San Francisco 49ers Schedule 2021 San Francisco 49ers Schedule

0-0, T-1st NFC West

@ DET

5:00 pm GMT , 9/12

Many are calling for a Super Bowl hangover with the San Francisco 49ers as they have a division that is very tough, especially with the Cardinals making their moves over the offseason. They are in the bottom half for strength of schedule, but there are a lot of matchups that can go either way. San Francisco will start out at home facing the Arizona Cardinals, before things get a little easier. They go on the road for both of the next two weeks, as they have both the Giants and the Jets. This is not a bad road schedule to get out of the way, especially factoring in you are in the same state. San Francisco will welcome the Eagles on Sunday Night for Week 4, and then have an easy home matchup against the Dolphins next. The middle of the season is where things get tough for San Francisco, as they will go on the road against the Patriots, Seahawks, and Saints all before their Bye Week. Their home games are against the Packers and Rams. Coming out of the bye week they face the Rams and then are at home against the Bills. Week 15 is going to be circled as they face the Cowboys, and then have the Cardinals and Seahawks on the schedule.

Date Time Opponent Stadium Record Opponent Depth Chart 49ers Depth Chart Matchup
9/12/21 5:00 pm at Detroit Lions Detroit Lions Ford Field 0 - 0 Detroit Lions Lions San Francisco 49ers 49ers San Francisco 49ers 49ers at Detroit Lions Lions
9/19/21 5:00 pm at Philadelphia Eagles Philadelphia Eagles Lincoln Financial Field 0 - 0 Philadelphia Eagles Eagles San Francisco 49ers 49ers
9/27/21 12:20 am vs Green Bay Packers Green Bay Packers Levi's Stadium 0 - 0 Green Bay Packers Packers San Francisco 49ers 49ers
10/3/21 8:05 pm vs Seattle Seahawks Seattle Seahawks Levi's Stadium 0 - 0 Seattle Seahawks Seahawks San Francisco 49ers 49ers
10/10/21 8:25 pm at Arizona Cardinals Arizona Cardinals U of Phoenix Stadium 0 - 0 Arizona Cardinals Cardinals San Francisco 49ers 49ers
10/25/21 12:20 am vs Indianapolis Colts Indianapolis Colts Levi's Stadium 0 - 0 Indianapolis Colts Colts San Francisco 49ers 49ers
10/31/21 5:00 pm at Chicago Bears Chicago Bears Soldier Field 0 - 0 Chicago Bears Bears San Francisco 49ers 49ers
11/7/21 9:25 pm vs Arizona Cardinals Arizona Cardinals Levi's Stadium 0 - 0 Arizona Cardinals Cardinals San Francisco 49ers 49ers
11/16/21 1:15 am vs Los Angeles Rams Los Angeles Rams Levi's Stadium 0 - 0 Los Angeles Rams Rams San Francisco 49ers 49ers
11/21/21 6:00 pm at Jacksonville Jaguars Jacksonville Jaguars TIAA Bank Field 0 - 0 Jacksonville Jaguars Jaguars San Francisco 49ers 49ers
11/28/21 9:25 pm vs Minnesota Vikings Minnesota Vikings Levi's Stadium 0 - 0 Minnesota Vikings Vikings San Francisco 49ers 49ers
12/6/21 1:20 am at Seattle Seahawks Seattle Seahawks Lumen Field 0 - 0 Seattle Seahawks Seahawks San Francisco 49ers 49ers
12/12/21 6:00 pm at Cincinnati Bengals Cincinnati Bengals Paul Brown Stadium 0 - 0 Cincinnati Bengals Bengals San Francisco 49ers 49ers
12/19/21 9:05 pm vs Atlanta Falcons Atlanta Falcons Levi's Stadium 0 - 0 Atlanta Falcons Falcons San Francisco 49ers 49ers
12/24/21 1:20 am at Tennessee Titans Tennessee Titans Nissan Stadium 0 - 0 Tennessee Titans Titans San Francisco 49ers 49ers
1/2/22 9:05 pm vs Houston Texans Houston Texans Levi's Stadium 0 - 0 Houston Texans Texans San Francisco 49ers 49ers
1/9/22 9:25 pm at Los Angeles Rams Los Angeles Rams SoFi Stadium 0 - 0 Los Angeles Rams Rams San Francisco 49ers 49ers