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MLB Home Run Predictions, Picks, Props, Odds for Friday, April 17, 2026

Check out the best MLB home run picks and predictions for games on Friday, April 17 with odds and insights provided by Lineups.com.
Yordy Alvarez
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We nailed Jose Ramirez to go yard on Thursday, making it a profitable day. We’ll look to keep it rolling on Friday’s slate.

Today, we’re going with Yordan Alvarez, Austin Riley, and Willy Adames. Each of these hitters has a strong track record and is in a favorable situation to hit home runs.

Keep reading to find out about our MLB home run predictions for today. Also, be sure to check out our daily MLB betting trends page.

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2026 MLB HR Props Record: 6-52 (-2.45 units) 

Home Run Prop Predictions & Odds: MLB HR Best Bets for Friday, April 17

Yordan Alvarez Home Run Odds

Yordan Alvarez has been an absolute monster this season, slashing .328/.483/.731 with seven home runs in 89 plate appearances. The plate discipline metrics look phenomenal: 20.2% walk rate, 11.2% strikeout rate. The batted ball numbers are even better: 20.7% barrel rate.

The matchup is on point as well, as Alvarez goes up against Cardinals right-hander Kyle Leahy, who has been disappointing so far, allowing an 8.30 xERA and 16.7% barrel rate. Left-handed hitters have crushed Leahy so far, putting up a .481 wOBA (right-handers have a .226 wOBA against him).

With Alvarez mashing, I’m surprised that we’re able to get him at longer than +300 odds given this favorable matchup. Risk 0.1 units.

Austin Riley Home Run Odds

Austin Riley is off to a slow start, slashing .229/.316/.329 with one home run in 79 plate appearances. However, the plate discipline looks good (11.4 BB%, 17.7 K%). Plus, Riley has an extensive track record, with three 30+ home run seasons under his belt.

On top of that, Riley’s first home run of the season came in his last game, so perhaps this could be the start of a hot streak. There are encouraging signs, as he’s hit safely in five of his last seven games.

Up next is a good spot against Taijuan Walker, who has a 6.59 xERA with a 2.45 HR/9 this season. It’s definitely the right matchup for Riley to hit his second homer of the season, especially in a projected high-scoring game with a 9.5-run total. Risk 0.1 units.

Willy Adames Home Run Odds

Willy Adames is off to a rock-solid start at the plate, slashing .260/.316/.507 with three home runs in 79 plate appearances. The veteran shortstop is hitting the ball hard, as highlighted by an 11.5% barrel rate.

We’re starting to see Adames heat up at the plate, as he’s gone 12-for-36 (.333 BA) with two home runs in his last nine games. He’s got a good matchup next against Nationals’ right-hander Zack Littell.

The former Reds’ innings-eater has put up a 5.35 xERA with a 9.8% barrel rate so far. Even better for this prop is that Littell has already allowed five home runs in only 15 innings.

With that in mind, we’ll take a shot on Adames to hit No. 4 tonight. Risk 0.1 units.

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About the Author
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Frank Ammirante

Senior Staff Writer

Frank Ammirante has spent the last 5+ years covering sports betting, fantasy sports, and the wider iGaming industry, with a focus on MLB and NFL betting alongside fantasy baseball and football strategy, as well as basketball, hockey, and soccer. His work has appeared on outlets like The Game Day, RotoBaller, FantasyPros, Deadspin, and Pro Football Network, and more, where he's covered everything from player props and betting futures to online casino and sweepstakes casino reviews, prediction markets, and industry news. He also brings hands-on editorial experience as a content editor elsewhere in the industry. Frank started out in the fantasy sports space, and today he's a member of the Fantasy Sports Writers Association who competes in some of the industry's toughest expert fantasy leagues, including Tout Wars, Scott Fish Bowl, and The Great Fantasy Baseball Invitational. He's an annual competitor in Tout Wars specifically, and his fantasy baseball rankings have been featured in Fantasy Index's fantasy baseball magazine. Off the clock, he's a die-hard Toronto Blue Jays and Washington Commanders fan who still isn't quite over the Blue Jays' World Series loss to the Dodgers, which he's called "one of the biggest collapses in sports history."

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