NFL Week 16 Fantasy Football Rankings: Who Can You Trust on Semi-Finals Week?

If you’re still competing in your fantasy football playoffs, congratulations on being one week closer to winning a championship. With COVID-19 cases on the rise and injuries still playing a significant factor, lineup decisions are as difficult as ever. Luckily, I have you covered with updated rankings to help with your start/sit decisions. As always, you can hit me up on Twitter if you need further clarification on any dilemmas you are having. In this article, I’ll give my brief thoughts on some of the players who are garnering the most discussion for Week 16.

NFL Week 16 Quarterback Rankings

    • Kyler Murray:

If you survived the first round of your fantasy football playoffs with Murray’s paltry 12.6 fantasy points against the Lions, you’ll be wondering if you can trust him in the next round. The Colts are middle of the pack against fantasy QBs, so Murray should bounce back with a solid game, but I wouldn’t expect a game-breaking performance from him without DeAndre Hopkins in the lineup.

    • Russell Wilson:

The Seahawks had a brutal offensive outing against the Rams last week, but I think you could do a lot worse than Wilson in your lineup this week. The Bears have allowed the sixth-most fantasy points to quarterbacks, making this a matchup Wilson can exploit, particularly with Tyler Lockett and DK Metcalf back in the lineup.

    • Joe Burrow:

After a tough game last week against the Ravens where he scored just 12.7 fantasy points, I’m expecting a big bounce-back performance from Burrow. The last time he faced the Ravens, he scored 26.6 fantasy points, and their secondary has only gotten more injured. I expect a big game from Burrow this week.

NFL Week 16 Running Back Rankings

    • Ronald Jones:

With Leonard Fournette likely out for the remainder of the regular season, Jones will be thrust into a huge role to close the year. If you have him stashed on your bench, consider yourself lucky, because you now have one of the few running backs who will see a full starting workload this week. The Panthers have a tough run defense, but I’m still starting Jones with confidence.

    • Rashaad Penny:

There will be plenty of questions about the Seattle running back after his poor performance against the Rams this week. Still, I expect a much better performance against Chicago, who allows the eleventh-most fantasy points to RBs this season. Penny should be treated as a low-end RB2, but one you are likely starting given the state of the running back position.

    • Miles Sanders:

The Eagles’ running back has suddenly gone over 100 yards in two straight games, the first such two-game streak of his career. With 42 carries over his last two games, Philly has made him the bellcow back ahead of a matchup against a vulnerable Giants’ front seven. If you’re still alive in your playoffs with Sanders on your roster, make sure to fire him up this week.

    • Sony Michel and Darrell Henderson:

There are a lot of questions out there about what to do with the Rams’ running backs, and it’s tough sledding as both players are expected to be involved this week. Sony Michel played on 73% of snaps last week, but Darrell Henderson should be healthier as he’s removed from his injury another week. The matchup against the Vikings is a good one, but it’s looking like these two backs will cannibalize each others’ fantasy value.

NFL Week 16 Wide Receiver Rankings

    • DeVante Parker:

The Dolphins’ wideout has suddenly emerged as a consistent fantasy option as Parker has 14 PPR points per game over the past two weeks. Jaylen Waddle is expected to return this week, reducing some of Parker’s upside, but the Saints have been an excellent matchup for wide receivers aside from what we saw last week. This year, New Orleans has allowed the third-most fantasy points to wide receivers, and I believe you can start both Waddle and Parker this week.

    • Russell Gage:

The emergence of Russell Gage has come from out of nowhere, and he has double-digit PPR points in five straight games. Over that span, he has been the WR11 in PPR scoring. I wouldn’t necessarily expect that production level to continue, but the Lions present a beatable matchup for him, and you can continue starting Gage with confidence as a solid WR2.

    • Christian Kirk:

With DeAndre Hopkins out last week, Kirk was one of the only players in the Arizona offense functioning at a high level as he caught nine passes for 94 yards and a score. His 12 targets led the team, and it’s clear that he’s their WR1 until Hopkins returns. The Colts have a stout defense that has gotten healthier lately, but Kirk should be started in all formats.

    • Gabriel Davis:

The Bills’ wideout has been a WR1 over the past four weeks of the season, but I’m tempering my expectations for him this week. New England allows the second-fewest fantasy points to wide receivers, and while weather won’t affect this game nearly as much as the teams’ first meeting, I don’t expect a prolific passing day from Josh Allen.

NFL Week 16 Tight End Rankings

    • Mike Gesicki:

After a bit of a letdown last week against the Jets, fantasy managers will be wondering if they can start Gesicki against the Saints, a solid tight-end defense. Jaylen Waddle’s return will take some target share from the tight end, as will DeVante Parker’s continued strong play, but Gesicki is still a low-end TE1 given the state of the position.

    • Hunter Henry:

The Bills have allowed the fifth-fewest fantasy points to tight ends this season, so it’s not an ideal matchup for Henry to exploit. Henry found the end zone twice last week, but he had combined for just four catches over his prior three games, including no catches against the Bills in their first meeting. It’s hard to predict what the Patriots offense will look like, and the range of outcomes for Henry is vast.

    • Jared Cook:

Cook has stuck around as a decent fantasy option at a tight end position where decent options are hard to come by. The Chargers could be without Austin Ekeler and Jaylen Guyton, both on the COVID-19 list, and Donald Parham after his scary concussion last week. If those absences hold, Cook would be an interesting upside play at TE.

I've been writing about sports for Lineups since the beginning of 2020 and on my own website since 2018. In May 2021, I graduated from the University of Michigan with a degree in sport management. I've been playing fantasy football for as long as I can remember and am now in far more leagues than any person should take part in. There are few things that give me as much joy and excitement as fantasy football, and I'm excited to share my input with you in your journey towards a championship.

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