San Francisco 49ers Schedule 2021 San Francisco 49ers Schedule

Many are calling for a Super Bowl hangover with the San Francisco 49ers as they have a division that is very tough, especially with the Cardinals making their moves over the offseason. They are in the bottom half for strength of schedule, but there are a lot of matchups that can go either way. San Francisco will start out at home facing the Arizona Cardinals, before things get a little easier. They go on the road for both of the next two weeks, as they have both the Giants and the Jets. This is not a bad road schedule to get out of the way, especially factoring in you are in the same state. San Francisco will welcome the Eagles on Sunday Night for Week 4, and then have an easy home matchup against the Dolphins next. The middle of the season is where things get tough for San Francisco, as they will go on the road against the Patriots, Seahawks, and Saints all before their Bye Week. Their home games are against the Packers and Rams. Coming out of the bye week they face the Rams and then are at home against the Bills. Week 15 is going to be circled as they face the Cowboys, and then have the Cardinals and Seahawks on the schedule.