The current Week 16 betting odds for the 2022 NFL season feature everything from short home underdogs to heavy road favorites. Whether it be Eagles vs Cowboys, Packers vs Dolphins or another one of the marquee matchups on this slate — Week 16 has a little something for everyone. Above all, though, Week 16 offers an opportunity for prospective bettors across the country to have a personal stake in the odds of the long-anticipated NFL season. At Lineups, we’ve dedicated our direct access to sportsbooks, data science avenues, and dedicated analysts to provide you with the most up-to-date information and analysis on week-by-week NFL odds. In the tables below, you’ll find odds comparisons from different sportsbooks as well as the best NFL odds on whichever side you believe has the edge.