The Chiefs will look different this year after trading away Tyreek Hill over the offseason, and they will have to hit the ground running with a difficult early-season slate without their former All-Pro wide receiver. The Chiefs start with three of their first four games on the road against the Cardinals, Colts, and Buccaneers with a home game on Thursday Night Football against the Chargers in that stretch. Kansas City’s schedule then takes them back home to face the Raiders and Bills before a road game against the 49ers. Following their Week 8 bye, they have a Sunday Night Football matchup against the Titans. The toughest stretch of the season for the Chiefs might come in late November and early December when they face the two Super Bowl teams from last year, the Rams (home) and Bengals (road), and travel to play the Chargers and Broncos all in a four-week stretch. The Chiefs are tied for the fifth-toughest schedule in the NFL this year and Patrick Mahomes will need to be in MVP form for them to survive.

WK	Date	Time	Opponent	Spread	Moneyline	Total	Score	Record	Matchup
1	9/11/22	8:25 pm	at ARI Cardinals Arizona Cardinals	KC -6.0	KC -250/ARI +210	O/U 54.0	44-21	1 - 0	Chiefs at Cardinals
2	9/16/22	12:15 am	vs LAC Chargers Los Angeles Chargers	KC -4.0	LAC +165/KC -195	O/U 52.5	27-24	2 - 0	Chiefs vs Chargers
3	9/25/22	5:00 pm	at IND Colts Indianapolis Colts	KC -5.0	KC -240/IND +200	O/U 51.0	17-20	2 - 1	Chiefs at Colts
4	10/3/22	12:20 am	at TB Buccaneers Tampa Bay Buccaneers	TB -2.0	KC +105/TB -125	O/U 47.0	41-31	3 - 1	Chiefs at Buccaneers
5	10/11/22	12:15 am	vs OAK Raiders Las Vegas Raiders	KC -7.0	OAK +290/KC -350	O/U 51.5	30-29	4 - 1	Chiefs vs Raiders
6	10/16/22	8:25 pm	vs BUF Bills Buffalo Bills	BUF -2.5	BUF -150/KC +130	O/U 54.0	20-24	4 - 2	Chiefs vs Bills
7	10/23/22	8:25 pm	at SF 49ers San Francisco 49ers	KC -1.0	KC -115/SF -105	O/U 48.5	44-23	5 - 2	Chiefs at 49ers
8	BYE WEEK
9	11/7/22	1:20 am	vs TEN Titans Tennessee Titans	KC -14.0	TEN +550/KC -750	O/U 45.0	20-17	6 - 2	Chiefs vs Titans
10	11/13/22	6:00 pm	vs JAX Jaguars Jacksonville Jaguars	KC -9.5	JAX +360/KC -450	O/U 51.5	27-17	7 - 2	Chiefs vs Jaguars
11	11/21/22	1:20 am	at LAC Chargers Los Angeles Chargers	KC -5.5	KC -230/LAC +195	O/U 52.5	30-27	8 - 2	Chiefs at Chargers
12	11/27/22	9:25 pm	vs LAR Rams Los Angeles Rams	KC -16.0	LAR +800/KC -1250	O/U 42.0	26-10	9 - 2	Chiefs vs Rams
13	12/4/22	9:25 pm	at CIN Bengals Cincinnati Bengals	KC -2.5	KC -145/CIN +125	O/U 53.5	24-27	9 - 3	Chiefs at Bengals
14	12/11/22	9:05 pm	at DEN Broncos Denver Broncos	KC -9.0	KC -435/DEN +350	O/U 44.0	34-28	10 - 3	Chiefs at Broncos
15	12/18/22	6:00 pm	at HOU Texans Houston Texans	KC -14.0	KC -975/HOU +675	O/U 48.5	30-24	11 - 3	Chiefs at Texans
16	12/24/22	6:00 pm	vs SEA Seahawks Seattle Seahawks	KC -10.0	SEA +400/KC -500	O/U 50.0	24-10	12 - 3	Chiefs vs Seahawks
17	1/1/23	6:00 pm	vs DEN Broncos Denver Broncos	KC -12.5	DEN +540/KC -740	O/U 46.0	27-24	13 - 3	Chiefs vs Broncos
18	1/7/23	9:30 pm	at OAK Raiders Las Vegas Raiders	KC -9.0	KC -435/OAK +350	O/U 52.0	31-13	14 - 3	Chiefs at Raiders
	POSTSEASON
2	1/21/23	9:30 pm	vs JAX Jaguars Jacksonville Jaguars	KC -9.5	JAX +390/KC -490	O/U 52.0	27-20	1 - 0	Chiefs vs Jaguars