MLB Home Run Predictions, Picks, Props, Odds for Tuesday, May 5, 2026

We swept the board on Monday for the first time this season, as Aaron Judge, Seiya Suzuki, and Jac Caglianone each went yard. We’ll try to build off this winning night for Tuesday’s slate.

Today, we’re riding with James Wood, Bryce Harper, and Jac Caglianone. Each of these three hitters is in favorable spots due to hitter-friendly weather.

Remember to be sure to check out our daily MLB betting trends page.

Click any odds below to place a wager. For more sportsbook promos, we highly recommend checking out the best sports betting sites.

2026 MLB HR Props Record: 19-93 (-1.37 units) 

Home Run Prop Predictions & Odds: MLB HR Best Bets for Tuesday, May 5

James Wood Home Run Odds

James Wood is currently slashing .231/.383/.507 with 10 home runs in 167 plate appearances. The 23-year-old slugger has been crushing the ball, as highlighted by a video game-like 26.3% barrel rate.

Up next is a matchup against Twins’ righty Taj Bradley, who is in the middle of a breakout season, putting up a 2.85 ERA (3.99 xERA). However, Bradley still has some issues with the long ball (1.10 HR/9), especially vs. lefties (1.23 HR/9).

To make matters worse for Bradley, we’ve got hitter-friendly weather in this one. Forecasts are calling for 80-degree temperatures with 14 MPH winds blowing out to center field.

These are the ideal conditions for Wood to snap his nine-game drought without a home run. Risk 0.1 units.

Bryce Harper Home Run Odds

Bryce Harper has been rock-solid this year, slashing .271/.362/.519 with seven home runs in 149 plate appearances. This includes an impressive 12.8% walk rate and a 16.8% strikeout rate. The batted ball metrics also look good, with a 13.3% barrel rate.

On top of that, Harper is starting to heat up the plate, homering in his last game, where he also had three hits in four plate appearances.

Up next is a matchup vs. Luis Severino. This is a terrible spot for Severino, as we’ve also got hitter-friendly weather in Philadelphia, with forecasts calling for 78-degree temperatures with 15.6 MPH winds blowing out to center.

Severino gives up a lot of hard contact (9.3% barrel rate), so there’s a chance that he could get rocked in this game, especially in a hitter’s park like in Philadelphia.

When you consider all the factors in Harper’s favor, it makes sense to take him to hit his 8th homer of the year here. Risk 0.1 units.

Jac Caglianone Home Run Odds

We’re going back to the well with Jac Caglianone after he homered for us on Monday. The 23-year-old slugger has some of the most raw power in baseball, and we’re finally starting to see the results we’ve been waiting for.

All four of Caglianone’s home runs have come in the last 12 games, with two coming in the last four. The batted ball metrics point to a hitter who just needs a tweak in launch angle to put the ball in the air more instead of on the ground. This is highlighted with his 15.2% barrel rate.

Even though Gavin Williams is a tough matchup, he’s still had a tough time with the long ball this season, including a 1.25 HR/9. As mentioned above, Caglianone can crush the ball in any conditions, even when the wind is blowing in at Kauffman Stadium.

This gives us a better price on Caglianone, so we’ll take a shot on him going yard for the second consecutive game. Risk 0.1 units.

Join Lineups’ free sports betting Discord channel, with more than 5,100 community members discussing MLB 24-7-365.

Best Sportsbook Promos For Home Run Prop Predictions

Rank
Sportsbooks
Bonus
Features
Play
1
Up to $1,500
In Bonuses
BetMGM Sportsbook Review
  • Up to $1,500 in Bonus Bets if Your First Bet Doesn't Win*

  • *Bonus Bets Expire in 7 Days. One New Customer Offer Only. Add’l terms. 21+. Gambling Problem? Call 1-800-BETS-OFF

  • Use Bonus Code: BETLINEUPS

2
Bet $10 Get $150
In Bonus Bets Win or Lose
Bet365 Sportsbook Review
  • Bet $10 Get $150 in Bonus Bets Win or Lose

  • 30% Extra on Same Game Parlay Profit

  • T&Cs Apply. GAMBLING PROBLEM? CALL 1-800-MY-RESET. 21+

  • Use Bonus Code: LINEUPSBET

3
Get $350 in Bonus Bets
When You Bet $5 for 7 Days
FanDuel Sportsbook Review
  • Get $350 in Bonus Bets Guaranteed - When You Bet $5 for 7 Days!

  • Available on Desktop, Android & iOS

  • Easy Deposits, Fast Withdrawals

4
Double Your Winnings
On Your Next 10 Wagers
Caesars Sportsbook Review
  • Bet $1, Double Your Winnings on Your Next 10 Wagers (Up to $25 Max Bet Per Boost)

  • Stream NFL Games In-App for Free

  • OH only. 21+.Gambling Problem? Call or text 1-800-MY-RESET

  • Use Promo Code: LINEUPSDYW

5
Up to $1,000
In FanCash Matched Bets
Fanatics Sportsbook Review
  • Get a 100% Bet Match up to $100 in FanCash for 10 Days

  • Earn FanCash & Spend it on Team Swag or More Bets

  • Daily Odds & Profit Boosts on Select Games

6
Bet $5 Get $200 in Bonus Bets
New User Bonus
DraftKings Sportsbook Review
  • Bet $5 Get $200 in Bonus Bets Instantly

  • Plus Get up to $1,000 Deposit Bonus

  • Bet on All Your Favorite Sports With America's Top-Rated Sportsbook

  • To Claim: Click Play Now

Photo Credit: AP/Rebecca Blackwell

Post
Frank Ammirante has been creating sports betting and fantasy sports content for 5+ years, specializing in baseball and football, but also writing about basketball, hockey, and soccer. He has also written online casino, sweepstakes casino, prediction markets, and news articles while working as a content editor as well. You may have seen his work at The Game Day, RotoBaller, FantasyPros, Deadspin, Casino.org, and much more. Frank started out in the fantasy sports space and has competed in popular industry events like Tout Wars. His work has recently been published in this year's Fantasy Index fantasy baseball magazine. As an avid Blue Jays fan, Frank is still mourning their World Series loss to the Dodgers, calling it "one of the biggest collapses in sports history."

Hot Betting News Stories

Sign up to our newsletter to get lineups latest hands-on reviews, expert advice, and exclusive offers delivered straight to your inbox.
You are already subscribed to our newsletter. Want to update your preferences data?
Thank you for signing up! You’re all set to receive the latest reviews, expert advice, and exclusive offers straight to your inbox. Stay tuned!
Something went wrong. Please try again later
Sign up to our newsletter to get lineups latest hands-on reviews, expert advice, and exclusive offers delivered straight to your inbox.
You are already subscribed to our newsletter. Want to update your preferences data?
Thank you for signing up! You’re all set to receive the latest reviews, expert advice, and exclusive offers straight to your inbox. Stay tuned!
Something went wrong. Please try again later