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A huge ACC vs. SEC showdown is set to close out college football action on Sunday with the Louisville Cardinals facing the Ole Miss Rebels from Nissan Stadium in Nashville, Tennessee. Let’s dive into the betting data, odds, trends and insights for this early CFB Playoff implication matchup.
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Louisville vs. Ole Miss Game Betting Analysis
We’ll start with the total since that’s what the data is pointing towards, as Ole Miss has hit the Under in six straight games when facing an AP ranked school as the favorite. Louisville has also hit the Under in four of five games as the underdog but there is a lot of Over data as well. Ole Miss has gone Over the total in four straight games on a neutral site and while Louisville has the Under trend as an underdog, the Cardinals are a bit deceiving as they have gone Over in five of six games when playing on a neutral site as underdogs.
So as you can see, we’ve hit a wall in the total market. We move to the spread where Ole Miss has covered five of six games against the ACC, but Louisville has also covered the spread in four of five games as the underdog. A finite piece of data shows the team ranked 9th in the AP Poll has covered seven of eight games. While we’re not high on either, we’ll take the Rebels to cover along with the Over which has support for both schools on a neutral site.
Louisville vs. Ole Miss Game Best Bet, Pick & Prediction
Best Bet: UL/OMISS O54.5 (-105) at DraftKings
Best Bet: Ole Miss -6.5 (-115)
Score Prediction: Ole Miss 31, Louisville 24
Louisville vs. Ole Miss Game Odds
Louisville vs. Ole Miss Game Information
- Date: Sunday, September 6, 2026
- Time: 7:30 p.m. ET
- Network: ABC
- Location: Nashville, Tennessee
- Venue: Nissan Stadium – n/a
Louisville vs. Ole Miss Game Betting Resources
- College Football Betting Trends
- CFB Playoffs Futures Markets
- College Football Game Odds
- National Championship Odds
- Heisman Trophy Futures Market
Louisville vs. Ole Miss Game Key Players
Louisville
- Lincoln Keinholz, QB – Last Game: n/a
- Isaac Brown, RB – Last Game: n/a
- Clev Lubin, DL – Last Game: n/a
Ole Miss
- Trinidad Chambliss, QB – Last Game: n/a
- Kewan Lacy, RB – Last Game: n/a
- Will Echoles, DT – Last Game: n/a
Photo Credit: REUTERS
