Dolphins Vs. 49ers Preview (12/4/22): Betting Odds, Prediction, Depth Chart

The 8-3 Miami Dolphins travel to Levi stadium to face off against the 7-4 San Francisco 49ers in a battle between 49ers’ head coach Kyle Shanahan and his prodigy Mike McDaniel, the Dolphins’ head coach, on Sunday. With playoff seeding on the line, don’t expect these old friends to go easy on each other though. With that, let’s look at the odds, preview, prediction, injuries, key matchup, and depth charts to see who is the actual underdog in this one. 

Miami Dolphins vs San Francisco 49ers Odds

The Miami Dolphins are +4 point underdogs against the -4 San Francisco 49ers. The Dolphins are +155 on the money-line, while the 49ers reside at -180. The over/under is set at 46.5 points. 

Miami Dolphins vs San Francisco 49ers Preview & Prediction

With a strong showing in the first half of last week’s game and with a long road trip west ahead, Mike McDaniel rested his starters for the majority of second half after getting out to a 30-0 lead against the 1-7-1 Houston Texans (final score: 30-15) last week. It was another well rounded game by Miami, whose offense continued its impressive 30+ point streak (4) and its defense recorded 5 sacks, 7 tackles-for-loss, 1 pick, and 1 strip-sack touchdown. While it may not be the most needed rest for the first-team, it is a testament to how McDaniel views this next chunk of the Dolphins schedule. Facing playoff-contenders for the next three weeks, the Dolphins will need to bring everything they have if they plan on winning the AFC East, as the Bills lag only one game behind in the divisional race. 

The 49ers have been on a defensive tear as of late and that was no different in the team’s 13-0 shutout victory over the New Orleans Saints last Sunday. Though an ugly victory, it marked the team’s fourth straight win and another in which its defense led the way after the offense came out flat. Though the Christian McCaffrey situation is perplexing given his relative lack of production, the 49ers defense ranks 1st in the NFL and presents a formidable challenge to even the best of NFL offenses. With the Dolphins ranking 6th in total offense, this is a great match-up to watch this weekend. 

The Dolphins’ offensive line may be the key to this game. With LT Terron Armstead and RT Austin Jackson listed as questionable and doubtful respectfully, the 49ers defensive line – led by Edge rush Nick Bosa – may feast on pressuring Tua. While Tua has one of the fastest releases in the entire NFL and a league high passer rating of 115.7 (1st), he faces his toughest test yet especially if Armstead isn’t playing. 

Over on the 49ers’ offensive side, the team’s unit has struggled in recent weeks as the run game has slowed. With QB Jimmy Garoppolo limited to his comfortable game-manager role, it wouldn’t surprise me if Kyle Shanahan relied on the run-game despite the recent struggles. Shanahan will look to avoid putting Garoppolo in the same situation the QB was in the last time these two teams played, where he threw for 2 interceptions and was benched in a 43-17 loss in 2020. 

This game is going to be close and the only bet that looks appealing is the under. Factoring in the offensive line question marks on the Dolphin side and the limits of Jimmy Garoppolo on the 49ers side, expect this game to feature a ton of rushing and a ton of defense. 

Betting Trends

–Dolphins are 5-1 ATS in their last 6 games following a straight up win of more than 14 points.

–49ers are 7-2 ATS in their last 9 home games.

Key Injuries


-WR Deebo Samuel (Q)

-LT Trent Williams (Q)


-LT Terron Armstead (Q)

-RT Austin Jackson (D)

-CB Byron Jones (O)

Key Matchup

Dolphins Offensive Line Injury Report vs the 49ers Blitz

Keep the injury report handy as updated to LT Armstead could swing this line even more than its bobbling +4 to +3.5 spread price. 

Dolphins Depth Chart

QB: Tua Tagovailoa
RB1: Jeff Wilson
RB2: Raheem Mostert
LWR: Jaylen Waddle
RWR: Tyreek Hill
SWR: Cedrick Wilson
TE1: Mike Gesicki

49ers Depth Chart

QB: Jimmy Garoppolo
RB1: Christian McCaffery
RB2: Tre Mason
LWR: Deebo Samuel
RWR: Brandon Aiyuk
SWR: Jawan Jennings
TE1: George Kittle

Carson Marsh graduated from the University of Southern California with a Bachelor's Degree in Communication with special focus on Sports Media from the Annenberg School of Communication and Journalism, Carson has worked in journalism as a field reporter for, the longest-running publication exclusively dedicated to USC football and also worked in the social media department with the Las Vegas Raiders.

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