San Francisco 49ers vs. Tennessee Titans Player Props (12/23/21)

This week, we are getting another excellent matchup on Thursday Night Football with a playoff contender from each conference meeting with high stakes on the line. The Titans are still reeling and trying to find a way to generate offense without Derrick Henry and A.J. Brown, while the 49ers are rolling offensively right now with George Kittle and Deebo Samuel fully healthy. San Francisco is favored in this match, but there should be good player prop value on both sides of the field. You can use the player prop search tool below to find the best odds in your market for the 49ers vs. Titans game.

San Francisco 49ers Vs. Tennessee Titans Player Prop Search Tool

Ryan Tannehill Under 210.5 Passing Yards

Tannehill has had a rough go of it lately, with an average of just 145.6 passing yards per game over his last three outings. There seems to be a chance A.J. Brown plays on Thursday night, which would be a massive boon for Tennessee. I would be surprised if he does play on a short week as he has yet to practice as of Tuesday afternoon, but even if he does, I don’t expect a massive performance from Tannehill. The 49ers have allowed just 213.2 passing yards per game this season, the seventh-fewest in the NFL, and Tannehill has struggled to find chemistry with any of the Titans’ receivers with Brown, Julio Jones, and Marcus Johnson all injured. If Brown does play, that would be enough for me to stay away from this prop, but there’s a good chance he would still be held to under 210 passing yards given the matchup.

Deebo Samuel Over 4.5 Rushing Attempts

Elijah Mitchell has been ruled out of this game, which means we should see a steady dose of Deebo Samuel in the 49ers’ rushing offense. Samuel has averaged 6.6 rushing attempts per game over his last five outings and has surpassed this line in all five. While Tennessee does have a stout run defense – they have allowed just 86.9 rushing yards per game, second-fewest in the NFL – San Francisco doesn’t use Samuel like a traditional wide receiver or running back. I’m expecting Kyle Shanahan to engineer touches for Samuel in creative ways like he has all season, and with Mitchell out, that means more rushing work. You can also bet on Samuel to score a touchdown, which is still somehow close to even odds even though he has scored in five straight games.

D’Onta Foreman Over 13.5 Rushing Attempts

Foreman has emerged as the Titans’ lead running back with Derrick Henry on Injured Reserve, and he should fill that role again this week. Foreman has averaged 18 rushing attempts per game over his last three games. That number would be even higher if the Titans didn’t blow out the Jaguars; he only saw 13 carries in that game as Tennessee let other running backs get touches in the second half. The 49ers have allowed just 108.6 rushing yards per game, 13th-fewest in the NFL, and rank second in rush defense DVOA, so I wouldn’t be thrilled about playing the yardage for Foreman. However, I’m confident he’s going to get the rushing work so long as the Titans don’t get blown out in this game, something I’m not currently projecting.

Nick Bosa Over 2.5 Tackles/Assists

This game presents a rare opportunity where I’m recommending a defensive player prop, and you can feel confident betting on one of the best edge talents in the league in Nick Bosa. In 11 of his last 14 games, Bosa has surpassed this stat, and the Titans have allowed a defensive end to hit 3+ tackles/assists in 12 of their previous 14 games. Tennessee’s David Quessenberry has emerged as a consistent starting right tackle across from Taylor Lewan, but Bosa has preyed on better offensive tackles than Quessenberry all season. With the Titans likely looking to establish the run with Ryan Tannehill struggling to pass against the San Francisco secondary, I expect Bosa to be in on some big tackles for loss in this game.