2: Cam Akers
LWR:Allen Robinson II
RWR: Van Jefferson
SWR: Cooper Kupp
TE1: Tyler Higbeetarget=”_blank”>Mike Gesicki

A UCLA graduate, Eva is an experienced football writer who specializes in NFL game analysis and weekly storylines. In her free time you can usually find her cheering on the 49ers or watching the latest Josh Allen highlight clip.

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