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MLB Home Run Predictions, Picks, Props, Odds for Wednesday, April 22, 2026

Check out the best MLB home run picks and predictions for Wednesday, April 22 with odds and insights provided by Lineups.com.
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We cooled off on Tuesday, getting shut out on Jac Caglianone, Kyle Manzardo, and Alex Bregman. Let’s try to get back on track with the Wednesday slate.

Today, we’re going with Matt Olson, Willson Contreras, and Logan O’Hoppe. Each of these hitters is hitting the ball hard and in the air lately.

Keep reading to find out about our MLB home run predictions for today. Also, be sure to check out our daily MLB betting trends page.

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2026 MLB HR Props Record: 10-63 (-1.66 units) 

Home Run Prop Predictions & Odds: MLB HR Best Bets for Wednesday, April 22

Matt Olson Home Run Odds

Matt Olson is off to a terrific start to the season. Entering Tuesday’s action, Olson had a .278/.365/.589 slash with six home runs in 104 plate appearances. This includes an impressive 20.3% barrel rate and a 45.3% hard-hit rate.

We’ve seen Olson homer twice in his last six games. He’s also put up a 63.2% fly ball rate (8th) and a 47.4% hard-hit rate (30th) in the last seven days.

You have to like the matchup against Nationals’ right-hander Zack Littell. The veteran just got rocked for eight earned runs against the Giants in his last outing. Littell has now allowed seven home runs in 19 innings this year.

Lefties have been even more of a problem for Littell, as he’s giving up a .446 wOBA and a 4.66 HR/9 against them.

It’s a great spot for Olson, so we’ll take him to homer for the seventh time this season. Risk 0.1 units.

Willson Contreras Home Run Odds

Willson Contreras came into Tuesday’s action with a .274/.404/.466 slash with four home runs in 89 plate appearances. He’s making a lot of hard contact, including a 16.7% barrel rate and a 47.9% hard-hit rate.

On top of that, just like Olson, Contreras is hitting the ball in the air (60.0% fly ball rate) while making hard contact (40.0% hard-hit rate) in the last seven days.

While it’s a tough matchup against Yankees’ left-hander Max Fried, Contreras has hit lefties well throughout his career, putting up a 136 wRC+ (118 wRC+ vs. righties). Plus, Fried hasn’t been his usual self so far, as highlighted by the 4.17 SIERA.

With that in mind, we’ll ride with Contreras to go yard in this spot. Risk 0.1 units.

Logan O’Hoppe Home Run Odds

Logan O’Hoppe entered Tuesday’s game against the Blue Jays with a .197/.316/.258 slash with one home run in 79 plate appearances. The overall numbers aren’t good, but I like the batted ball metrics, including a 10.6% barrel rate and a 114.3 MPH maximum exit velocity.

Just like the other names on this list, O’Hoppe has been putting the ball in the air (60.0% fly ball rate) in the last seven days. He’s going up against lefty Eric Lauer in this spot. Lauer is allowing a 2.04 HR/9 and a 9.4% barrel rate so far this year.

So, here we have a hitter who is lifting the ball, facing a pitcher who has struggled with home runs.

Add in the fact that we’re getting longshot odds since this is a hitter off to a slow start, and you can see why this looks appealing. Let’s take a shot on O’Hoppe here. Risk 0.1 units.

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About the Author
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Frank Ammirante

Senior Staff Writer

Frank Ammirante has spent the last 5+ years covering sports betting, fantasy sports, and the wider iGaming industry, with a focus on MLB and NFL betting alongside fantasy baseball and football strategy, as well as basketball, hockey, and soccer. His work has appeared on outlets like The Game Day, RotoBaller, FantasyPros, Deadspin, and Pro Football Network, and more, where he's covered everything from player props and betting futures to online casino and sweepstakes casino reviews, prediction markets, and industry news. He also brings hands-on editorial experience as a content editor elsewhere in the industry. Frank started out in the fantasy sports space, and today he's a member of the Fantasy Sports Writers Association who competes in some of the industry's toughest expert fantasy leagues, including Tout Wars, Scott Fish Bowl, and The Great Fantasy Baseball Invitational. He's an annual competitor in Tout Wars specifically, and his fantasy baseball rankings have been featured in Fantasy Index's fantasy baseball magazine. Off the clock, he's a die-hard Toronto Blue Jays and Washington Commanders fan who still isn't quite over the Blue Jays' World Series loss to the Dodgers, which he's called "one of the biggest collapses in sports history."

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