Buffalo Bills Schedule 2021 Buffalo Bills Schedule

4-1, 0 AFC East

@ TEN

12:15 am GMT , 10/19

Sun, 1:30p
Sun, 1:30p
MIA
Dolphins
JAX
Jaguars

The Bills open up the season with a couple of divisional games, and in the AFC East, that is not a bad thing. While the Jets and Miami are set to improve a tad, the Bills are near favorites to take the division for the first time in years. The Bills will welcome the Los Angeles Rams in Week 3, which is an advantage for them getting them to travel across the country. However they will go out to Las Vegas the week after, and then play Tennessee on the road. A big Thursday Night game is Kansas City traveling to Buffalo. A couple of divisional games will follow going on the road to face the Jets and then back at home for New England. The Bills have another tough game, but once again they will be at home to face the Seahawks. Before the Bye Week, the Bills will go to Arizona. After the Bye Week, the Bills take on some extremely tough defenses. They will face the Chargers at home, before going the on the road to face the San Francisco 49ers. The stretch of facing the Steelers, Broncos, and Patriots is tough before a home game to finish the 2020 season against Miami.

Date Time Opponent Stadium Record Opponent Depth Chart Bills Depth Chart Matchup
10/19/21 12:15 am at Tennessee Titans Tennessee Titans Nissan Stadium 4 - 1 Tennessee Titans Titans Buffalo Bills Bills Buffalo Bills Bills at Tennessee Titans Titans
10/31/21 5:00 pm vs Miami Dolphins Miami Dolphins Highmark Stadium 4 - 1 Miami Dolphins Dolphins Buffalo Bills Bills Buffalo Bills Bills vs Miami Dolphins Dolphins
11/7/21 6:00 pm at Jacksonville Jaguars Jacksonville Jaguars TIAA Bank Field 4 - 1 Jacksonville Jaguars Jaguars Buffalo Bills Bills Buffalo Bills Bills at Jacksonville Jaguars Jaguars
11/14/21 6:00 pm at New York Jets New York Jets MetLife Stadium 4 - 1 New York Jets Jets Buffalo Bills Bills Buffalo Bills Bills at New York Jets Jets
11/21/21 6:00 pm vs Indianapolis Colts Indianapolis Colts Highmark Stadium 4 - 1 Indianapolis Colts Colts Buffalo Bills Bills Buffalo Bills Bills vs Indianapolis Colts Colts
11/26/21 1:20 am at New Orleans Saints New Orleans Saints Caesars Superdome 4 - 1 New Orleans Saints Saints Buffalo Bills Bills Buffalo Bills Bills at New Orleans Saints Saints
12/7/21 1:15 am vs New England Patriots New England Patriots Highmark Stadium 4 - 1 New England Patriots Patriots Buffalo Bills Bills Buffalo Bills Bills vs New England Patriots Patriots
12/12/21 9:25 pm at Tampa Bay Buccaneers Tampa Bay Buccaneers Raymond James Stadium 4 - 1 Tampa Bay Buccaneers Buccaneers Buffalo Bills Bills Buffalo Bills Bills at Tampa Bay Buccaneers Buccaneers
12/19/21 6:00 am vs Carolina Panthers Carolina Panthers Highmark Stadium 4 - 1 Carolina Panthers Panthers Buffalo Bills Bills Buffalo Bills Bills vs Carolina Panthers Panthers
12/26/21 6:00 pm at New England Patriots New England Patriots Gillette Stadium 4 - 1 New England Patriots Patriots Buffalo Bills Bills Buffalo Bills Bills at New England Patriots Patriots
1/2/22 6:00 pm vs Atlanta Falcons Atlanta Falcons Highmark Stadium 4 - 1 Atlanta Falcons Falcons Buffalo Bills Bills Buffalo Bills Bills vs Atlanta Falcons Falcons
1/9/22 6:00 pm vs New York Jets New York Jets Highmark Stadium 4 - 1 New York Jets Jets Buffalo Bills Bills Buffalo Bills Bills vs New York Jets Jets