Buffalo Bills vs. New Orleans Saints Matchup Preview (11/25/21): Betting Odds, Depth Charts, Live Stream (Watch Online)

Buffalo Bills vs. New Orleans Saints Matchup Preview (11/25/21)

The Buffalo Bills head to New Orleans to take on the Saints this Thursday for a primetime Thanksgiving matchup. Both teams are coming off egregious losses to the .500 Colts and to the 4-6 Eagles. Josh Allen and the Bills did not live up to their defensive potential on Sunday and their special teams unit was a liability. The Saints defense was also off; they gave up 242 rushing yards to the Eagles, the most all season by far. They are now on a three-game losing streak, with their schedule only getting harder as they take on the Bills this week and the Cowboys the following week. For two teams known for their strong defense, both defenses allowed at least 40 points last week, and their offense didn’t get much better, as both Josh Allen and Trevor Siemian threw two interceptions. 

Buffalo Bills vs. New Orleans Saints Betting Odds

The Bills are the 4.5-point favored team in this matchup with the over/under set at 46.5. The Bills are 5-4-1 against the spread, and the Saints are 5-5 against the spread, which makes this an intriguing game. The Bills have been relatively inconsistent this year – unable to not only not cover a -7 point spread against the Colts, but get blown out, while being able to kill the Jets the week before, covering a -13.5 spread easily. The Saints on the other hand are 4-0 in covering the over in the last four weeks, which is partly because of how many points they have given up. The Saints were plagued by some key injuries last week, and if that changes this week, then I think they can put up some points against the Bills defense. Regardless, I think the Bills offense may come out firing on all cylinders with Allen at the helm which will be more than Siemian can match against a strong defensive line. 

My prediction: 32-21 Bills win, Bills cover, over 46.5 points

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TV Schedule

Date: November 25th, 2021
Time: 8:20 PM ET
Location: Caesars Superdome – New Orleans, LA
TV Coverage: NBC

Buffalo Bills vs. New Orleans Saints Live Stream

Where can you watch Bills vs. Saints online? You can stream this game, and many other NFL games live online with Hulu. Hulu has a 7 Day free trial and is cheaper than cable options at $5.99/month. Watch Bills vs. Saints Free Online Now.

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Buffalo Bills Analysis

Let’s face it: last week was not pretty. Jonathan Taylor put the Bills rush defense on skates with five touchdowns and 185 rushing yards. The Bills entered the game with 5 rushing touchdowns against them all season, and Taylor added 4 to that in last Sunday’s game alone. They were missing Tremaine Edwards which undoubtedly would have helped their run defense. Aside from a struggling rush defense, the Bills proved last week that turnovers were also an issue. Allen threw two interceptions, and Isaiah Mckenzie fumbled a kick return that was eventually returned for a Colts touchdown. First and foremost, they need to come back this week and learn how to take care of the football if they want a result, especially now that they’ve dropped to #2 in the AFC East. 

But, the Bills are not a lost cause. Josh Allen is still one of the best in the league with 2,811 passing yards on the season. Against a strong rush defense like the Saints, their best bet is to use Allen’s arm and exploit New Orleans’ mediocre pass defense. Targets like Stefon Diggs and Emmanuel Sanders will need to come up big in this game, which I predict they will. Diggs had a pair of touchdowns against the Colts despite only being targeted 6 times for 23 yards. 

As far as the Bills defense goes, they can really only go up from last week (hopefully). Their defense suffered without Tremaine Edwards who is likely out for this Sunday’s game as well, so they will need to look to find a new strategy that doesn’t involve him. Even with last week’s poor defensive performance, the Bills defense remains first in total yards and total passing yards against and if the Saints’ injury train continues with Siemian at the helm and no Alvin Kamara, it gives the Bills a leg up in proving their defensive potential.

Buffalo Bills Depth Chart

QB: Josh Allen
RB1: Zack Moss
RB2: Devin Singletary
WR1: Stefon Diggs
WR2: Emmanuel Sanders
WR3: Cole Beasley
TE1: Dawson Knox
TE2: Tommy Sweeney

New Orleans Saints Analysis

The Saints are on a three-game losing streak and are currently plagued by key injuries which is not necessarily grounds for success going forward, especially against the Bills and the Cowboys over the next two weeks. Last week, Jalen Hurts ran the ball into the Saints endzone three times against their defense despite being recognized as one of the top rushing defenses in the league. 

Offensively, the Saints really showed no offensive threats against the Eagles, when Siemian was at the Helm without Kamara or offensive tackles Ryan Ramczyk and Terron Armstead. Siemian struggled to find a real offensive rhythm and had two interceptions, one of which was a pick-six, which secured the Eagles’ win. With Siemian being unpredictable, the Saints may keep the ball on the ground in the hands of Mark Ingram who rushed for 88 yards over 16 attempts last game. Ingram has rushed for 499 yards this season and is the best rushing threat that the Saints pose against the Bills defense if Kamara does not return. He is currently questionable for a return in this week’s game due to a knee injury. 

If the Saints don’t have Kamara, I foresee offensive struggles for the Saints, especially against a strong Bills defense, however, Ingram shouldn’t be written off as he has proved to be another solid option. Their game plan will likely surround Ingram since they don’t have much in the way of receiving threats, and they will likely rely heavily on their defense to perform well. 

The Saints are currently .500 on the season after last week’s loss and they have the Carolina Panthers on their heels in the NFC South at 5-6. The Panthers play Miami this week which realistically should be a win for them, so if the Saints don’t get a result here, their playoff chances will start to diminish.

New Orleans Saints Depth Chart

QB: Trevor Siemian
RB1: Alvin Kamara
RB2: Mark Ingram
WR1: Marquez Callaway
WR2: Deonte Harris
WR3: Tre’Quan Smith
TE1: Adam Trautman
TE2: Juwan Johnson

Buffalo Bills vs. New Orleans Saints Daily Fantasy Picks

Mark Ingram may be a good pick for this week depending on Kamara’s status. If Kamara is out and Siemian is unpredictable, he will likely get a lot of carries that could rack up some fantasy points. He averaged 5.5 yards per carry last game and 88 yards total. 

Stefon Diggs is another good option, as he proved last week that he can score when given the opportunity. The Bills will likely look to target him to bypass the Saints rush defense.

Week 12 Matchup Previews
  • Patriots @ Falcons
  • Colts @ Bills
  • Ravens @ Bears
  • Lions @ Browns
  • Texans @ Titans
  • Vikings @ Packers
  • Dolphins @ Jets
  • Saints @ Eagles
  • Washington @ Panthers
  • 49ers @ Jaguars
  • Bengals @ Raiders
  • Cowboys @ Chiefs
  • Cardinals @ Seahawks
  • Steelers @ Chargers
  • Giants @ Buccaneers
Mia Fowler is a graduate of Chapman University where she studied business marketing and journalism and played on the women’s soccer team. Following her 16-year journey with soccer, she started writing for Lineups.com. Her favorite sport to watch and write about is football but she also enjoys soccer, baseball, and basketball.

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