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Best Bet: Ole Miss ML (+130) at DraftKings
Score Prediction: Ole Miss 31, LSU 27
The Pick: Ole Miss 31, LSU 27
Game Betting Analysis
Looking at the data two things stand out, the total is all over the place and tough to nail down – while the other is that the home team thrives in this series. The home team has covered the spread in a remarkable eight straight meetings, along with 12 of the last 13 head-to-heads as well. Ole Miss is the home underdog with former head coach leaving for LSU, now returning in what will be a very emotional night inside Vaught-Hemmingway Stadium. Not only do the head-to-head trends side with Ole Miss here, but Ole Miss itself provides data worth backing – winning an insane 14 straight games when playing in the state of Mississippi. Of yeah, LSU’s Sam Leavitt might not play. Good luck chuck, we’ll cross our fingers and take the home dog here.
LSU-Ole Miss Odds (Spread, Moneyline, Over/Under)
Deciding Factor: Sam Leavitt’s Health vs. Golding’s Revenge
Everything about this game points to LSU’s defense and Lane Kiffin’s return to Oxford being the storylines — but the real deciding factor is Sam Leavitt’s shoulder. LSU’s QB was doubtful earlier in the week with an upper-body injury before an upgrade to questionable, and that uncertainty is exactly why the line has moved off LSU and toward Ole Miss. If Leavitt isn’t right, LSU turns to Landen Clark or Husan Longstreet — a real drop-off against a Rebels defense playing at home in the biggest game Oxford has hosted in decades.
Ole Miss brings its own case regardless of Leavitt’s status. The Rebels needed a 41-38 shootout to get past Louisville, but that offense — Trinidad Chambliss and Kewan Lacy — has shown it can put points on the board in bunches, and Pete Golding knows this LSU program and Kiffin’s tendencies better than anyone on the other sideline. With the line already shading toward Ole Miss and a genuine QB question mark hanging over LSU, this is our lean in the Rebels’ favor.
Game Information
- Date: Saturday, September 19, 2026
- Kickoff: 7:30 p.m. ET
- Network: ABC
- Venue: Vaught-Hemmingway Stadium – 50 ppg; 0-1 O/U
Best Bets for College Football Week 3
- Ole Miss ML (+130)
Key Players
LSU Tigers
- QB, Sam Leavitt — Last Game: 25/38, 344 yards, TD, 3 INT; 11 carries, 22 yards, 3 TD
- TE, Trey’Dez Green — Last Game: 6 catches, 104 yards, TD
Ole Miss Rebels
- QB, Trinidad Chambliss— Last Game: 23/26, 225 yards, 2 TD
- RB, Kewan Lacy — Last Game: 13 carries, 87 yards, 2 TD
Photo Credit: REUTERS
