The Bills open up the season with a couple of divisional games, and in the AFC East, that is not a bad thing. While the Jets and Miami are set to improve a tad, the Bills are near favorites to take the division for the first time in years. The Bills will welcome the Los Angeles Rams in Week 3, which is an advantage for them getting them to travel across the country. However they will go out to Las Vegas the week after, and then play Tennessee on the road. A big Thursday Night game is Kansas City traveling to Buffalo. A couple of divisional games will follow going on the road to face the Jets and then back at home for New England. The Bills have another tough game, but once again they will be at home to face the Seahawks. Before the Bye Week, the Bills will go to Arizona. After the Bye Week, the Bills take on some extremely tough defenses. They will face the Chargers at home, before going the on the road to face the San Francisco 49ers. The stretch of facing the Steelers, Broncos, and Patriots is tough before a home game to finish the 2020 season against Miami.