Thursday Night Football Odds
Below, you will find everything you need regarding the Thursday Night Football schedule, game lines and much more!
Week 1 Thursday Night Football Game: San Francisco 49ers vs. Los Angeles Rams
The first Thursday Night Football game of the 2026 NFL season will feature NFC West rivals the San Francisco 49ers versus the Los Angeles Rams. What makes this TNF game so unique is that it will take place from Melbourne, Australia as part of the NFL’s International Series.
Week 1 Thursday Night Football – San Francisco 49ers vs. Los Angeles Rams Game Lines, Odds
Week 1 Thursday Night Football – San Francisco 49ers vs. Los Angeles Rams Odds Comparison
Week 1 Thursday Night Football – San Francisco 49ers vs. Los Angeles Rams DFS Picks
- Puka Nacua, WR (LAR)
- Matthew Stafford, QB (LAR)
- Christian McCaffrey, RB (SF)
- Mike Evans, WR (SF)
- Kyren Williams, RB (LAR)
Week 1 Thursday Night Football – San Francisco 49ers vs. Los Angeles Rams Key Players
San Francisco 49ers
- Brock Purdy, QB – Last Game: n/a
- Christian McCaffrey, RB – Last Game: n/a
- George Kittle, TE – Last Game n/a
Los Angeles Rams
- Matthew Stafford, QB – Last Game: n/a
- Puka Nacua, WR – Last Game: n/a
- Kyren Williams, RB – Last Game: n/a
Week 1 Thursday Night Football – San Francisco 49ers vs. Los Angeles Rams Injuries
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Thursday Night Football Schedule, Game Lines & Betting Results
- SU (Favorite-Underdog): 0-0
- ATS (Favorite-Underdog): 0-0
- O/U (Over-Under): 0-0
Week 1 (Sept. 10) *Melbourne, Australia
- San Francisco 49ers vs. Los Angeles Rams (, ) – 8:35 p.m. (Netflix)
Week 2 (Sept. 17)
- Detroit Lions at Buffalo Bulls – 8:15 p.m.
Week 3 (Sept. 24)
- Atlanta Falcons at Green Bay Packers – 8:15 p.m.
Week 4 (Oct. 1)
- Pittsburgh Steelers at Cleveland Browns – 8:15 p.m.
Week 5 (Oct. 8)
- Tampa Bay Buccaneers at Dallas Cowboys – 8:15 p.m.
Week 6 (Oct. 15)
- Seattle Seahawks at Denver Broncos – 8:15 p.m.
Week 7 (Oct. 22)
- New England Patriots at Chicago Bears – 8:15 p.m.
Week 8 (Oct. 29)
- Carolina Panthers at Green Bay Packers – 8:15 p.m.
Week 9 (Nov. 5)
- Jacksonville Jaguars at Baltimore Ravens – 8:15 p.m.
Week 10 (Nov. 12)
- Washington Commanders at New York Giants – 8:15 p.m.
Week 11 (Nov. 19)
- Indianapolis Colts at Houston Texans – 8:15 p.m.
Week 12 (Nov. 26) *Thanksgiving Week
- Kansas City Chiefs at Buffalo Bills – 8:20 p.m. (NBC)
Week 13 (Dec. 3)
- Kansas City Chiefs at Los Angeles Rams – 8:15 p.m.
Week 14 (Dec. 10)
- Minnesota Vikings at New England Patriots – 8:15 p.m.
Week 15 (Dec. 17)
- San Francisco 49ers at Los Angeles Chargers – 8:15 p.m.
Week 16 (Dec. 24)
- Houston Texans at Philadelphia Eagles – 8:15 p.m.
Week 17 (Dec. 31)
- Baltimore Ravens at Cincinnati Bengals – 8:15 p.m.
