Mariners vs. Yankees MLB Game Preview, Picks & Odds for Wednesday, August 12, 2026

The New York Yankees and Seattle Mariners face off on Wednesday night, with the latter looking to keep it’s playoff hopes alive with a win. Let’s dive into the betting trends, odds, data and insights for tonight game from Yankee Stadium.

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Mariners vs. Yankees MLB Game Betting Analysis

We’ll lean with the run line in this one, as the Yankees have both the data and value to consider for the RL market against Seattle. Firstly, the Yankees have covered three straight games against the Mariners. Going further back, New York is actually 8-3 on the RL over its last 11 games against Seattle. Five of those eight covers saw New York as the favorite as well. While the run line is risky for some when selecting the favorite, the run total might have another option.

The Under has actually hit in three of the last four meetings between both clubs, while the Yankees have also hit the Under in seven of eight home games when playing as favorites. So while our better bet is the run line based on the value given, playing it safer with the run total is also acceptable based on the data given.

Mariners vs. Yankees MLB Game Best Bet, Pick & Prediction

Best Bet: NYY -1.5 (+159)
Best Bet: SEA/NYY U8.5 (-102) at DraftKings
Score Prediction: Yankee 5, Mariners 3

Mariners vs. Yankees MLB Game Odds

Mariners vs. Yankees MLB Game Information

• Date: Wednesday, August 12, 2026
• Time: 7:00 p.m. ET
• Network: ESPN
• Location: Bronx, New York
• Venue: Yankee Stadium – 8.8 runs per game; 25-28-3 O/U

Mariners vs. Yankees MLB Game Betting Resources

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Mariners vs. Yankees MLB Game Key Players

Mariners

• Randy Arozarena – Last Game: 1-4, HR, RBI, R
• Dominic Canzone– Last Game: 1-3, BB
• Brendan Donovan – Last Game: 1-3

Yankees

• Trent Grisham – Last Game: 2-4, 2 RBI, 2B
• Luis Garcia Jr. – Last Game: 2-4, R, 2 2B
• Jazz Chisholm Jr. – Last Game: 1-3, R, BB

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Photo Credit: REUTERS