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Best Bet: U217.5 (-108) at DraftKings
Score Prediction: Sixers 110, Celtics 107
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21+. Gambling Problem? Call 1-800-GAMBLER or 1-800-MY-RESET
The Pick: Sixers 110, Celtics 107
We’ll take the Under based on head-to-head data along with both the Celtics and 76ers 2026 O/U stats entering the game.
Game Betting Analysis
It’s hard not to take the Under here, with the 76ers dominate Under run to begin the 2026 season which includes a 1-4 O/U mark inside Xfinity Mobile Arena this season. The Under has hit in eight of 10 meetings with the Celtics, who own a solid Under mark in 2026 as well. While the Sixers enter this game with a 3-8 O/U record this season, the Celtics enter with a 2-8 O/U mark which includes it’s last six games overall. Boston has won eight straight games against the Eastern Conference and is the surprising road favorite here, so we’ll pass on that – as the Sixers have won three straight against the Celtics while covering five of six spreads.
Celtics-76ers Odds (Spread, Moneyline, Over/Under)
Deciding Factor: Jaylen Brown’s Revenge-Game Scoring Burst vs. Boston’s Lost Wing Defense
Tuesday’s game at Xfinity Mobile Arena (8 p.m. ET, NBC/NBC Sports Boston) is the first meeting that counts between Jaylen Brown and the franchise that traded him to Philadelphia in July — Boston sent its 2024 Finals MVP to the Sixers for Paul George, and tonight Brown gets his real reunion game after preseason didn’t count. He’s thrived in the new context: 22.3 points, 6.7 rebounds and 4.0 assists a night on 47.7% shooting from the floor and a career-best 39.2% from three, plugged into a Philadelphia attack that’s 9-2 and sitting a half-game clear of Boston atop the East. He’s not alone — Tyrese Maxey leads the Sixers at 26.9 a game, Joel Embiid is averaging 17.9 points and 9.7 rebounds over his first nine while managing plantar fasciitis (he isn’t even on tonight’s injury report, with the Sixers expected to be at full strength at the position), and LeBron James, who signed in Philadelphia as a free agent this past offseason, is chipping in 15.6 points, 7.1 rebounds and 6.7 assists as a secondary ballhandler. That’s four players capable of winning a possession off the dribble, and Brown’s personal stake in beating his old team only sharpens the motivation behind a matchup that already tilts toward Philadelphia’s shot creation.
Boston, meanwhile, is paying for the other side of that July trade. Swapping Brown’s size and point-of-attack defense for George’s shooting left the Celtics without their best answer for a wing scorer, and George — who’s averaging 20.4 points and just dropped 27 with five threes in Sunday’s win over Milwaukee — is a shooting upgrade but not the two-way stopper Brown was. That puts more defensive responsibility on Derrick White (12.9 points, 5.3 assists) against a Sixers backcourt and wing rotation that now runs three deep with shot-creators, while two-way guard Devin Carter is out sick, thinning Boston’s perimeter depth even further. Inside, Neemias Queta (9.5 points, 6.2 rebounds) is Boston’s only real rim presence against a Philadelphia frontline pairing Embiid with LeBron’s 7.1 boards a night. Jayson Tatum is playing at an MVP level himself (27.1 points, 6.0 rebounds, 7.8 assists) and has Boston on a three-game winning streak, but if Brown and LeBron are able to repeatedly force switches onto Boston’s thinned wing and center depth tonight, Philadelphia’s four-man scoring attack gives the Sixers a real path to handing the Celtics their first loss since the Brown-George swap reshaped both rosters.
Game Information
- Date: Tuesday, November 10, 2026
- Kickoff: 8:00 p.m. (ET)
- Network: NBC, Peacock
- Location: Philadelphia, Pennsylvania
- Venue: Xfinity Mobile Arena – 217.2 ppg; 1-4 O/U
Key Players
Boston Celtics
- Jayson Tatum — Last Game: 21 points, 6 assists
- Paul George — Last Game: 27 points
Philadelphia 76ers
- LeBron James — Last Game: 22 points, 5 rebounds, 5 assists
- Tyrese Maxey — Last Game: 27 points, 7 assists
Photo Credit: REUTERS
