Biggest NFL Week 13 Odds Movement From Look-Ahead Lines

The NFL delivered several upsets and close calls for heavy favorites on Sunday of Week 12. As is often the case when injuries and surprising results occur over the weekend, oddsmakers have made some significant changes to this week’s betting lines. 

Below, we break down line movements for NFL Week 13 games compared to the look-ahead lines prior to Week 12. We also touch on changes with the total and moneyline to help you look for value when considering Week 13 bets at your favorite sportsbook app. 

NFL Week 13 Line Movement 

San Francisco 49ers at Buffalo Bills: Buffalo Bills -6.5 (-112) on BetRivers

• This is the biggest shift of the NFL betting week, as the 49ers have moved from three-point road underdogs ahead of a Sunday Night Football matchup to +6.5 and climbing with the Bills coming off a bye week. Brock Purdy was scratched last Friday with a shoulder injury, and Trent Williams and Nick Bosa were unable to go for the Niners, leading to a 38-10 blowout loss at the Packers that moved the defending NFC champs to 5-6 and put a significant dent in their fading playoff hopes. The Bills are coming off a bye and could get key players back, including receiver Keon Coleman and linebacker Matt Milano. The Niners also lost linebacker Renardo Green (neck) last Sunday, adding to their injury woes.

Las Vegas Raiders at Kansas City Chiefs: Kansas City Chiefs -13.5 (-115) on DraftKings

• The Chiefs were already double-digit favorites for this matchup on Black Friday, with an 11-point spread, and now the number is up to 13.5 points at most books with the Raiders expected to start Desmond Ridder instead of Gardner Minshew, who is done for the season with a broken collarbone. The Raiders shocked the Chiefs on Christmas at home last year, so revenge could be a narrative for the two-time defending champs. Isiah Pacheco and defensive end Charles Omenihu could return for the Chiefs. 

Cleveland Browns at Denver Broncos: Denver Broncos -3.5 (-110)

• Last week, the Broncos shifted from three-point favorites to -5.5 and eventually moved up to -6.5 favorites ahead of their AFC West road game at the Raiders. After pulling out a close win (and close cover), the Broncos are moving in the other direction to start Week 13. Denver opened as a seven-point home favorite and is down to -5.5 ahead of a Monday Night Football home game against Cleveland, which beat the Steelers in a snowstorm last Thursday. Denver could be without starting cornerback Riley Moss (knee) in Week 13. The total is also on the move in this game, with some books showing 42 points after the look-ahead line was at around 40.5 points. 

New York Giants at Dallas Cowboys: Dallas Cowboys -6.5 (-110) on DraftKings

• While the Cowboys bounced back for their first win since losing Dak Prescott (hamstring) for the season, the Giants came out completely flat after benching, and eventually cutting, starting quarterback Daniel Jones. Dallas has thus moved from -2.5 through a key number to -3.5 or -4 favorites for this Thanksgiving game. The Cowboys haven’t won at home this season, with a few historically bad blowouts mixed into those results. With Tommy DeVito captaining a struggling Giants offense, the total has shifted from 39 points down to 37 at most books. The Giants lost tackle Jermaine Eluemunor (quad) and edge rusher Azeez Ojulari (toe) to injuries in Week 13. 

Tennessee Titans at Washington Commanders: Washington Commanders -5.5 (-115) on DraftKings

• The Titans pulled off an upset win at Houston as eight-point underdogs, and the Commanders failed to beat the Cowboys in a Week 12 home game as 10-point favorites. Those results and injuries to Austin Ekeler (concussion), Brian Robinson Jr. (ankle), and tackle Andrew Wylie (head) have led to a shorter line for the home team, moving the Commanders off the key number of 7 down to favorites of 5.5 points. 

Pittsburgh Steelers at Cincinnati Bengals: Cincinnati Bengals -3 (-110) on DraftKings

• Both of these AFC North teams are coming off extended rest, and the Bengals are the more desperate team, so they’ve shifted from -1.5 to -2.5 at home due to some early action. The Bengals can hope to get tackle Orlando Brown back for this matchup but lost cornerback DJ Turner (groin) in Week 11. Alex Highsmith has been playing through an ankle injury for Pittsburgh. 

Houston Texans at Jacksonville Jaguars: Houston Texans -3.5 (-110) on DraftKings

• The Texans stumbled in yet another close game and are now 3-6 against the spread as favorites this season. The Jaguars are coming off a bye week and could have Trevor Lawrence (shoulder) back under center. That has led the spread to shift from +6.5 to +5.5 for the home underdog Jags. 

Seattle Seahawks at New York Jets: Seattle Seahawks +1.5 (-110) on DraftKings

• We have total movement ahead of this non-conference clash at MetLife Stadium. The Seahawks defense has been lights out over the past few weeks, and the Jets have struggled offensively at times. So books have shifted this total (which opened at 46.5 earlier this season) from 44.5 points to 42.5. 

Tampa Bay Buccaneers at Carolina Panthers: Tampa Bay Buccaneers -7 (-105) on DraftKings

• This total has also dropped a couple of points from 46.5 on the look-ahead line to 44.5 points. The Panthers got healthier defensively during their Week 11 bye and gave Patrick Mahomes and the Chiefs some problems last week. Baker Mayfield suffered a neck stinger when the Bucs beat the Giants in Week 12, and they lost edge rusher Joe Tryon-Shoyinka (ankle) in the win.