Sweet 16 March Madness Odds 2026
The Sweet 16 is where March Madness legacies are made, but teams still have to survive the opening weekend to get there. While the national title favorites typically project as strong contenders to reach the regional semifinals, the path is never easy. Upsets, tough matchups, and momentum swings during the first two rounds can quickly reshape the bracket and the betting board.
Several top seeds are expected to be popular picks to advance to the Sweet 16, thanks to their depth, star power, and favorable draws. At the same time, experienced mid-major programs and dangerous lower seeds often enter the tournament as trendy breakout candidates capable of crashing the regional semifinals.
As Selection Sunday approaches, sportsbooks are already offering odds on teams to reach the Sweet 16, giving bettors an early look at which programs are viewed as the strongest bets to survive the first weekend.
Here you can find the latest odds from the top March Madness betting sites for teams to make the Sweet 16, along with updated March Madness futures and bracket insights.
2026 March Madness Sweet 16 Odds
Thursday, Mar. 26
- No. 11 Texas vs. No. 2 Purdue , – 7:10 p.m./CBS
- No. 9 Iowa vs. No. 4 Nebraska , – 7:30 p.m./TBS
- No. 4 Arkansas vs. No. 1 Arizona , – 9:45 p.m./CBS
- No. 3 Illinois vs. No. 2 Houston , – 10:05 p.m./TBS
Friday, Mar. 27
- No. 5 Saint John’s vs. No. 1 Duke , – 7:10 p.m./CBS
- No. 4 Alabama vs. No. 1 Michigan , – 7:35 p.m./TBS
- No. 3 Michigan State vs. No. 2 UConn , – 9:45 p.m./CBS
- No. 6 Tennessee vs. No. 2 Iowa State , – 10:10 p.m./TBS
Sweet 16 Betting Information & Resources
- Dates: Mar. 26 – Mar. 27
- Location: Houston, TX (South) – San Jose, CA (West) – Chicago, IL (Midwest) – and Washington, D.C. (East).
- Elite 8 Odds
- Final 4 Odds
- March Madness Futures Odds
