San Francisco 49ers Schedule 2021 San Francisco 49ers Schedule

2-3, 0 NFC West

vs IND

12:20 am GMT , 10/25

Sun, 1:30p
Sun, 1:30p
MIA
Dolphins
JAX
Jaguars

Many are calling for a Super Bowl hangover with the San Francisco 49ers as they have a division that is very tough, especially with the Cardinals making their moves over the offseason. They are in the bottom half for strength of schedule, but there are a lot of matchups that can go either way. San Francisco will start out at home facing the Arizona Cardinals, before things get a little easier. They go on the road for both of the next two weeks, as they have both the Giants and the Jets. This is not a bad road schedule to get out of the way, especially factoring in you are in the same state. San Francisco will welcome the Eagles on Sunday Night for Week 4, and then have an easy home matchup against the Dolphins next. The middle of the season is where things get tough for San Francisco, as they will go on the road against the Patriots, Seahawks, and Saints all before their Bye Week. Their home games are against the Packers and Rams. Coming out of the bye week they face the Rams and then are at home against the Bills. Week 15 is going to be circled as they face the Cowboys, and then have the Cardinals and Seahawks on the schedule.

Date Time Opponent Stadium Record Opponent Depth Chart 49ers Depth Chart Matchup
10/25/21 12:20 am vs Indianapolis Colts Indianapolis Colts Levi's Stadium 2 - 3 Indianapolis Colts Colts San Francisco 49ers 49ers San Francisco 49ers 49ers vs Indianapolis Colts Colts
10/31/21 5:00 pm at Chicago Bears Chicago Bears Soldier Field 2 - 3 Chicago Bears Bears San Francisco 49ers 49ers San Francisco 49ers 49ers at Chicago Bears Bears
11/7/21 9:25 pm vs Arizona Cardinals Arizona Cardinals Levi's Stadium 2 - 3 Arizona Cardinals Cardinals San Francisco 49ers 49ers San Francisco 49ers 49ers vs Arizona Cardinals Cardinals
11/16/21 1:15 am vs Los Angeles Rams Los Angeles Rams Levi's Stadium 2 - 3 Los Angeles Rams Rams San Francisco 49ers 49ers San Francisco 49ers 49ers vs Los Angeles Rams Rams
11/21/21 6:00 pm at Jacksonville Jaguars Jacksonville Jaguars TIAA Bank Field 2 - 3 Jacksonville Jaguars Jaguars San Francisco 49ers 49ers San Francisco 49ers 49ers at Jacksonville Jaguars Jaguars
11/28/21 9:25 pm vs Minnesota Vikings Minnesota Vikings Levi's Stadium 2 - 3 Minnesota Vikings Vikings San Francisco 49ers 49ers San Francisco 49ers 49ers vs Minnesota Vikings Vikings
12/6/21 1:20 am at Seattle Seahawks Seattle Seahawks Lumen Field 2 - 3 Seattle Seahawks Seahawks San Francisco 49ers 49ers San Francisco 49ers 49ers at Seattle Seahawks Seahawks
12/12/21 6:00 pm at Cincinnati Bengals Cincinnati Bengals Paul Brown Stadium 2 - 3 Cincinnati Bengals Bengals San Francisco 49ers 49ers San Francisco 49ers 49ers at Cincinnati Bengals Bengals
12/19/21 9:05 pm vs Atlanta Falcons Atlanta Falcons Levi's Stadium 2 - 3 Atlanta Falcons Falcons San Francisco 49ers 49ers San Francisco 49ers 49ers vs Atlanta Falcons Falcons
12/24/21 1:20 am at Tennessee Titans Tennessee Titans Nissan Stadium 2 - 3 Tennessee Titans Titans San Francisco 49ers 49ers San Francisco 49ers 49ers at Tennessee Titans Titans
1/2/22 9:05 pm vs Houston Texans Houston Texans Levi's Stadium 2 - 3 Houston Texans Texans San Francisco 49ers 49ers San Francisco 49ers 49ers vs Houston Texans Texans
1/9/22 9:25 pm at Los Angeles Rams Los Angeles Rams SoFi Stadium 2 - 3 Los Angeles Rams Rams San Francisco 49ers 49ers San Francisco 49ers 49ers at Los Angeles Rams Rams