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MLB Home Run Predictions, Picks, Props, Odds for Wednesday, May 6, 2026

Check out the best MLB home run picks and predictions for games on Wednesday, May 6 with odds and insights provided by Lineups.com.
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We had another profitable night on Tuesday, as Bryce Harper went yard to make up for James Wood and Jac Caglianone missing.

Today, we’re riding with Shohei Ohtani, Munetaka Murakami, and Matt Olson. Let’s see if we can make it a third winning slate in a row.

Remember to be sure to check out our daily MLB betting trends page.

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2026 MLB HR Props Record: 20-95 (-1.2 units) 

Home Run Prop Predictions & Odds: MLB HR Best Bets for Wednesday, May 6

Shohei Ohtani Home Run Odds

Shohei Ohtani has been a bit disappointing at the plate this season, slashing .240/.382/.432 with six home runs in 158 plate appearances. These are way below career norms. It appears that the idea that Ohtani doesn’t hit as well when he’s pitching for a full year is starting to look bang on.

With that said, it’s only a matter of time before Ohtani starts swinging a hot bat. The batted ball metrics still look fantastic, as highlighted by an 18.5%. barrel rate. He’s currently in a 0-for-24 slump, but I like him to get back on track vs. Lance McCullers Jr.

The Astros’ righty has a 4.37 xERA on the season, allowing a 1.15 HR/9 and an 8.6% barrel rate. The numbers are even worse against lefties like Ohtani, including a 1.56 HR/9.

With that in mind, this looks like the ideal spot for Ohtani to go yard for the seventh time this season. Risk 0.1 units.

Munetaka Murakami Home Run Odds

Munetaka Murakami has shattered preseason expectations in the first month of his big league career, slashing .244/.378/.583 with 14 home runs in 156 plate appearances.

He’s striking out at a very high rate (32.7 K%), but the walk rate has been otherworldly (17.9 BB%). You also have to love the 22.1% barrel rate.

Murakami has been one of the hottest hitters in baseball of late, homering nine times in his last 17 games. We’ve got favorable weather at Angels Stadium, with forecasts calling for 7.6 MPH winds blowing out, so it’s a favorable spot for Murakami.

While today’s starter, Walbert Urena, has done a good job limiting hard contact, Murakami can homer off any pitcher with his elite raw power. With as hot as he’s been, we have to ride with him in this spot.

Bet on Murakami to hit his 15th homer of the season. Risk 0.1 units.

Matt Olson Home Run Odds

Matt Olson is having a major bounce-back season, slashing .308/.392/.685 with 13 home runs in 166 plate appearances. This includes an elite 19.4% barrel rate, so Olson is absolutely crushing the ball.

The veteran first baseman is in top form right now, homering in six of his last nine games.

While the matchup is tough on paper vs. Bryan Woo, the Mariners’ right-hander lately. In his last two starts, Woo has given up a combined 13 earned runs, with six home runs.

There’s a chance that something is up with Woo right now. It’s unlike him to get rocked two games in a row. There’s a slight chance that he’s pitching through an injury.

With how well Olson is hitting right now, we’re going with him to hit No. 14 here. Risk 0.1 units.

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About the Author
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Frank Ammirante

Senior Staff Writer

Frank Ammirante has spent the last 5+ years covering sports betting, fantasy sports, and the wider iGaming industry, with a focus on MLB and NFL betting alongside fantasy baseball and football strategy, as well as basketball, hockey, and soccer. His work has appeared on outlets like The Game Day, RotoBaller, FantasyPros, Deadspin, and Pro Football Network, and more, where he's covered everything from player props and betting futures to online casino and sweepstakes casino reviews, prediction markets, and industry news. He also brings hands-on editorial experience as a content editor elsewhere in the industry. Frank started out in the fantasy sports space, and today he's a member of the Fantasy Sports Writers Association who competes in some of the industry's toughest expert fantasy leagues, including Tout Wars, Scott Fish Bowl, and The Great Fantasy Baseball Invitational. He's an annual competitor in Tout Wars specifically, and his fantasy baseball rankings have been featured in Fantasy Index's fantasy baseball magazine. Off the clock, he's a die-hard Toronto Blue Jays and Washington Commanders fan who still isn't quite over the Blue Jays' World Series loss to the Dodgers, which he's called "one of the biggest collapses in sports history."

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