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MLB Home Run Predictions, Picks, Props, Odds for Saturday, May 16, 2026

Check out the best MLB home run picks and predictions for games scheduled on Friday, May 15 with odds and insights from Lineups.com.
Jordan Walker
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We were shut out on Friday, as Yordan Alvarez and Bobby Witt Jr. each failed to homer, while Byron Buxton had the day off.

We’ll look to get back on track for the Saturday slate, where we’re riding with Jordan Walker, Curtis Mead, and Munetaka Murakami.

Remember to be sure to check out our daily MLB betting trends page.

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2026 MLB HR Props Record: 26-117 (-1.31 units) 

Home Run Prop Predictions & Odds: MLB HR Best Bets for Saturday, May 16

Jordan Walker Home Run Odds

Jordan Walker is having a terrific season, establishing himself as one of the biggest breakouts of 2026. The Cardinals’ outfielder is currently slashing .294/.370/.575 with 12 home runs in 181 plate appearances coming into Friday’s action. He’s homered in back-to-back games, so he’s in a groove at the plate right now.

This is a hitter who is absolutely crushing the ball this year, as highlighted by an impressive 18.0% barrel rate. Walker has been even better against left-handed pitchers, putting up a .378 ISO, which is good news because he’ll get one up next in Noah Cameron.

The Royals’ lefty has struggled this season, registering a 6.40 xERA and allowing a 13.6% barrel rate. We’re also getting favorable weather in St. Louis, with forecasts calling for 78-degree temperatures with 10.7 MPH winds blowing out to left-center.

Considering these factors, it’s a good spot to ride with Walker to hit a home run. Risk 0.1 units.

Curtis Mead Home Run Odds (+700)

Here we have a longshot home run prop for you with Curtis Mead. The former Rays prospect is currently slashing .227/.346/.443 with four home runs in 104 plate appearances. He’s quietly showed some improvements at the plate, bumping up his walk rate from 5.7% to 13.5% while cutting his strikeout rate from 23.9% to 16.3%.

On top of that, Mead is hitting the ball much harder, improving his barrel rate from 4.5% to 9.9%. While he hasn’t homered since April 29th, I like the spot for him against the Orioles here.

Chris Bassitt is on the mound for Baltimore. The veteran righty has registered a 5.03 xERA this season. We’re also getting favorable weather here, with forecasts projecting 84-degree temperatures with 9.3 MPH winds blowing out to center.

It’s also worth noting that Mead is 2-for-3 with one home run against Bassitt in his career, which is a nice “cherry on top” for this play. Risk 0.1 units.

Munetaka Murakami Home Run Odds

Munetaka Murakami has exceeded expectations in coming to MLB, slashing .227/.371/.533 with 15 home runs in 186 plate appearances. While the strikeout rate remains an issue (33.9%), the barrel rate is off the charts at 22.7%. The White Sox first baseman simply crushes the ball.

Up next is an exploitable matchup against Cubs’ right-hander Jameson Taillon. The veteran has 4.22 xERA and a 2.17 HR/9 this season. He’s giving up a ton of hard contact, as highlighted by a 13.3% barrel rate.

Lefties have been going yard quite often against Taillon, as he’s giving up a 2.53 HR/9. With that in mind, it’s a good spot to take a shot on Murakami to hit his 16th homer of the year. He’s facing a home run-prone hitter who is worse against lefties. Risk 0.1 units.

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About the Author
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Frank Ammirante

Senior Staff Writer

Frank Ammirante has spent the last 5+ years covering sports betting, fantasy sports, and the wider iGaming industry, with a focus on MLB and NFL betting alongside fantasy baseball and football strategy, as well as basketball, hockey, and soccer. His work has appeared on outlets like The Game Day, RotoBaller, FantasyPros, Deadspin, and Pro Football Network, and more, where he's covered everything from player props and betting futures to online casino and sweepstakes casino reviews, prediction markets, and industry news. He also brings hands-on editorial experience as a content editor elsewhere in the industry. Frank started out in the fantasy sports space, and today he's a member of the Fantasy Sports Writers Association who competes in some of the industry's toughest expert fantasy leagues, including Tout Wars, Scott Fish Bowl, and The Great Fantasy Baseball Invitational. He's an annual competitor in Tout Wars specifically, and his fantasy baseball rankings have been featured in Fantasy Index's fantasy baseball magazine. Off the clock, he's a die-hard Toronto Blue Jays and Washington Commanders fan who still isn't quite over the Blue Jays' World Series loss to the Dodgers, which he's called "one of the biggest collapses in sports history."

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