College Football Week 6 Lines & Predictions

Compare odds and lines across all of the Week 6 College Football games. Our Lineups Staff has written a handful of picks and predictions for this week, which features plenty of big games. Auburn will host Georgia in a massive SEC game, while Arkansas will take on Ole Miss. We also have the Red River Showdown between Texas and Oklahoma. Keep up to date with all the Week 6 College football odds.

College Football Week 6 Lines

Temple Owls At Cincinnati Bearcats

I almost don’t care what the spread is for this game or how wide it becomes. The Cincinnati Bearcats are leaps and bounds better than the Temple Owls through the first four weeks. To give you an idea, Temple lost to Rutgers by a score of 61-14. Rutgers ranks a respectable 49th in the nation in points per game with 30.3. An important thing to remember, though, is that it includes the 61 point massacre of Temple. Without that game, Rutgers would rank much lower. The Bearcats have a much different story; they rank fifth in the nation with 43.5 points per game and hold teams to 19 points per game, which is good for 25th in the country. Meanwhile, Temple’s defense does not rank as poorly as it might otherwise have had the Owls not played Akron and Wagner already, who boast a combined record of 1-5. In short, this game should be over in the first half, and the spread should not be an issue at all for the Bearcats. Through Week 4, Temple was 1-3 against the spread, while Cincinnati was 2-1 ATS. I would take the Cincinnati Bearcats against the spread around 30 or better; this should be a brutal beatdown of monumental magnitude.

Best Bet: Cincinnati ATS

Author: Andrew Norton

No. 6 Oklahoma Sooners At Texas Longhorns

While Oklahoma is one of the top-rated teams in the country, they have struggled to cover the spread against lower-rated teams. With just a five-point win over Tulane, seven-point win over Nebraska, and three-point win over West Virginia, the Sooners have repeatedly let worse teams who should not be competitive hang around. Spencer Rattler is having a strong season, but the Sooners offense has struggled to finish drives and that has resulted in lower-scoring games for what should be one of the highest-scoring teams in the country. In his first year as head coach, Steve Sarkisian has led to mixed results for Texas. However, they do have blowout wins over semi-respectable programs in Texas Tech and Louisiana. In Austin, Oklahoma will likely be favored by a boatload of points, but I’m banking on Texas making things uncomfortable for a team that has struggled to pull away in games this year.

Best Bet: Texas ATS

Author: Jacob Wayne

No. 25. Clemson Tigers at Syracuse Orange

After a dominant season that ended in a Sugar Bowl loss to the Ohio State Buckeyes, the Clemson Tigers have struggled to bring back that same dominance. In a Covid-filled 2020 season, Clemson went 9-1 but has struggled so far this year with a record of 2-2. The Tigers struggled to score in Week 1 against the Georgia Bulldogs in a 10-3 loss. They followed up that loss with a dominant 49-3 win against the FCS South Carolina State Bulldogs. They then squeaked out a 14-8 win against the Georgia Tech Bulldogs followed by a heartbreaking 27-21 overtime loss against the NC State Wolfpack. Tigers quarterback DJ Uiagalelei has struggled this year, only throwing three touchdowns in four weeks. He has not thrown for more than 200 yards in a game and has also thrown three interceptions. Tigers running back Will Shipley has been pretty effective, but he got injured in Week 4 and will miss the next three-four weeks. That leaves the Tigers pretty shorthanded. Running back Lyn-J Dixon, who is averaging 2.2 yards per carry, will step up as RB1. On the other side, the Syracuse Orange has looked mediocre. They are 3-1 but have had an easy schedule of Ohio University, Rutgers, the University of Albany, and Liberty University. With that being said, I do expect Syracuse to cause enough problems for the Tigers. I do not expect the Clemson Tigers to score enough points to cover the spread.

Best Bet: Clemson ATS

Author: Max Heering

Penn State Nittany Lions at Iowa Hawkeyes

I’ve liked both of these teams a lot throughout this season. The Penn State Nittany Lions have beaten the teams they were supposed to beat while having major statement wins against the Wisconsin Badgers and Auburn Tigers. Meanwhile, the Iowa Hawkeyes have been winning games with a strong defense and running game, as we saw in their big upset over Iowa State. Penn State QB Sean Clifford has been putting up great numbers for the Nittany Lions, and has been spreading it out to a talented wide receiver group. Meanwhile, Iowa running back Tyler Goodson has been shredding up defenses, as seen with his monster 153-yard performance against Kent State, complete with three TDs. While it’s not an easy decision, I simply like Iowa’s defense more than Penn State’s offense, and that’s going to make all the difference. The Hawkeyes defensive line has already accounted for double-digit sacks, and defensive backs Riley Moss and Matt Hankins are getting turnovers. They could wreak some havoc against the Nittany Lions here. And, while he hasn’t put up the biggest stats in college football, Iowa QB Spencer Petras does enough to win when needed, as we saw with the comeback win over the Colorado State Rams in Week 4. I could also see home field advantage playing a part in this game, as Iowa seems to perform at a higher level in Kinnick Stadium. The preseason line for this game sat at Iowa +3, but I think a little sprinkle on the moneyline is worth a look here.

Best Bet: Iowa Hawkeyes Moneyline

Author: Anthony Elio

Sam Shefrin is the founder of, Inc. Before Lineups, he started Daily Fantasy Cafe, Inc. in 2014. Armed with a passion for sports and every Atlanta team, his journey continues with the goal of making Lineups a premier sports analytics destination. He has been quoted on for industry insight and his websites featured on NBATV, Yahoo! Sports, Fantasy Pros, Bleacher Report and SB Nation.

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