NFL Odds Week 10

The current Week 10 betting odds for the 2022 NFL season feature everything from short home underdogs to heavy road favorites. Whether it be Chargers vs 49ers, Cowboys vs Packers or another one of the marquee matchups on this slate — Week 10 has a little something for everyone. Above all, though, Week 10 offers an opportunity for prospective bettors across the country to have a personal stake in the odds of the long-anticipated NFL season. At Lineups, we’ve dedicated our direct access to sportsbooks, data science avenues, and dedicated analysts to provide you with the most up-to-date information and analysis on week-by-week NFL odds. In the tables below, you’ll find odds comparisons from different sportsbooks as well as the best NFL odds on whichever side you believe has the edge.

DraftKings
FanDuel
BetMGM
Caesars
Game
DraftKings Odds
FanDuel Odds
BetMGM Odds
Caesars Odds
Date/Time Teams ML Spread O/U ML Spread O/U ML Spread O/U ML Spread O/U
11/11, 1:15 am GMT Atlanta Falcons Falcons
-144
-2.5 -115
o41.5 -108
-150
-2.5 -115
o41.5 -110
Carolina Panthers Panthers
+122
+2.5 -105
u41.5 -112
+125
+2.5 -105
u41.5 -110
11/13, 2:30 pm GMT Seattle Seahawks Seahawks
+120
+2.5 -105
o45 -110
Tampa Bay Buccaneers Buccaneers
-145
-2.5 -115
u45 -110
11/13, 6:00 pm GMT Minnesota Vikings Vikings
+225
+6.5 -110
o46.5 -114
+220
+6.5 -110
o46.5 -110
Buffalo Bills Bills
-275
-6.5 -110
u46.5 -106
-275
-6.5 -110
u46.5 -110
11/13, 6:00 pm GMT Detroit Lions Lions
+134
+3 -112
o48.5 -110
+135
+3 -110
o48.5 -110
Chicago Bears Bears
-158
-3 -108
u48.5 -110
-160
-3 -110
u48.5 -110
11/13, 6:00 pm GMT Jacksonville Jaguars Jaguars
+380
+9.5 -108
o51.5 -110
+333
+9.5 -110
o51.5 -110
Kansas City Chiefs Chiefs
-490
-9.5 -112
u51.5 -110
-450
-9.5 -110
u51.5 -110
11/13, 6:00 pm GMT Cleveland Browns Browns
+152
+3 +100
o49.5 -105
+150
+3.5 -115
o49.5 -110
Miami Dolphins Dolphins
-180
-3 -122
u49.5 -115
-185
-3.5 -105
u49.5 -110
11/13, 6:00 pm GMT Houston Texans Texans
+198
+5.5 -115
o41.5 -105
+185
+4.5 -110
o41.5 -110
New York Giants Giants
-240
-5.5 -105
u41.5 -115
-225
-4.5 -110
u41.5 -110
11/13, 6:00 pm GMT New Orleans Saints Saints
+100
+1 -110
o39.5 -114
-105
+1 -110
o39.5 -110
Pittsburgh Steelers Steelers
-118
-1 -110
u39.5 -106
-115
-1 -110
u39.5 -110
11/13, 6:00 pm GMT Denver Broncos Broncos
+118
+2.5 -112
o39.5 -114
+115
+2.5 -110
o39.5 -110
Tennessee Titans Titans
-138
-2.5 -108
u39.5 -106
-135
-2.5 -110
u39.5 -110
11/13, 9:05 pm GMT Indianapolis Colts Colts
+166
+4 -115
o41.5 -110
+170
+4 -110
o41.5 -110
Las Vegas Raiders Raiders
-198
-4 -105
u41.5 -110
-210
-4 -110
u41.5 -110
11/13, 9:25 pm GMT Dallas Cowboys Cowboys
-200
-3.5 -110
o44.5 -110
-205
-3.5 -115
o44.5 -110
-210
-3.5 -110
o44 -115
Green Bay Packers Packers
+170
+3.5 -110
u44.5 -110
+172
+3.5 -105
u44.5 -110
+170
+3.5 -110
u44 -105
11/13, 9:25 pm GMT Arizona Cardinals Cardinals
+150
+3.5 -115
o37.5 -110
+150
+3.5 -110
o38 -110
Los Angeles Rams Rams
-178
-3.5 -105
u37.5 -110
-185
-3.5 -110
u38 -110
11/14, 1:20 am GMT Los Angeles Chargers Chargers
+300
+8.5 -115
o45.5 -112
+275
+8 -115
o45.5 -110
San Francisco 49ers 49ers
-375
-8.5 -105
u45.5 -108
-350
-8 -105
u45.5 -110
11/15, 1:15 am GMT Washington Commanders Commanders
+400
+11 -110
o43 -110
+390
+11.5 -120
o42.5 -115
+400
+11 -110
o43 -110
+400
+11 -110
o43 -110
Philadelphia Eagles Eagles
-500
-11 -110
u43 -110
-510
-11.5 -102
u42.5 -105
-550
-11 -110
u43 -110
-550
-11 -110
u43 -110