1:56 pm EDT, 10/4Highmark Stadium • Orchard Park, NY
Depth Chart
1:56 pm EDT, 10/4Highmark Stadium • Orchard Park, NY
Depth Chart
Buffalo Bills vs New England Patriots Matchup
Game Overview
Today's Odds
MoneylineSpreadOver/Under
BUF ML-316
BUF Spread-6.5 -116
O/U48.5 -112/-108
NE Spread+6.5 -105
NE ML+253
Odds ComparisonNEMLBUF
DraftKings+253####-316
Consensus+253####-316
William Hill+250####-316
FanDuel+265####-316
BetMGM+260####-316
Bet Splits
Patriots Vs. Bills Betting Record
Head To Head History
Last 6 Matchups
| 12/14/25 | vs | |||
| 10/5/25 | @ | |||
| 1/5/25 | vs | |||
| 12/22/24 | @ | |||
| 12/31/23 | @ | |||
| 10/22/23 | vs |
| 12/14/25 | vs | |||
| 10/5/25 | @ | |||
| 1/5/25 | vs | |||
| 12/22/24 | @ | |||
| 12/31/23 | @ | |||
| 10/22/23 | vs |
