NFL Odds Week 10

The current Week 10 betting odds for the 2022 NFL season feature everything from short home underdogs to heavy road favorites. Whether it be Chargers vs 49ers, Cowboys vs Packers or another one of the marquee matchups on this slate — Week 10 has a little something for everyone. Above all, though, Week 10 offers an opportunity for prospective bettors across the country to have a personal stake in the odds of the long-anticipated NFL season. At Lineups, we’ve dedicated our direct access to sportsbooks, data science avenues, and dedicated analysts to provide you with the most up-to-date information and analysis on week-by-week NFL odds. In the tables below, you’ll find odds comparisons from different sportsbooks as well as the best NFL odds on whichever side you believe has the edge.

DraftKings
FanDuel
BetMGM
Caesars
Game
DraftKings Odds
FanDuel Odds
BetMGM Odds
Caesars Odds
Date/Time Teams ML Spread O/U ML Spread O/U ML Spread O/U ML Spread O/U
11/10, 1:15 am GMT Carolina Panthers Panthers
+105
+2 -110
- -
-
+2.5 -110
- -
Chicago Bears Bears
-125
-2 -110
- -
-
-2.5 -110
- -
11/12, 2:30 pm GMT Indianapolis Colts Colts
+160
+4 -110
- -
+176
+5 -110
o41.5 -110
-
+3.5 -110
o41.5 -110
New England Patriots Patriots
-192
-4 -110
- -
-210
-5 -110
u41.5 -110
-
-3.5 -110
u41.5 -110
11/12, 6:00 pm GMT Cleveland Browns Browns
+130
+3 -110
- -
-
+3.5 -110
- -
Baltimore Ravens Ravens
-155
-3 -110
- -
-
-3.5 -110
- -
11/12, 6:00 pm GMT Houston Texans Texans
+340
+9.5 -110
- -
-
+10 -110
- -
Cincinnati Bengals Bengals
-440
-9.5 -110
- -
-
-10 -110
- -
11/12, 6:00 pm GMT San Francisco 49ers 49ers
-115
-1 -110
- -
-
-1 -110
- -
Jacksonville Jaguars Jaguars
-105
+1 -110
- -
-
+1 -110
- -
11/12, 6:00 pm GMT New Orleans Saints Saints
+110
+2.5 -110
- -
-
+3 -110
- -
Minnesota Vikings Vikings
-130
-2.5 -110
- -
-
-3 -110
- -
11/12, 6:00 pm GMT Green Bay Packers Packers
+130
+3 -110
- -
-
+3 -105
- -
Pittsburgh Steelers Steelers
-155
-3 -110
- -
-
-3 -115
- -
11/12, 6:00 pm GMT Tennessee Titans Titans
-115
-1 -110
- -
-
PK -110
- -
Tampa Bay Buccaneers Buccaneers
-105
+1 -110
- -
-
PK -110
- -
11/12, 9:05 pm GMT Atlanta Falcons Falcons
-142
-2.5 -120
- -
-
-2.5 -110
- -
Arizona Cardinals Cardinals
+120
+2.5 +100
- -
-
+2.5 -110
- -
11/12, 9:05 pm GMT Detroit Lions Lions
+136
+3 -110
- -
-
+3 -110
- -
Los Angeles Chargers Chargers
-162
-3 -110
- -
-
-3 -110
- -
11/12, 9:25 pm GMT New York Giants Giants
+185
+5.5 -110
- -
-
+5.5 -110
- -
Dallas Cowboys Cowboys
-225
-5.5 -110
- -
-
-5.5 -110
- -
11/12, 9:25 pm GMT Washington Commanders Commanders
+160
+4 -110
- -
-
+4 -110
- -
Seattle Seahawks Seahawks
-192
-4 -110
- -
-
-4 -110
- -
11/13, 1:20 am GMT New York Jets Jets
-135
-2.5 -110
- -
-
-2 -110
- -
Las Vegas Raiders Raiders
+114
+2.5 -110
- -
-
+2 -110
- -
11/14, 1:15 am GMT Denver Broncos Broncos
+205
+6 -110
- -
-
+6 -110
- -
Buffalo Bills Bills
-250
-6 -110
- -
-
-6 -110
- -