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MLB Home Run Picks Today: Brandon Lowe, Vinnie Pasquantino & Brooks Lee Best Bets

Today’s best MLB home run picks — Vinnie Pasquantino, Brooks Lee and Brandon Lowe — with matchups and betting angles for tonight’s slate.
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Top HR Picks: Brandon Lowe , Vinnie Pasquantino & Brooks Lee

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Home Run Prop Predictions & Odds: MLB HR Best Bets for Tuesday, September 22nd

Tuesday’s slate offers a strong crop of anytime home run targets, and three bats stand out above the rest. Vinnie Pasquantino is in the middle of a scorching September for Kansas City, Brooks Lee just cracked the 20-homer mark for the first time in his career, and Brandon Lowe has quietly put together a career year in Pittsburgh. Below, we break down the matchup, recent form, and betting angle for each of these three MLB home run picks today.

Brandon Lowe (Pirates vs. Cardinals) Home Run Odds

Lowe has been a revelation in Pittsburgh, posting a career year with 32 home runs, a .488 slugging percentage, and a personal-best 5.4 bWAR in 626 plate appearances. The underlying numbers back up the power surge — his 12.1% barrel rate and 45.4% hard-hit rate both sit well above league average, and his 91.0 mph average exit velocity and .436 xSLG point to a legitimately elite power profile rather than a hot streak.

Vinnie Pasquantino (Royals vs. White Sox) Home Run Odds

Pasquantino is red-hot in September, hitting five home runs and driving in 13 runs across his first 17 games of the month, including his 14th long ball of the season Sunday against the Pirates. He gets a Chicago staff Tuesday that’s allowing home runs at one of the higher clips in the league, with White Sox righty Anthony Kay on the mound opposite Kansas City’s Daniel Lynch IV. Pasquantino’s second-half power surge plus a soft opposing pitching matchup make him one of the more attractive anytime home run plays on the board tonight.

Brooks Lee (Twins vs. Giants) Home Run Odds

Lee has cleared 20 home runs for the first time in his career and is riding a strong September, hitting .290/.320/.377 through his first 18 games of the month with three hits in his last outing against the Angels. He’s been considerably more dangerous on the road (.866 OPS away from Target Field compared to .597 at home) and thrives against right-handed pitching — a combination that lines up well as the Twins visit Oracle Park to face Giants righty Anthony Molina on Tuesday.

Photo Credit: REUTERS

About the Author
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Thom Cunningham is the Lineups.com News Editor and has been involved with sports media for almost two decades at Spectrum, VegasInsider.com, Oddschecker, VSiN and much more as a content producer - focused on the betting and gaming space over the last decade tracking insights, data analytics and covering various markets from the NFL to the Oscars. 

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