Jacksonville Jaguars vs. Indianapolis Colts (10/16/2022): Betting Odds, Prediction, Depth Chart

Entering week six of the NFL season, we get an AFC South rematch from an earlier beatdown this season between the Jacksonville Jaguars and Indianapolis Colts.  The earlier week 2 was completely dominated by Jacksonville as they went on to win 24-0 and the Colts simply could find no answers offensively or defensively.  That game was played in Jacksonville, where the Colts have not been able to win since 2014.  The tides turn however, as this game is being played in Indianapolis where the Colts have been able to usually win against the Jags on their home turf.  

Since their week two game, the Jaguars have gone 1-2 in their next three.  They dominated the Chargers 38-10 and many thought the Jaguars were on the rise for a much improved season.  The following two games however resulted in losses and QB Trevor Lawrence who looked great in the first three games struggled with turnovers.  The Colts have gone 2-1 in their next three winning squeaker games against the Chiefs and Broncos but losing a tough one to the Titans.  The defense has looked great but the offense continues to struggle.  Now both teams have two wins and desperately need a third to make their argument for the division title.  Let’s break into this game’s picks and predictions.

Jacksonville Jaguars Vs. Indianapolis Colts Betting Odds


Despite dominating their last two games against the Colts, the Jaguars are underdogs in this matchup in Indianapolis.  The Colts are narrow moneyline favorites at -135 odds.  This makes sense as I’ve said while the Jaguars have had the Colts number in Jacksonville, the Colts have had the Jags in Indy.  The Jaguars are also still a young and rebuilding team while the Colts were expected to be a win now and have much higher season expectations.  That doesn’t mean much if QB Matt Ryan and the offensive line can’t get anything going.  The spread line -2.5 points in favor of the Colts but initially opened at -7, which means favors are moving in the Jaguars way.  Most likely due to that week two game in which the Jaguars owned the Colts in every way, but the Colts have slowly improved from the game while the Jaguars are starting to show expected mistakes.

The over/under total line is currently 42 points.  A lot of the numbers would say the Under would be a smart bet considering the Colts have hit the Under in every game they’ve played this year.  The Jaguars have shown their ability to score though, and we will have to wait and see if the Colts can find offensive production at home.

Jacksonville Jaguars Vs. Indianapolis Colts Picks & Prediction

My pick: Indianapolis Colts -2 (-107)

Even with the Colts earlier loss to the Jaguars this season, I think they are able to outmatch the Jaguars defensively and get their third win of the season.  The Jaguars have started out strong but I think some of those issues that had them low-ranked preseason are starting to show with a young offense making mistakes.  The Colts offense has been the lowest scoring this season out of all NFL teams averaging 13.8 per game.  I think this game will allow Matt Ryan to gain more confidence with his offense coming off a win and the O-Line more of a chance to get structured to its new core.

Betting Trends

  • The Jaguars are 5-1-1 ATS in their last seven games in Indianapolis
  • The Jaguars are also 1-6 ATS in their last seven road games
  • The Colts are 5-1 ATS in their last six games when they let up less than 15 points in the previous game
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Key Injuries

Jacksonville Jaguars:

K’Lavon Chaisson, IR

Ben Bartch, IR

Folorunso Fatukasi, questionable

Indianapolis Colts:

Julian Blackmon, questionable

Tyquan Lewis, questionable

Shaquille Leonard, questionable

Jonathan Taylor, questionable

Ashton Dulin, IR

Colts vs Juguars Key Matchups

How will Trevor Lawrence fare against a ballhawking Colts secondary?

Trevor Lawrence vs. Indianapolis Colts Defense

The major matchup I have my eye on is Trevor Lawrence vs. the Indy defense.  The Indy defense was able to hold Patrick Mahomes and the Chiefs to under 20 points and held the Broncos and Russell Wilson to less than 10.  Lawrence had a strong start and threw for 2 TDs and over 200 yds against the Colts in week two.  The past two weeks though he has struggled, throwing for 2 INTs last weekend and having a league-high 4 fumbles in a game against the Eagles.  I expect the Colts defense will possibly force some more for him this week.

Jacksonville Jaguars Depth Chart

QB: Trevor Lawrence
RB1: James Robinson
RB2: Travis Etienne Jr.
RB3: Snoop Conner
LWR: Marvin Jones Jr.
RWR: Christian Kirk
SWR: Zay Jones
TE1: Evan Engram

Indianapolis Colts Depth Chart

QB: Matt Ryan
RB1: Jonathan Taylor
RB2: Nyheim Hines
RB2: Deon Jackson
LWR: Alec Pierce
RWR: Michael Pittman Jr.
SWR: Parris-Campbell
TE1: Mo Alie-Cox

Jack is a sports media graduate from Indiana University with a strong expertise in all things sports. A background in sports radio and writing, his favorite pastime is debating hot sports takes. While some people may know him for his opiniated stances, he'll always have an argument to back it up. Just like how Hoosiers is the best sports film of all time without debate!

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