Tennessee Titans vs. Indianapolis Colts (10/2/22): Odds, Predictions, Depth Chart

Week 3 was a revenge week for the AFC South, with the Colts, Titans, and Jaguars all beating AFC West opponents. It’s clear this division could be a dogfight, and that fight continues when the Colts host the Titans on Sunday in their first of two matchups this season. Which team will make it back-to-back wins?

Let’s make predictions, dive into the depth charts, and examine the odds ahead of Sunday’s game at Lucas Oil Stadium.

Tennessee Titans vs. Indianapolis Colts Betting Odds

The Colts enter as a 3.5-point home favorite and sit at -175 on the moneyline. The over/under is set at 42.5 points.

Both teams had a combined zero wins entering Week 3 before turning the ship around against the AFC West. Either way, this is about what you could’ve expected for a Titans-Colts matchup in Indianapolis. Mike Vrabel and Frank Reich are 4-4 against each other since they were hired in 2018, indicating how closely matched these teams have been.

Tennessee Titans vs. Indianapolis Colts Prediction

The Colts look like they’re starting to find themselves. At full strength, they have the most talented roster in the division, and the defense played above expectations against the Chiefs even without Shaquille Leonard. Encouraging signs from a still-sluggish offense in Week 3 may be an indication that the Colts are about to round into form.

Matt Ryan looked more comfortable against Kansas City, finishing 27-of-37 for 222 yards and 2 touchdowns. He would ultimately engineer an 8-minute game-winning drive against the odds. The biggest difference between Week 2 and Week 3? Michael Pittman Jr.

The third year-receiver already has a strong connection with Ryan and posted 72 yards on Sunday after missing the Colts’ loss to the Jaguars. The presence of Pittman, plus the emergence of rookie Alec Pierce, allow Indianapolis to take some pressure off of Jonathan Taylor.

The Titans have plenty of talent on the defensive side of the ball, but we’ve seen vulnerabilities so far. Tennessee’s run defense was trampled by Saquon Barkley in Week 1, and Stefon Diggs had his way with the secondary in Week 2. Even in the win this past weekend, they allowed 396 yards to the Raiders.

The Titans did a great job of slowing down Taylor in their two meetings with the Colts last season, but the progress Ryan and the passing game have made leads me to believe Indianapolis has enough to pull out a comfortable home win. If Leonard is ready to make his season debut, the Colts will be in even better position.

Betting Trends

  • The Titans are 0-4 ATS in their last 4 road games. Mike Vrabel’s group lost 41-7 in its only road game so far this season
  • The Colts are 1-4 ATS in their last 5 games against AFC opponents. To their credit, that ATS win came against the Chiefs this past weekend
  • The under is 8-0 in the Colts’ last 8 games. That’s an eye-popping trend, especially in a game that looks like it will be won by whichever defense steps up

Key Injuries

Tennessee Titans Injuries: Tackle Taylor Lewan will miss the rest of the season after suffering a knee injury in Week 2. Edge rusher Bud Dupree is questionable after missing Week 3 with a hip injury. Linebacker Zach Cunningham is questionable with an elbow injury.

Indianapolis Colts Injuries: Linebacker Shaquille Leonard is questionable after missing the first three games with a back injury. Cornerback Stephon Gilmore (hamstring) and safety Julian Blackmon (ankle) are questionable after suffering injuries against Kansas City.

Key Matchups

Check out the key matchups and mismatches for Titans vs. Colts below.

Jonathan Taylor vs. Titans Run Defense

The Titans did a fine job keeping Taylor in check last season, holding him to 64 and 70 yards, respectively, in their two meetings. Considering the Titans’ offense is much more limited than last season, quieting Taylor will be the bare minimum if Tennessee wants to win.

The run defense struggled against Saquon Barkley in Week 1 but has otherwise held up fairly well. Zach Cunningham’s status will be worth monitoring heading into Sunday, as a thin linebacker group could open the door for a big day from Taylor.

Ryan Tannehill vs. Colts Secondary

The Colts’ defense has been a mixed bag this season, letting Trevor Lawrence have a big day but rebounding to quiet Patrick Mahomes a week later. When healthy, Indianapolis has the personnel in the secondary to limit passing offenses. Kenny Moore was a Pro-Bowler last season, and Stephon Gilmore was a nice veteran addition at the CB position.

With Gilmore and safety Julian Blackmon battling injuries, there could be an opportunity for Tannehill and the Titans’ passing game to deliver. A lack of receivers beyond Robert Woods might complicate that effort.

Tennessee Titans Depth Chart

QB: Ryan Tannehill
RB1: Derrick Henry
RB2: Dontrell Hilliard
RB3: Hassan Haskins
LWR: Robert Woods
RWR: Nick Westbrook-Ikhine
SWR: Treylon Burks
TE1: Austin Hooper

Indianapolis Colts Depth Chart

QB: Matt Ryan
RB1: Jonathan Taylor
RB2: Nyheim Hines
RB3: Deon Jackson
LWR: Alec Pierce
RWR: Michael Pittman Jr.
SWR: Parris Campbell
TE1: Mo Alie-Cox

Dan is a lifelong sports fan and graduate of Boston University. He’s covered several sports on Instagram since he was 12 and now writes about everything from betting trends to breaking news for Lineups.

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