8:20 pm EST, 12/1Highmark Stadium • Orchard Park, NY
Depth Chart
8:20 pm EST, 12/1Highmark Stadium • Orchard Park, NY
Depth Chart
Buffalo Bills vs San Francisco 49ers Matchup
Game Overview
Today's Odds
MoneylineSpreadOver/Under
BUF ML+105
BUF Spread-6.5 -110
O/U45.5 -110/-111
SF Spread+6.5 -110
SF ML+252
Odds ComparisonSFMLBUF
DraftKings+275####+105
Consensus+252####+105
William Hill+270####-350
FanDuel+240####-350
BetMGM+260####-350
Bet Splits
49ers Vs. Bills Betting Record
Head To Head History
Last 6 Matchups
| 12/7/20 | vs | |||
| 10/16/16 | @ | |||
| 10/7/12 | vs | |||
| 11/29/08 | @ | |||
| 12/25/04 | vs | |||
| 12/1/01 | vs |
| 12/7/20 | vs | |||
| 10/16/16 | @ | |||
| 10/7/12 | vs | |||
| 11/29/08 | @ | |||
| 12/25/04 | vs | |||
| 12/1/01 | vs |
