Vegas Golden Knights vs. Colorado Avalanche Game 2 Preview, Picks & Odds for Friday, May 22, 2026

The Vegas Golden Knights were able to take Game 1, up a break on the Colorado Avalanche entering Game 2. Can Colorado even the series, or will the Avs hit the road down 2-0 to the Golden Knights? Let’s go through the betting odds, data, insights and trends for Friday’s Game 2 from the Ball Arena in Devner, Colorado.

Vegas Golden Knights vs. Colorado Avalanche Betting Analysis

Vegas isn’t a terrible look with a current  five-game winning streak when playing on the road, but Colorado is very good in a bounce back spot winning six straight off a loss. As an underdog, Vegas is solid too with wins in four of five games in the role – also covering the puck line in 13 straight road games as an underdog. The goal total pushed in Game 1, as the Under has now hit in nine of 10 home games for Colorado when facing Vegas – the one non-Under being Game 1’s push.

There are a lot of good looks in the player prop market, Brett Howden particularly who extended his goal streak in Game 1 to six straight road games. Pavel Dorofeyev, our player prop pick in Game 1, also hit a goal to see his streak extend to four straight games. Nathan MacKinnon is still minus-value for a goal, scoring in six of seven games. Valeri Nichushkin is also a good look, +390 odds and scoring in four of five home games when facing Vegas.

Vegas Golden Knights vs. Colorado Avalanche Best Bet, Pick & Prediction

Best Bet: Valeri Nichushkin Anytime Goal (+390)
Score Prediction: Avalanche 4, Golden Knights 3

Vegas Golden Knights vs. Colorado Avalanche Game Odds

Vegas Golden Knights vs. Colorado Avalanche Game Information

  • Date: Friday, May 22, 2026
  • Time: 8:10 p.m. ET
  • Network: ESPN
  • Location: Denver, Colorado
  • Venue: Ball Arena – 6.5 goals per game; 21-23-3 O/U
  • Series Score: Golden Knights 1-0

Vegas Golden Knights vs. Colorado Avalanche Betting Resources

Vegas Golden Knights vs. Colorado Avalanche Key Players

Vegas Golden Knights

  • Pavel Dorofeyev – Last Game: (1 Goal, 0 Assists)
  • Brett Howden – Last Game: (1 Goal, 0 Assists)
  • Jack Eichel – Last Game: (0 Goals, 1 Assist)

Colorado Avalanche

  • Nathan MacKinnon – Last Game: (0 Goals, 1 Assist)
  • Valeri Nichushkin – Last Game: (1 Goal, 0 Assists)
  • Gabriel Landeskog – Last Game: (1 Goal, 0 Assists)

Photo Credit: AP/David Zalubowski

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Thom Cunningham is the Lineups.com News Editor and has been involved with sports media for almost two decades at Spectrum, VegasInsider.com, Oddschecker, VSiN and much more as a content producer - focused on the betting and gaming space over the last decade tracking insights, data analytics and covering various markets from the NFL to the Oscars. 

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