Pirates vs. Brewers MLB Game Preview, Picks & Odds for Wednesday, August 5, 2026

We have an NL Central battle ahead of us on Wednesday night with the Milwaukee Brew Crew taking on the Pittsburgh Pirates. Let’s go through the betting odds, data, trends and insights for this divisional game.

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Pirates vs. Brewers MLB Game Betting Analysis

The Under seems to be our top play based on a few data points, mainly the Brewers hitting the Under in their last five games. The Under has also hit in three of four meetings between Pittsburgh and Milwaukee, while the Brew Crew also owns a 25-33 O/U record at home this season. To add to Under convictions, the NRFI has also hit in six straight home games for Milwaukee when facing the Pirates.

Seven runs or less have been scored in three of the last four meetings between the two clubs, including five of the last seven game overall for Pittsburgh. Paul Skenes also takes the mound for Pittsburgh, as he has recorded seven or more strikeouts in his last four starts. If looking away from the total, however, feel free to try Pittsburgh as the Pirates have beaten the Brewers in four of the last five meetings. With that said, Pittsburgh has lost its last 10 games in Milwaukee when playing on a Wednesday, so we stay in the total market for our best play.

Pirates vs. Brewers MLB Game Best Bet, Pick & Prediction

Best Bet: PIT/MIL U7 (-103) at DraftKings
Score Prediction: Pirates 4, Brewers 2

Pirates vs. Brewers MLB Game Odds

Pirates vs. Brewers MLB Game Information

• Date: Wednesday, August 5, 2026
• Time: 7:30 p.m. ET
• Network: ESPN
• Location: Milwaukee, Wisconsin
• Venue: American Family Field – 8.6 runs per game; 25-33 O/U

Pirates vs. Brewers MLB Game Betting Resources

• MLB Betting Trends
• MLB Starting Lineups
• MLB Team Stats
• MLB Player Stats

Pirates vs. Brewers MLB Game Key Players

Pirates

• Brandon Lowe – Last Game: 2-4, R
• Jake Mangum– Last Game: 1-3, BB
• Endy Rodriguez – Last Game: 1-3, HR, RBI, R, BB

Brewers

• Jackson Chourio – Last Game: 3-4, HR, 2 RBI, R
• Brice Turang – Last Game: 1-5
• William Contreras – Last Game: 2-4, R

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Photo Credit: REUTERS