NFL Week 6 Underdog Betting Picks, Odds, and Bets: Can Jets Pull Of Upset?

The Giants got Sunday’s Week 5 action started with a surprise win over the Packers in London, pulling off one of the season’s largest upsets. Which underdogs could be worth betting in Week 6?

NFL Week 6 Underdog Betting Picks

Atlanta Falcons (+5.5) vs. San Francisco 49ers

The 49ers have clearly started to find a rhythm after a tumultuous first three weeks, but the injury bug is threatening to derail their momentum. San Francisco could be without nearly its entire defensive line in Atlanta, as Nick Bosa is highly questionable while Javon Kinlaw and Arik Armstead are set to miss Sunday’s game. The 49ers also lost cornerback Emmanuel Moseley and safety Jimmie Ward in Week 5.

A Falcons offense that has had its ups and downs but has generally outplayed its talent level should benefit. If Kyle Pitts is back, which is the expectation, Atlanta might be able to throw the ball more effectively than usual. A bend-don’t-break defense that we’ve seen from the Falcons will also probably fare better than Carolina did against Jimmy Garoppolo and the 49ers. I see at least a close game in Atlanta this weekend.

Dallas Cowboys (+6) vs. Philadelphia Eagles

Aside from their win against the Giants, the Cowboys have done nothing but prove me wrong since Dak Prescott went down. It’s time we start believing in Dan Quinn’s defense, which made the offense of the reigning champs look like the Carolina Panthers in Week 5. A Cowboys win is far from guaranteed, but the defense has single-handedly won games for this team and has to be feared even in Philadelphia.

The Eagles have plenty to be excited about on the offensive side of the ball, though the win over the Cardinals wasn’t their best work. Dallas’ defense won’t let the Eagles get away with that. Trevon Diggs may have some lowlights against this talented group of Eagles receivers – Cooper Kupp made some plays against him while the rest of the offense struggled on Sunday – but the ferocious pass-rush of the Cowboys could keep this game low-scoring.

On the road, Cowboys +6 is the safer play than Cowboys moneyline.

New York Jets (+7) vs. Green Bay Packers

After five games, Packers fans still haven’t been able to R-E-L-A-X. Green Bay’s prolonged offensive struggles are starting to become a concern, and the Patriots’ blueprint for a near-win in Green Bay with an undermanned team could be one the Jets follow.

After back-to-back wins, New York faces a quarterback pretty far ahead of Mitchell Trubisky and Skyler Thompson, and oddsmakers have responded. The Packers are still favored by a touchdown. If Breece Hall continues to run wild and Zach Wilson turns his best moments from the last two games into one consistent performance, the Jets can hang with the Packers just as the Giants did.

The cornerback duo of Sauce Gardner and D.J. Reed has been excellent so far this season. It’s not far-fetched to believe they can shut down a shaky group of Packers and receivers and make this a close, low-scoring game down the stretch.

Seattle Seahawks Moneyline (+122) vs. Arizona Cardinals

The Seahawks (yes, the Seahawks) are top-10 in both total yards and points through five weeks. Geno Smith has a terrific connection with both Tyler Lockett and D.K. Metcalf, winning games over the Broncos and Lions while staying competitive in others. A below-average Cardinals defense may have a hard time with this group in an always tough Seattle environment.

Arizona’s offense is going up against a similarly uninspiring Seahawls defense, but the Cardinals haven’t shown much themselves in recent weeks. With an inefficient running game and Kyler Murray still unable to put together two solid halves of football, Seahawks +122 might be the better value here. If the Cardinals drop this one and fall to 2-4, it’s officially time to panic.

Dan is a lifelong sports fan and graduate of Boston University. He’s covered several sports on Instagram since he was 12 and now writes about everything from betting trends to breaking news for Lineups.

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