NFL Week 5 Odds and Lookahead Lines: Four Bets to Make This Weekend

Get a jump on NFL Week 5 odds & lookahead lines, along with four bets to place before lines begin to move for next week. Find updated NFL Week 5 odds below.

Week 5 NFL Odds & Lines

Lookahead NFL odds & Lines for Week 5

NFL Week 5 Betting Picks

The Cowboys and Ravens suffered major upsets in Week 3. If Week 4 brings more surprises, we could see a few Week 5 lines shift as the games approach.

Let’s take a look at the early Week 5 odds and which bets to place early.

Buffalo Bills (-4.5) vs. Jacksonville Jaguars

The Jaguars just haven’t looked convincing this season. They got the job done in Week 1, but the offense has let Trevor Lawrence down ever since. While Jacksonville’s defense deserves credit for keeping it close against the Chiefs in Week 2, the defense had nothing on C.J. Stroud and the Texans last week. A matchup with a gritty Falcons team in London could be trouble if both sides of the ball don’t take a step forward.

The biggest reason this line can move, though, is the Bills. Buffalo has a huge opportunity to knock off a respected Dolphins team, and after outsourcing opponents 75-6 since going down early against the Raiders, both sides of the ball seem to have recovered from the Week 1 loss in East Rutherford.

With this game in Buffalo, it wouldn’t be stunning to see the line move a point or two in the Bills’ direction.

Indianapolis Colts Moneyline (-118) vs. Tennessee Titans

The Titans were walloped by the Browns in Week 3, despite Cleveland’s running game having no momentum. Tennessee’s pass defense is an issue, and the offense is an even larger issue. With the Bengals in town for Week 4, it’s very unlikely the Titans will be able to regain momentum by the time their matchup with the Colts approaches.

The Colts host the Rams in Week 4 and have Anthony Richardson back. That’s a winnable game, and it’s one big opportunity for Richardson to earn the respect of oddsmakers. It’s hard to see the Titans being favored under any circumstances in Indianapolis – not with how hard the Colts have been playing on both sides of the ball. If their offense is mauled by the Bengals’ swarming defense, this line is only going to shift in the Colts’ direction.

Cincinnati Bengals (-7) vs. Arizona Cardinals

I was encouraged by what the Bengals did in Week 3, even after the offense got off to a slow start. Joe Burrow re-established his connection with Ja’Marr Chase in the second half, which transformed the offense, and the defense was downright dominant.

Cincinnati has a favorable matchup against the Titans in Week 4. Tennessee’s only real strength right now is its run defense. The rest is a major work in progress, and the Benga’s defense could have a field day.

The Cardinals are set to come crashing back to Earth against a well-rested 49ers team. With this line hovering right near a touchdown, it wouldn’t be surprising at all to see the Bengals favored by 8 or 9 points by next week if they show oddsmakers they’re steadily rounding into form.

Pittsburgh Steelers Moneyline (+108) vs. Baltimore Ravens

The Steelers don’t look convincing, but when do they ever look convincing? The offense will look like a mess, and they will still win more games than not because of a ferocious pass-rush. Week 4 might not be much different, with T.J. Watt and Alex Highsmith targeting a depleted Texans offensive line.

The Ravens have more talent than the Steelers, but injuries have really affected their depth on both sides of the ball. With this Week 5 matchup in Pittsburgh and the Steelers’ pretty solid recent history against the Ravens in mind, this could be another grind-it-out game that the Steelers win just based on their own depth and health.

It wouldn’t be surprising to see this line tighten as the game approaches, with Baltimore currently favored by 2 to 2.5 points.

Dan is a lifelong sports fan and graduate of Boston University. He’s covered several sports on Instagram since he was 12 and now writes about everything from betting trends to breaking news for Lineups.

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