College Football Week 4 Lines & Predictions

Week 4 has a few top-25 clashes, starting with an early game between Notre Dame and Wisconsin. Both have struggled out of the state, despite a couple of wins. Arkansas and Texas A&M clash in an SEC battle. The Hogs are at home this week, where they previously toppled Texas. Tennessee travels to Florida in a major SEC rivalry, while West Virginia will try and take down Oklahoma on their turf. For those staying up for some Pac-12 action, Arizona heads to Oregon and Colorado makes a trip to Tempe, to face the Arizona State Sun Devils. Get ahead on the Week 4 lines and a few picks from the Lineups staff.

College Football Week 4 Lines

Saturday, Sept. 25th

Notre Dame Fighting Irish (12) at Wisconsin Badgers (18)

Notre Dame has given all of us every single reason to fade them. Its first two games were against Florida State and Toledo, both of whom it beat by three points, thanks to last-second drives. The Fighting Irish just as easily could be 0-2 as 2-0. Additionally, the week after they squeaked by the Seminoles, Florida State lost against Jacksonville State at home. That’s right, Notre Dame beat a team by three points that lost to Jacksonville State.

Meanwhile, Wisconsin lost its home opener in the most “Big 10 football” fashion ever with a final score of 16-10. The Badgers dropped it to the Penn State Nittany Lions, an excellent football team this year. Last season was pathetic for Penn State, but it is incredibly determined now. Wisconsin followed up that loss with a brutal beatdown of Eastern Michigan 34-7.

I like this Wisconsin team, even though the Badgers can struggle offensively sometimes. I was born and raised a Notre Dame fan, but I cannot let personal biases get in the way of my job.

Best Bet: Wisconsin ML

Author: Drew Norton

Rutgers Scarlett Knights at Michigan Wolverines (25)

Very commendable not letting personal biases affect your job, Drew. I agree on the Wisconsin pick. However, I’m gonna go ahead and let my personal biases steer me in the direction of an excellent opportunity to make some money betting on my Michigan Wolverines. Michigan has boat raced two teams to start the season in Western Michigan and Washington with an average margin of victory of 27 points.

Does that mean we’re ready to take on Ohio State? Probably not. But it does give me great confidence in our ability to beat Rutgers in the Big House. A narrow triple-overtime 48-42 Michigan win in New Jersey last year was concerning, but Michigan now has a 6-game win streak against Rutgers with an average margin of victory of 37.5 points.

In that win streak was a 52-0 win in 2019 and a 78-0 win in 2016. Michigan has found an offensive identity centered around the lethal running back duo of Blake Corum and Hassan Haskins and, while it’s too early to know for sure, so far so good with new defensive coordinator Mike Macdonald. Rutgers had an over/under win total of four games heading into the season, and I’m very confident one of those wins will not come in the hostile confines of the Big House.

Best Bet: Michigan ML, Michigan To Cover

Author: Jacob Wayne

Texas A&M Aggies (7) at Arkansas Razorbacks (20)

How can you not be a little high on Arkansas after their Week 2 upset of the Texas Longhorns? The team held Texas to 256 total yards while amassing 333 rushing yards alone. In a game where they were 7-point underdogs, the Razorbacks showed poise and beat down their ranked opponent. Texas A&M, on the other hand, played it a little too close to the chest recently against the Colorado Buffaloes.

The Aggies were 17-point favorites against the Buffs, but barely escaped the game in a 10-7 win. They also allowed 171 rushing yards in the matchup, which has got to excite the talented Arkansas running game. Grab the points with Arkansas and don’t be too shocked to see another big upset.

Best Bet: Arkansas +7.5

Author: Anthony Elio

Sam Shefrin is the founder of, Inc. Before Lineups, he started Daily Fantasy Cafe, Inc. in 2014. Armed with a passion for sports and every Atlanta team, his journey continues with the goal of making Lineups a premier sports analytics destination. He has been quoted on for industry insight and his websites featured on NBATV, Yahoo! Sports, Fantasy Pros, Bleacher Report and SB Nation.

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