TCU vs. Duke Second Round Game Preview, Picks, Betting Odds & Data

By Thom Cunningham | Mar 20, 2026, 5:58pm

The Duke Blue Devils survived a scare in the First Round against the Siena Saints. They now face the TCU Horned Frogs who defeated Ohio State on Thursday’s slate. Let’s go through the betting data, trends, odds and insights to wager this East Region game.

TCU vs. Duke Game Information

Date: Saturday, Mar. 21, 2026
Time: 5:15 p.m. ET
Network: CBS
Region: East
Location: Greenville, South Carolina
Venue: Bon Secours Wellness Arena

TCU vs. Duke Betting Resources

TCU vs. Duke Betting Odds

TCU vs. Duke Betting Data

TCU Horned Frogs

Region Odds:
Sweet 16 Odds:
Elite Eight Odds:
Final Four Odds:
National Title Odds:

Seed: No. 9
Record: 23-11
Conference: Big 12
PS/G: 77.9
PA/G: 71.8
ORtg: 111
DRtg: 102.3

Duke Blue Devils

Region Odds:
Sweet 16 Odds:
Elite Eight Odds:
Final Four Odds:
National Title Odds:

Seed: No. 1
Record: 33-2
Conference: ACC
PS/G: 82
PA/G: 63.2
ORtg: 122.4
DRtg: 94.4

TCU vs. Duke Key Players

TCU Horned Frogs

Micah Robinson – Last Game: 18 points, 5 rebounds
David Punch – Last Game: 16 points, 13 rebounds, 3 blocks
Xavier Edmonds – Last Game: 16 points, 8 rebounds

Duke Blue Devils

Cameron Boozer – Last Game: 22 points, 13 rebounds
Cayden Boozer – Last Game: 19 points, 5 assists
Isaiah Evans – Last Game: 16 points, 10 rebounds

TCU vs. Duke Betting Analysis

Duke survived the outright win, but didn’t come close to covering against Siena’s +29-point spread. Duke falls to 4-5 ATS on a neutral court while also failing to cover its last two games. The Blue Devils are still 33-0 outright vs non-AP ranked schools, so following that trend the outright win shouldn’t be a concern as much as the -12-points might. Duke has dropped four of five game spreads, while TCU enters 9-3 ATS as an underdog.

The Horned Frogs are 6-2 ATS over their last eight games, also hitting the Under in four of six games.

TCU vs. Duke Best Bet, Pick & Prediction

TCU’s ATS mark, along with its Under run recently, is why we’ll side with the spread here instead of the Over. Although TCU goes Under recently, the Horned Frogs have gone Over 142 total points in four straight NCAA Tournament games. The spread seems large enough for TCU to cover, especially after watching Siena do it just two days ago. There’s just more consistency in wagering on TCU’s 6-2 ATS and 9-3 ATS as an underdog mark, paired with Duke’s 1-4 ATS skid, then there is in the total trends.

Score Prediction: Duke 77, TCU 70
Best Bet: TCU +12 (-110)

Photo Credit: AP/Chris Carlson

Thom Cunningham

Thom Cunningham is the Lineups.com News Editor and has been involved with sports media for almost two decades at Spectrum, VegasInsider.com, Oddschecker, VSiN and much more as a content producer - focused on the betting and gaming space over the last decade tracking insights, data analytics and covering various markets from the NFL to the Oscars.