Seattle Seahawks vs. Arizona Cardinals Preview (11/6/22): Betting Odds, Prediction, Depth Charts

In the last week of the first half of the season, the Seattle Seahawks are on the road to take on the Arizona Cardinals in an NFC West showdown.

The Seahawks put the Giants away at home last week to hop to 5-3 on the year and secure their first place seat in the NFC West. A win here for the Hawks would put them on a four-game winning streak heading into their European matchup in Munich and would further establish their relevance in the division.

This game marks the first of three straight tough divisional matchups for Arizona as they take on the Rams and 49ers in subsequent weeks. They lost to the Vikings last week in DeAndre Hopkins’ second game back this season bringing them to 4-4 on the season and fourth place
in the NFC West. Read on for odds, predictions, depth charts, injuries, and more.

Seattle Seahawks vs. Arizona Cardinals Betting Odds


The Cardinals opened as 3.5-point home favorites in this division rivalry game. After an Arizona loss and a Seattle win in Week 8, the line saw some movement from 3.5 points to 2 points, but Arizona is still favored. They are -120 moneyline favorites and Seattle is +110 road underdogs.

Seattle has gone 5-3 ATS this year while Arizona has gone 4-4 and are trying to gain some momentum in a competitive NFC West division. The over/under is 49 points – one of the highest projected totals of all Week 9 games.

Seattle Seahawks Vs. Arizona Cardinals Analysis and Prediction

The Seahawks are on a three-game winning streak which coincidentally, started with their win over Arizona in Week 6. It was continued last week in their 27-13 win over the New York Giants.

Geno Smith and the offense ranks seventh in offense DVOA this week after a 212-yard, zero interception, two-touchdown game from Smith. As great as their offense has been, their defense has been even better despite the rocky start. They are allowing the fifth-fewest total yards per game over the last three games (289.7), and opponents have been 15-of-47 on third down and 2-of-9 on fourth downs in that same span.

The Hawks held Saquon Barkley to a season-low 53 yards rushing last week and the Chargers to a team total of 53 rushing yards the week prior. Compared to their first three games in which they allowed over 450 rushing yards and went 1-2, it’s clear that their defense is a big reason why Seattle is now 5-3.

Seattle played well against the Cardinals in Week 6 but didn’t have to face DeAndre Hopkins who is now back in the lineup. He has 262 total receiving yards in his two games back and makes this offense a lot more dangerous.

The Cardinals played very well in Week 8 despite the losing result. Kyler Murray threw a season-high three touchdowns and had 326 passing yards. He is certain to have his work cut out for him this week, even with Hopkins, as the Seattle defense has been firing on all cylinders as of late and provide very stiff competition.

These two teams have gone 1-1 against each other for three years straight now. Seeing that the Cardinals are 3-5 and at the bottom of the NFC West, they won’t roll over easily on this one, knowing that the postseason is as good as gone without a win here. While the Seahawks are the more fun team to root for here, I think the Cardinals will scrape out a win at home with DeAndre Hopkins. The game will be close and Seattle is the better team right now, but circumstances suggest Arizona takes this one.

My Prediction: Arizona wins 23-21, under 49 points

Betting Trends

  • Seahawks 2-2 ATS as away underdog
  • Seahawks have covered in four of their last five games
  • Over is 3-1 when Seahawks are away
  • Cardinals have covered three of their last five games
  • Cardinals 3-1 ATS after a loss
  • Cardinals 0-2 ATS in divisional games
  • Under is 2-0 in Cardinals divisional games

Key Injuries

Seattle Seahawks Injuries: Darrell Taylor (Q)

Arizona Cardinals Injuries: James Conner (Q), Marquise Brown (O)

Key Matchup

Tariq Woolen & Seattle Secondary vs. DeAndre Hopkins
Last time these two teams faced off, the Seattle defense absolutely decimated this Arizona offense. Not only did they not allow a touchdown, but they had six sacks, an interception, and forced two turnovers. This time, they’ll have veteran receiver DeAndre Hopkins to deal with, which makes this offense objectively more dangerous than the offense they played in Week 6.

Rookie Tariq Woolen, who is tied for first in interceptions this year, has been a huge bright spot on this defense – his size and speed is very evenly matched with that of Hopkins. This should be one of the more interesting matchups of the game especially given the rookie-veteran contrast.

Seattle Seahawks Depth Chart

QB: Geno Smith
RB1: Kenneth Walker
RB2: DeeJay Dallas
LWR: DK Metcalf
RWR: Dee Eskridge
SWR: Tyler Lockett
TE1: Will Dissly

Arizona Cardinals Depth Chart

QB: Kyler Murray
RB1: James Conner
RB2: Eno Benjamin
LWR: Marquise Brown
RWR: Rondale Moore
SWR: DeAndre Hopkins
TE1: Zach Ertz

Mia Fowler is a graduate of Chapman University where she studied business marketing and journalism and played on the women’s soccer team. Following her 16-year journey with soccer, she started writing for Lineups.com. She specifically enjoys analysis of the NFL.

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