San Francisco 49ers Schedule 2022 San Francisco 49ers Schedule

The 49ers play in the NFC West and face the AFC West this year, so they are tied for the fifth-most difficult schedule in the NFL this year. Combine that with expected growing pains for Trey Lance in his first year as a starter, and it could be a tough year for Kyle Shanahan’s team. The first two games are easy enough against the Bears (road) and Seahawks (home), but rom there it gets more difficult with two primetime games against the Broncos (road) and Rams (home). The most difficult stretch of the season comes starting in Week 7 when the Niners play the Chiefs (home), Rams (road), and Chargers (home), but they luckily have their bye week between those Rams and Chargers matchups. The final four weeks of the season set up nicely with the Seahawks (road), Commanders (home), Raiders (road), and Cardinals (home), and if Lance gets better as the year goes on that late-season stretch could catapult the 49ers into another deep playoff run.