Buffalo Bills vs. Miami Dolphins Preview (9/25/22): Betting Odds, Prediction, Depth Chart

It’ll be a battle of undefeated teams with high-flying offenses at Hard Rock Stadium on Sunday, with the Dolphins looking to defend their home turf against the Super Bowl favorite Buffalo Bills. Tua Tagovailoa is hoping to build off of a career performance, while the Bills will try to keep the Allen-to-Diggs connection working and take control of the AFC East.

Let’s make predictions, dive into the depth charts, and take a look at the odds ahead of Sunday’s big divisional matchup in Miami.

Buffalo Bills vs. Miami Dolphins Betting Odds

The Bills enter as 5.5-point road favorites and sit at -225 on the moneyline. The over/under is set at 54 points, higher than any other game this week.

Not many teams would be decisive favorites in Miami after what we saw this Dolphins offense do last week, but the Bills have been that good. It’s not a surprise that oddsmakers expect this to be a high-scoring affair after both of these teams scored more than 40 points in Week 2, but let’s not forget that both defenses have some serious talent.

Buffalo Bills vs. Miami Dolphins Prediction


We know Josh Allen can win anytime and anywhere. I’m not sure we’ve seen the Dolphins prove they can do the same, but the comeback in Baltimore was a step in the right direction. Plus, they don’t have to go anywhere for this game.

The Allen-to-Diggs connection has been excellent for the Bills, but the defense has been right there with it. Buffalo has allowed only 17 points this season and just might have what it takes to slow down the elite duo of Tyreek Hill and Jaylen Waddle.

Watching the Dolphins’ offense go to work has been one of the most entertaining parts of the beginning of this season, but it still hasn’t shown any signs of being two-dimensional. Miami doesn’t have an efficient running game yet, and it’s unlikely Mike McDaniel will be able to change that against a Bills defense that just bottled up Derrick Henry.

The Bills are well aware of the dangers of Hill and Waddle. I trust their defensive gameplan and powerful offense to pave the way for a win.

Betting Trends

  • The Bills are 7-1-1 ATS in their last 9 games against AFC East opponents. After years of Patriots dominance, Buffalo has owned the division.
  • The Dolphins are 6-1 ATS in their last 7 home games. Something has to give, but dating back to last year’s win streak, Miami keeps overperforming.
  • The over is 4-0 in the Bills’ last 4 games against teams with a winning record. Even with the over/under all the way at 54, it won’t be impossible for these two offenses to get there.

Key Injuries

Buffalo Bills Injuries: Receiver Gabe Davis missed the Bills’ win over the Titans with an ankle injury and will be worth monitoring. Defensive tackle Ed Oliver is questionable after missing Week 2 with an ankle injury as well. Cornerback Tre’Davious White (knee) remains out on the PUP list. Cornerback Dane Jackson and safety Micah Hyde both went to the hospital during Monday night’s game with neck injuries, and their statuses are unclear after tests didn’t reveal any major injuries.

Miami Dolphins Injuries: Tackle Austin Jackson is on IR with an ankle injury and will miss Sunday’s game. Receiver Cedrick Wilson is questionable after leaving the win over Baltimore with an ankle injury. Cornerback Byron Jones (Achilles) remains out on the PUP list.

Key Matchups

Check out the key matchups and mismatches for Steelers vs. Browns below.

Dolphins Receivers vs. Bills Secondary

Slowing down Hill and Waddle is a must for any team that wants to beat the Dolphins. It’s virtually impossible to shut both of them down, but with the offense strictly running through the two wideouts, just keeping them in check could be enough.

The Bills’ secondary has been terrific this season even without White. The uncertain statuses of Jackson and Hyde could complicate the situation, but the defense is deep enough for players to step up in their absence. Even linebacker Matt Milano ended up with a pick-six of Ryan Tannehill on Monday night. If Buffalo can force some Tua turnovers, advantage Bills.

Bills Offensive Line vs. Dolphins Pass-Rush

The Bills’ offensive line wasn’t thought to be one of the strongest areas on the roster entering the season, but the unit has held up well against a pair of tremendous talents so far. On the other hand, the Dolphins’ pass-rush has been disappointing. With only two sacks on the season, a group led by Emmanuel Ogbah and Jaelan Phillips should be making a bigger impact after a promising finish to 2021.

Miami couldn’t get to Lamar Jackson in Week 2, and Josh Allen’s mobility – while not at the level of Jackson – could make life difficult for this defense again. It’s still not impossible for the Dolphins to put some pressure on Allen, especially if Ogbah and Phillips regain last year’s late-season form.

Buffalo Bills Depth Chart

QB: Josh Allen
RB1: Devin Singletary
RB2: Zack Moss
RB3: James Cook
LWR: Stefon Diggs
RWR: Isaiah McKenzie
SWR: Gabe Davis
TE1: Dawson Knox

Miami Dolphins Depth Chart

QB: Tua Tagovailoa
RB1: Chase Edmonds
RB2: Raheem Mostert
RB3: Myles Gaskin
LWR: Jaylen Waddle
RWR: Tyreek Hill
SWR: Cedrick Wilson Jr.
TE1: Mike Gesicki

Dan is a lifelong sports fan and recent graduate of Boston University. He created @allsportsnews on Instagram when he was 12 and continues to post sports news and rankings daily.

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