Tennessee Titans vs Buffalo Bills Preview (9/19/22): Betting Odds, Prediction, Depth Chart

The Tennessee Titans are headed to Buffalo for their first primetime game of the season on Monday Night Football. After the Giants upset the Titans in week 1, they will compete against Buffalo in a battle of two of last year’s best AFC teams. The Titans defeated the Bills 34-31 in last season’s regular season matchup, but much has changed for both teams since that week 6 contest. Let’s examine the matchups, odds, injuries, and depth charts that will determine how this year’s game will fare.

Tennessee Titans Vs. Buffalo Bills Betting Odds


The (-9.5) Bills are heavily favored to beat the (+9.5) Titans. Despite the Titans earning the AFC #1 seed last season, the odds point to a big Bills win after they embarrassed the defending champion Rams last week and showed why they are the offseason favorite for the Super Bowl. The over/under opened at 50, but has since moved down to 49.5.

Tennessee Titans Vs. Buffalo Bills Prediction

After blowing a 13 point lead and losing to the Giants, the Titans face one of the league’s toughest opponents to rebound from their loss. Many have predicted the Titans to regress from the AFC’s #1 seed last season after Ryan Tannehill’s rough playoff game with three costly interceptions and the team trading star receiver AJ Brown to the Eagles. Their loss to the Giants did little to counter this doubt. Still, the Titans have reigning coach of the year in Mike Vrabel, who helped the Titans reach the playoffs even when they were one of the most injured teams ever. If any coach is built to overcome a challenge, it’s Vrabel.

The Bills come into this game with a lot of confidence after blowing out the reigning super bowl champions 31-10. Despite some early game mistakes with two of Josh Allen’s passes being intercepted and a James Cook fumble, the Bills had no problems taking care of the Rams. The Bills big free agent signing, Von Miller, proved successful with two sacks in the opening game. This helped the Bills pass rush looked better than ever, as they were able to pressure quarterbck Matt Stafford only rushing four defenders. In addition, their playmakers showed up with WR Stefon Diggs putting up 122 yards and a touchdown and Gabe Davis contributing 88 yards with a touchdown.

More than anything, the Titans have to worry about quarterback Josh Allen. Josh Allen showed once again last Thursday why he is a top quarterback in the league. From stiff-arming Nick Scott, reaching over the end zone “Space Jam” style for a rush touchdown, to hurling a 50 yard touchdown to Diggs, there’s no way I’m betting against Josh Allen. Still, I anticipate the Titans to keep the game close and not allow the Bills to cover the spread.


Prediction: Bills 34-28, Over hits

Betting Trends

Titans are 8-2 ATS in their last 10 Monday games.
Titans are 6-2 ATS in their last 8 games as an underdog.
Bills are 4-0-1 ATS in their last 5 games as a favorite.

Key Injuries

Tennessee Tians Injuries: Lonnie Johnson (Groin) Q, Jamarco Jones (Triceps) Q, Ola Adeniyi (Shoulder) Q, A.J. Moore (Ankle) O

Buffalo Bills Injuries: Tommy Doyle (Foot) Q, Quintin Morris (Hamstring) Q, Ed Oliver (Ankle) Q

Key Matchups

Check out the key matchups and mismatches for away team vs home team below.

Derrick Henry vs Bills Rush Defense

It’s no secret that the Titans do not exactly have the strongest receiving corps ever assembled. With AJ Brown playing for Philadelphia, Robert Woods coming off an injury and Treylon Burks needing to time emerge in his rookie season, the Titans best chance for offensive explosion is star running back Derrick Henry. Henry, who ran for 82 yards on 21 carries versus the Giants, will need to step up against the Bills to provide an offensive threat for the Titans. Getting the run game going will also allow the Titans to drain the clock and keep Josh Allen off the field. However, that’s easier said than done. The Bills run defense is no easy foe as they limited the Rams’ Darrell Henderson to 47 yards at 3.6 yards per carry.

Josh Allen vs Titans Secondary

Whether it’s running through defenders like he’s injury-proof or throwing lasers to his weapons, there may be no player who leaves it all on the field like Josh Allen. For the Titans to stay close in this game, they need to stay on the Bills receivers and leave no room for Allen to fit the ball in. The Titans did a good job of limiting quarterback Daniel Jones to 188 passing yards this past Sunday, but he still completed 17/21 of his passes. Josh Allen is a much tougher opponent to say the least. If the Titans aren’t able to prevent Allen’s completions and he starts out with ten straight completions like he did versus the Rams, the odds for a Titans victory will become slim.

Tennessee Titans Depth Chart

QB: Ryan Tannehill
RB1: Derrick Henry
RB2: Dontrell Hilliard
LWR: Robert Woods
RWR: Nick Westbrook-Ikhine
SWR: Treylon Burks
TE1: Austin Hooper

Buffalo Bills Depth Chart

QB: Josh Allen
RB1: Devin Singletary
RB2: Zack Moss
LWR: Gabriel Davis
RWR: Stefon Diggs
SWR: Isaiah McKenzie
TE1: Dawson Knox

I am a senior at UCLA majoring in Communication. My football addiction started when I bought a Madden game in fifth grade to fit in with my older brothers. Ten years and many Redzone Sundays later, my brothers still ignore me, except for when they need fantasy football advice

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