Week 16 NFL Predictions: DraftKings Pick6 Strategy (Sunday, December 21)
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We’re moving on to Week 16 of the 2025 NFL season, with no shortage of intriguing matchups to target for the DraftKings6 slate.
These contests combine stat projections into a single lineup. Simply build a lineup of projections by selecting whether they will have more or less than their projected output. You must have at least two from the same sport (as you cannot combine Picks from other sports), but this column focuses on the NFL.
With that in mind, let’s break down my selections for Week 16 NFL for DraftKings Pick6.
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Week 16 NFL Selections: DraftKings Pick6 (Sunday, December 21)
Green Bay Packers QB Jordan Love: More Than 232.5 Passing Yards
Jordan Love is on a roll right now, throwing for 234+ yards in three consecutive games. This includes 276 in a loss against a tough Broncos defense in Week 15.
Up next is a rematch vs. the Bears. When these teams met in Week 14, Love threw for 234 yards on only 25 attempts, averaging 9.36 yards per attempt, which is an elite number.
This time, the game is on the road, and Josh Jacobs is banged up for the Packers. That could result in more passing volume compared to the previous meeting, making more than 232.5 passing yards look like an appealing play.
Philadelphia Eagles WR A.J. Brown: More Than 63.5 Receiving Yards
A.J. Brown has been effective for the Eagles down the stretch, putting up 110, 132, 100, and 41 yards in his last four games. The Commanders have one of the worst defenses in the NFL, ranking 25th in receiving yards to wideouts this season.
When Brown faced the Commanders last year, he put up 97 and 65 yards, going more than this number in each matchup.
With how well Brown is playing lately, this exploitable matchup at a low number for receiving yards looks enticing.
Buffalo Bills RB James Cook: More Than 87.5 Rushing Yards
James Cook is averaging 101.1 rushing yards per game this season. The Bills’ dynamic back has put up 88+ yards on the ground in three of his last four games.
This includes 107 against a tough Patriots defense, 144 vs the Steelers, and 116 vs the Texans. Up next is a matchup vs the Browns, who have struggled to defend the run lately.
Cleveland just allowed D’Andre Swift to go off for 98 yards on 18 carries. Before that, Tony Pollard put up 161 yards on 25 attempts. With that in mind, for Cook to eclipse this high bar vs. the Browns.
DraftKings Pick6 Week 16 NFL: Terms & Conditions
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