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Kansas-Kentucky Picks, Predictions & Odds: College Basketball

Check out the college basketball game preview for Kansas vs. Kentucky with picks, predictions and odds provided by Lineups.com.
Trey Kaufman-Renn
Thom Cunningham Avatar
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Best Bet: U155.5 (-110) at DraftKings

Score Prediction: Kansas 79, Kentucky 76

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The Pick: Kansas 79, Kentucky 76

We’ll side with the Under based on numerous amount of Kansas stats paired with Kentucky’s betting data against ranked schools.


Game Betting Analysis

As it seems to be the theme for Tuesday’s games, the data is leaning towards the Under. Kentucky enters the game with a 5-10 O/U mark when facing AP ranked schools while Kansas also sports a 3-9 O/U record when facing AP ranked schools. This now steamrolls down the Jayhawks’ hill, seeing the Under hit in seven of nine games played on a neutral court. Kansas has also seen the Under hit in 11 of 15 non-conference games, while seeing 147 total points or less in 12 of 13 games when facing an AP ranked school on a neutral court at night. The Jayhawks are also 7-15 on the O/U as the favorites while going 10-21 over their last 31 regular season games in the total market department.


Kansas-Kentucky Odds (Spread, Moneyline, Over/Under)

Deciding Factor: Kansas’ Nation-Leading Defense vs. Kentucky’s Leaky Three-Point Defense

No. 15 Kansas enters Tuesday’s Champions Classic matchup with Big 12-best numbers across the board defensively, and that’s the foundation of a 2-0 start built on a +37.0 scoring margin. The Jayhawks are averaging 16.0 assists, 8.5 steals and 6.5 blocks per game — all league-leading figures — while shooting 60.3% from the field behind Tre White (15.5 ppg, 63.2% FG, an absurd 55.6% from three) and Trey Kaufman-Renn (13.0 ppg on 11-of-13 shooting). Freshman Tyran Stokes is already chipping in 11.5 points and 6.0 rebounds, giving Bill Self a deep, multi-threat roster even after losing assists leader Melvin Council Jr. (10.0 apg, tied for the team lead with 5 steals) to a broken foot suffered Monday that will keep him out of this game and into Big 12 play. Kansas’s defensive versatility — not just one player, but a unit forcing turnovers and protecting the rim at a national-leading clip — is built to exploit exactly the kind of lapse Kentucky showed in its last outing.

Kentucky, meanwhile, needed a second-half 15-3 run just to escape an 89-80 win over James Madison, a game that was tied 39-39 at halftime largely because the Dukes hoisted 45 three-pointers and made 15 of them (33%), repeatedly finding clean perimeter looks against Kentucky’s defense. The Wildcats’ own shooting has been inconsistent too — Milan Momcilovic erupted for 24 points on 6-of-9 from deep in his debut against Manhattan, then managed just 7 points on a quiet night against James Madison — and Kentucky committed 7 turnovers in each of its first two games while shooting a combined 36% from three as a team. Zoom Diallo and Alex Wilkins (16 points each against James Madison) and Malachi Moreno (8 points, 7 rebounds, 2 blocks) give Mark Pope a solid core, but a defense that let an unranked mid-major hang around into the final 10 minutes now faces a Kansas team shooting 36.4% from deep as a group with multiple high-volume three-point threats. If Kentucky’s perimeter defense doesn’t tighten up dramatically from what James Madison exposed, Kansas’s shooters have every opportunity to turn this into the kind of rout that’s defined the Jayhawks’ first two games.

Game Information

  • Date: Tuesday, November 10, 2026
  • Kickoff: 9:30 p.m. (ET)
  • Network: ESPN, ESPN+
  • Location: Chicago, Illinois
  • Venue: United Center – n/a

College Basketball Game Trends & Odds

Key Players

Kansas Jayhawks

  • Trey Kaufman-Renn — Last Game: 17 points
  • Tyran Stokes — Last Game: 8 points, 5 rebounds

Kentucky Wildcats

  • Zoom Diallo — Last Game: 16 points
  • Alex Wilkins — Last Game: 16 points

Photo Credit: REUTERS

About the Author
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Thom Cunningham is the Lineups.com News Editor. He has worked in sports media for almost two decades as a content producer, including roles at Spectrum, VegasInsider.com, Oddschecker and VSiN. Over the last decade he has focused on the sports betting and gaming space, tracking insights and data analytics and covering markets from the NFL to the Oscars. His MLB picks are also graded by DailyOverlay, which ranks industry experts.

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