Over the last few seasons, Zach LaVine was one of the more notable injuries. He tore his ACL, and it led to Minnesota eventually sending him off to Chicago in return for Jimmy Butler. Later on, Butler had an injury to his meniscus where he missed some time but eventually came back full strength. It is wild to think we have seen teams move on so quickly from younger talent that suffered a major injury, and teams also so eager to pick them up.
In the early 2000s Sam Cassell had a hamstring injury that caused him to miss a good portion of the second half. Al Jefferson was on the team back in 2009, and suffered a major injury tearing his ACL. Jefferson would never quite be the same after that, and his prime was on the way out anyway. This was a pretty severe loss for Minnesota given the depth at the time was not that great. Once Kevin Love got to Minnesota, he broke his left hand in the 2009 season. He was out for a few months with this requiring surgery. Love also broke his hand later on in 2012.
Nikola Pekovich battled injuries throughout his career, and just never quite settled into Minnesota. His career was eventually cut short due to nagging injuries, but more so because Minnesota was done relying on him. The big injury was him having surgery on his right ankle. He also was phased out of what became a new NBA for centers. Malcolm Lee was one of the younger players for the Timberwolves at the time, and he tore his meniscus back in 2011. Lee never quite recovered and was eventually passed up on the depth chart. Ricky Rubio lost the 2012 season and some of 2013 with a torn ACL. Rubio ended up making a full recovery. He later on had surgery on his ankle in 2015, which eventually ended his time in Minnesota.
Kevin Martin fractured his wrist at the beginning of the 2014 season, Martin never quite made a full recovery and while he played for a few more years, he was not that effective. The Timberwolves thought highly of Shabazz Muhammad coming out of the draft, but some injuries including a ligament tear in his hand caused him to miss most of his time in Minnesota.