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Best MLB Home Run Predictions, Picks, Props, Odds for Sunday, April 12, 2026

Check out the best MLB home run picks and predictions for games on Sunday, April 12 with odds and insights provided by Lineups.com.
Corey Seager
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We snapped our cold streak on Saturday, as Brandon Nimmo went yard off Emmet Sheehan, making it a profitable night, even though we missed on Bobby Witt Jr. and Vladimir Guerrero Jr.

Today, we’re riding with Gunnar Henderson, Konnor Griffin, and Corey Seager.

Keep reading to find out about our MLB home run predictions for today. Also, be sure to check out our daily MLB betting trends page.

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2026 MLB HR Props Record: 4-39 (-1.46 units) 

Home Run Prop Predictions & Odds: MLB HR Best Bets for Saturday, April 11

Gunnar Henderson Home Run Odds

Gunnar Henderson is off to a terrific start to the season, slashing .246/.348/.614 with six home runs in 66 plate appearances. Coming into Saturday’s action, Henderson had excellent batted ball metrics, as highlighted by a 13.9% barrel rate.

The Orioles’ superstar shortstop has been red-hot at the plate, homering three times in his last four games.

Up next is an exploitable matchup against Giants’ right-hander Adrian Houser, who is allowing a .496 wOBA against lefties like Henderson this season.

Then you have to consider that this game is in a hitter-friendly environment at Camden Yards. When you combine each of these factors, you come away feeling like this is a good value at over +500 odds at the time of this article. Risk 0.1 units.

Konnor Griffin Home Run Odds

I wanted to target a hitter in the Pirates vs Cubs game because the wind is blowing out at Wrigley, which is why the total is set so high at 12 runs at the time of this article. While Oneil Cruz is my favorite, he’s simply too expensive. The best value on the board for Pittsburgh looks like the top prospect in baseball, none other than Konnor Griffin.

Griffin hasn’t homered yet, but he’s shown off his elite bat speed, with a maximum exit velocity at 113.2 MPH so far.

On top of favorable weather conditions, it’s a good matchup against Jameson Taillon. The veteran right-hander is allowing an 11.8% barrel rate, which ranks in the 28th percentile.

Giving up a lot of hard contact with extreme weather conditions is a bad combination. We could see the Pirates pour on runs in this one. Why not take a shot on Griffin to see if he can hit his first career home run? Risk 0.1 units.

Corey Seager Home Run Odds

Corey Seager has been relatively solid to start the year, slashing .220/.317/.460 with four home runs. The veteran shortstop already has one home run in this series against his former team, the Dodgers. I’m betting that he can do it again here. I’m willing to take Seager at short odds in this spot.

I love the matchup against Dodgers right-hander Roki Sasaki, who is really struggling right now. The second-year righty has allowed a 4.72 xERA and 11.1% barrel rate (31st percentile), which is a bad combination.

On top of that, Sasaki has been much worse against lefties, allowing a .415 wOBA and 2.57 HR/9.

There’s a decent chance that this will be Sasaki’s final start before he’s sent down to the minors. He’s on thin ice right now, especially off a six-run outing against the Nationals, where he gave up two homers.

We’ll bet on Seager hitting No. 5 on the season here. Risk 0.1 units.

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Photo Credit: AP/Mark J. Terrill

About the Author
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Frank Ammirante has been creating sports betting and fantasy sports content for 5+ years, specializing in baseball and football, but also writing about basketball, hockey, and soccer. He has also written online casino, sweepstakes casino, prediction markets, and news articles while working as a content editor as well. You may have seen his work at The Game Day, RotoBaller, FantasyPros, Deadspin, Casino.org, and much more. Frank started out in the fantasy sports space and has competed in popular industry events like Tout Wars. His work has recently been published in this year's Fantasy Index fantasy baseball magazine. As an avid Blue Jays fan, Frank is still mourning their World Series loss to the Dodgers, calling it "one of the biggest collapses in sports history."

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