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Padres vs. Brewers Game 2 Picks, Predictions & Odds: MLB Playoffs Divisional Series

Get our Padres vs. Brewers Game 2 picks, predictions and betting odds for the NLDS with insights provided by Lineups.com.
Chourio
Thom Cunningham Avatar
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Best Bet: U7.5 (-120) at Hard Rock Bet

Score Prediction: Brewers 4, Padres 3

The Pick: Brewers 4, Padres 3

We’ll take the Under based on head-to-head data along with Milwaukee’s stats in the playoffs.

Game Betting Analysis

We got burnt in Game 1 with the Over, so we’ll go to the Under as the Brewers have now hit the Under in seven straight playoff games. The Under has also cashed in four of six meetings between both clubs, while the Brew Crew also own a 35-43-4 O/U record at home this season. The home team has now won five straight games between both clubs as well, with the Brewers winning seven straight games as the favorite. San Diego covers, though, covering 10 straight games as an underdog when coming off a loss – while also covering four straight run lines against the Brewers. Those markets are too expensive to back, so we’re handcuffed to the Under.

MLB Game Trends & Betting Data

Padres vs. Brewers Odds (Spread, Moneyline, Over/Under)

Deciding Factor: Michael King’s Playoff Pedigree vs. Logan Henderson’s October Unknown

San Diego is already facing a must-win after Milwaukee’s wild 3-2 Game 1 finish — Jackson Chourio’s two-run homer and a William Contreras solo shot were enough to hold off the Padres, with Trevor Megill closing it out and a roof-assisted ninth-inning out sealing it. Lose Game 2 and the Padres head back to Petco Park down 0-2 against a Brewers team that just posted a franchise-record 103 wins, the best mark in baseball, while San Diego limped into October as a 90-71 Wild Card team, 13 games back in the NL West. That gap in regular-season quality makes today’s pitching matchup carry even more weight than usual.

That’s where Michael King becomes the biggest factor on the mound for either side. He’s 12-10 with a 3.21 ERA this season but turns into a different pitcher in October, with a 2.05 career postseason ERA and a no-hitter carried into the seventh inning during the Wild Card Series. Milwaukee counters with Logan Henderson, whose regular-season numbers are arguably better on paper — a 2.47 ERA, 110 strikeouts in 98.1 innings, a 0.84 WHIP and a .183 opponent average — but the 24-year-old has zero prior October starts and missed time this year with a forearm injury. King has been here before and been dominant; Henderson hasn’t been here at all. If the Padres are going to even this series, it likely starts with King matching his playoff track record against a Brewers lineup that’s deeper and more battle-tested than San Diego’s own.

Game Information

  • Date: Sunday, October 4, 2026
  • Kickoff: 4:00 p.m. ET
  • Network: FS1
  • Venue: American Family Field – 9 runs per game; 35-43-3
  • Series Score: Brewers 1-0

MLB Playoffs Betting Central

Key Players

San Diego Padres

  • Manny Machado — Last Game: 2/4, 2B, BB
  • Fernando Tatis Jr. — Last Game: 1/5

Milwaukee Brewers

  • Jackson Chourio — Last Game: 1/4, HR, 2 RBI, R
  • William Contreras — Last Game: 1/3, HR, RBI, R, BB

Photo Credit: REUTERS

About the Author
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Thom Cunningham is the Lineups.com News Editor and has been involved with sports media for almost two decades at Spectrum, VegasInsider.com, Oddschecker, VSiN and much more as a content producer - focused on the betting and gaming space over the last decade tracking insights, data analytics and covering various markets from the NFL to the Oscars. 

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