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Best Bet: Under 41.5 (-118) at DraftKings
Score Prediction: Iowa 24, Iowa State 17
The Pick: Iowa 24, Iowa State 17
The Under 41.5 total points at -118 is our pick for this game, a traditionally low scoring head-to-head with the only Over hitting in the last five meetings set at 36.
Game Betting Analysis
The betting data is overwhelmingly in favor of the Under, as this Cy-Hawk meeting is a regular one despite non-conference game status. In the last five meetings, the Under has hit four times with the last four head-to-heads seeing the winning team score a maximum 20 points. These past game totals have included 39, 34.5, 36 and last year 43. The game total at 36 was the one Over. Iowa State, a more finite trend, has seen the Under hit in 7 of 8 games against schools from Iowa. So it’s difficult to go away from the much support when we also get 41.5 for Saturday.
Iowa State-Iowa Odds (Spread, Moneyline, Over/Under)
Deciding Factor: Kamari Moulton vs. Sullivan Schlimgen
Running back Kamari Moulton is the reason for Iowa’s success on offense in Week 1, with nearly 200 rushing yards and a pair of TDs. While Iowa’s quarterback play once again seems to be in neutral, Tony Diaz was able to stand out in the receiving game. However, Moulton will need to produce against a defense led by Sullivan Schlimgen who saw a great Week 1 game with nine tackes and a sack. While he will be the one to watch in the box against Moulton, both Carson Willich and Jack Janikowski also saw productive Week 1 games. They will need to assist Schlimgen and the front unit in stopping Iowa’s main threat on the ground.
Game Information
- Date: Saturday, September 12, 2026
- Kickoff: 7:30 p.m. ET
- Network: NBC
- Venue: Kinnick Stadium – 40 ppg; 0-1 O/U
Best Bets for College Football Week 2
- Under 41.5 (-118)
Key Players
Iowa State Cyclones
- QB, Jaylen Raynor — Last Game: 8/16, 184 yards, 2 TD; 7 carries, 32 yards, 2 TD
- LB, Sullivan Schlimgen — Last Game: 9 tackles, 1 sack, 1 TFL
Iowa Hawkeyes
- RB, Kamari Moulton — Last Game: 11 carries, 183 yards, 2 TD
- WR, Tony Diaz — Last Game: 7 catches, 84 yards, TD
Photo Credit: REUTERS
