San Francisco 49ers Schedule 2022 San Francisco 49ers Schedule
13-4, 1st NFC West
Final
The 49ers play in the NFC West and face the AFC West this year, so they are tied for the fifth-most difficult schedule in the NFL this year. Combine that with expected growing pains for Trey Lance in his first year as a starter, and it could be a tough year for Kyle Shanahan’s team. The first two games are easy enough against the Bears (road) and Seahawks (home), but rom there it gets more difficult with two primetime games against the Broncos (road) and Rams (home). The most difficult stretch of the season comes starting in Week 7 when the Niners play the Chiefs (home), Rams (road), and Chargers (home), but they luckily have their
| WK | Date | Time | Opponent | Spread | Moneyline | Total | Score | Record | Matchup |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 9/11/22 | 5:00 pm | at  CHI Bears Chicago Bears | SF -6.0 | SF -255/CHI +215 | O/U 38.5 | 10-19 | 0 - 1 | 49ers at Bears |
| 2 | 9/18/22 | 8:05 pm | vs  SEA Seahawks Seattle Seahawks | SF -8.5 | SEA +310/SF -380 | O/U 39.5 | 27-7 | 1 - 1 | 49ers vs Seahawks |
| 3 | 9/26/22 | 12:20 am | at  DEN Broncos Denver Broncos | SF -1.5 | SF -120/DEN +100 | O/U 45.0 | 10-11 | 1 - 2 | 49ers at Broncos |
| 4 | 10/4/22 | 12:15 am | vs  LAR Rams Los Angeles Rams | SF -2.0 | LAR +100/SF -120 | O/U 42.0 | 24-9 | 2 - 2 | 49ers vs Rams |
| 5 | 10/9/22 | 8:05 pm | at  CAR Panthers Carolina Panthers | SF -6.0 | SF -250/CAR +210 | O/U 39.5 | 37-15 | 3 - 2 | 49ers at Panthers |
| 6 | 10/16/22 | 5:00 pm | at  ATL Falcons Atlanta Falcons | SF -4.0 | SF -200/ATL +170 | O/U 46.0 | 14-28 | 3 - 3 | 49ers at Falcons |
| 7 | 10/23/22 | 8:25 pm | vs  KC Chiefs Kansas City Chiefs | KC -1.0 | KC -115/SF -105 | O/U 48.5 | 23-44 | 3 - 4 | 49ers vs Chiefs |
| 8 | 10/30/22 | 8:25 pm | at LAR Rams Los Angeles Rams | LAR -1.0 | SF -105/LAR -115 | O/U 42.0 | 31-14 | 4 - 4 | 49ers at Rams |
| 9 | BYE WEEK | ||||||||
| 10 | 11/14/22 | 1:20 am | vs  LAC Chargers Los Angeles Chargers | SF -8.0 | LAC +275/SF -330 | O/U 45.5 | 22-16 | 5 - 4 | 49ers vs Chargers |
| 11 | 11/22/22 | 1:15 am | at  ARI Cardinals Arizona Cardinals | SF -9.5 | SF -410/ARI +330 | O/U 43.0 | 38-10 | 6 - 4 | 49ers at Cardinals |
| 12 | 11/27/22 | 9:25 pm | vs  NO Saints New Orleans Saints | SF -8.5 | NO +330/SF -410 | O/U 43.5 | 13- | 7 - 4 | 49ers vs Saints |
| 13 | 12/4/22 | 9:05 pm | vs  MIA Dolphins Miami Dolphins | SF -5.0 | MIA +195/SF -230 | O/U 46.0 | 33-17 | 8 - 4 | 49ers vs Dolphins |
| 14 | 12/11/22 | 9:25 pm | vs  TB Buccaneers Tampa Bay Buccaneers | SF -3.5 | TB +150/SF -175 | O/U 38.5 | 35-7 | 9 - 4 | 49ers vs Buccaneers |
| 15 | 12/16/22 | 1:15 am | at SEA Seahawks Seattle Seahawks | SF -3.0 | SF -175/SEA +150 | O/U 42.5 | 21-13 | 10 - 4 | 49ers at Seahawks |
| 16 | 12/24/22 | 9:05 pm | vs  WAS Commanders Washington Commanders | SF -6.0 | WAS +250/SF -300 | O/U 37.0 | 37-20 | 11 - 4 | 49ers vs Commanders |
| 17 | 1/1/23 | 9:05 pm | at  OAK Raiders Las Vegas Raiders | SF -10.0 | SF -490/OAK +390 | O/U 41.0 | 37-34 | 12 - 4 | 49ers at Raiders |
| 18 | 1/8/23 | 9:25 pm | vs ARI Cardinals Arizona Cardinals | SF -14.0 | ARI +675/SF -975 | O/U 40.5 | 38-13 | 13 - 4 | 49ers vs Cardinals |
| POSTSEASON | |||||||||
| 1 | 1/14/23 | 9:30 pm | vs SEA Seahawks Seattle Seahawks | SF -9.5 | SEA +370/SF -460 | O/U 42.0 | 41-23 | 1 - 0 | 49ers vs Seahawks |
| 2 | 1/22/23 | 11:30 pm | vs  DAL Cowboys Dallas Cowboys | SF -3.5 | DAL +170/SF -200 | O/U 46.5 | 19-12 | 2 - 0 | 49ers vs Cowboys |
| 3 | 1/29/23 | 8:00 pm | at  PHI Eagles Philadelphia Eagles | PHI -3.0 | SF +135/PHI -155 | O/U 45.0 | 7-31 | 2 - 1 | 49ers at Eagles |
