San Francisco 49ers vs. Philadelphia Eagles Matchup Preview (9/19/21): Betting Odds, Depth Charts, Live Stream (Watch Online)

San Francisco 49ers vs. Philadelphia Eagles Matchup Preview (9/19/21)

The Niners will play their second straight road game, this one in Philadelphia, after a scare against the Lions in Detroit. The Lions almost made a shocking fourth-quarter comeback that would have been a “shot heard ‘round the NFL.” Meanwhile, the Philadelphia Eagles are coming off of a massive win on the road against the Atlanta Falcons by a score of 32-6. The momentum favors the Eagles as the Niners had a rough first week and lost their starting running back Raheem Mostert and cornerback Jason Verrett. Philadelphia looked poised, mature, and dominated in the air and on the ground. San Francisco will have to play much harder on both sides of the ball to beat this aggressive, fearless Eagles team this week.

San Francisco 49ers vs. Philadelphia Eagles Betting Odds

San Francisco looked very beatable against the Detroit Lions. There are several reasons for this, but we can start by pointing out that head coach Kyle Shanahan seemed to punish running back Trey Sermon and wide receiver Brandon Aiyuk for some reason. Aiyuk ended the game with zero targets while Sermon did not even suit up. Shanahan insists that Sermon was just outplayed, and Aiyuk is still recovering from injury, but something feels awry in San Francisco. The Niners only beat the Lions by eight points and allowed them to score 33 points, which is a mindboggling amount for a pathetic excuse of an offense.

On the other hand, the Philadelphia Eagles looked rock solid. They slaughtered the Falcons 32-6 on the road. Beating the Falcons, of course, is not a rare accomplishment for an NFL team; however, it is still impressive for a team that is not projected to win many games. It is hard to decide whether the Eagles’ performance indicates their talent or their opponent’s weakness. Regardless, the apparent turmoil in San Francisco is a bit too much to ignore, especially considering it barely beat the measly Detroit Lions.

My Predictions: San Francisco 49ers win 30-27, Philadelphia Eagles cover (+4.5)

US States with Legal Sports Gambling

TV Schedule

Date: Sunday, September 19
Time: 1:00 PM ET
Location: Lincoln Financial Field – Philadelphia, PA
TV Coverage: FOX

San Francisco 49ers vs. Philadelphia Eagles Live Stream

Where can you watch 49ers vs. Eagles online? You can stream this game and many other NFL games live online with Hulu. Hulu has a 7 Day free trial and is cheaper than cable options at $5.99/month. Watch 49ers vs. Eagles Free Online Now.

hulu free trial


San Francisco 49ers: RB Raheem Mostert (Knee) Out For Season. CB Jason Verrett (Knee) Out, WR Jalen Hurd (Knee) Out, WR Brandon Aiyuk (Hamstring) Questionable, CB Emmanuel Moseley (Knee) Questionable, DT Javon Kinlaw (Knee) Questionable

Philadelphia Eagles: TE Zach Ertz (Hamstring) Questionable, G Brandon Brooks (Knee), OL Landon Dickerson (Knee) Questionable, S Rodney McLeod (Knee) Questionable

San Francisco 49ers Analysis

The San Francisco 49ers let the Detroit Lions creep a little too close in their Week 1 matchup, which ended 41-33. The Niners benched Trey Sermon and lost Raheem Mostert to a knee injury that will sideline him for the entirety of the 2021 season in the first half of the contest. While the Niners led most of the way, seeing how many points they let the Lions put on them was discouraging, especially in the last quarter. Starting quarterback Jimmy Garoppolo went for 314 yards and one passing touchdown against this weak Lions defense while running back Elijah Mitchell took full advantage of his opportunity and rushed for 104 yards. Mitchell will likely start in Week 2 against the Eagles and should fare pretty well.

The main concern for the Niners is how many points they let the Lions drop on them. Detroit may not score in the 30s for the rest of the season, yet the Niners allowed this to happen in the first week. They looked sloppy at times on both sides of the ball, especially late in the game when Deebo Samuel, who otherwise had an outstanding game, fumbled. At one point, the Niners led 38-10 and were then outscored 23-3 from that point. They will have to have a solid mental fortitude against the Eagles and avoid any second-half collapses to win.

San Francisco 49ers Depth Chart

QB: Jimmy Garoppolo
RB1: Elijah Mitchell
RB2: Trey Sermon
WR1: Deebo Samuel
WR2: Brandon Aiyuk
WR3: Mohamed Sanu Sr
TE1: George Kittle
TE2: Jordan Matthews

Philadelphia Eagles Analysis

The Philadelphia Eagles stomped on the Atlanta Falcons in their first game by a score of 32-6. Quarterback Jalen Hurts threw for 264 yards and three touchdowns with no interceptions. Additionally, he completed over 77% of his passes on his way to a 126.4 passer rating. The backfield of Kenneth Gainwell and Miles Sanders proved that it was strong with a combined 24 rushes for 111 yards and a touchdown. They also had some significance in the passing game catching six receptions for 45 yards combined.

Philadelphia looked like a completely different team than last year. The Eagles certainly have an outside shot at winning this home game against a discombobulated Niners team and an even better chance at covering the spread. If the Eagles can take their offensive and defensive momentum into Week 2, they may secure the home win.

Philadelphia Eagles Depth Chart

QB: Jalen Hurts
RB1: Miles Sanders
RB2: Kenneth Gainwell
WR1: Devonta Smith
WR2: Jalen Reagor
WR3: Travis Fulgham
TE1: Dallas Goedert
TE2: Zach Ertz

San Francisco 49ers vs. Philadelphia Eagles Daily Fantasy Picks

Elijah Mitchell impressed everyone in his first game with the surprise injury to Raheem Mostert and healthy scratch of Trey Sermon. Mitchell ran for over 100 yards on less than 20 attempts. While this was all done against the Lions’ sad excuse for a defense, it is still impressive. In recent years, the Niners have been a typically “run first” team, so Mitchell holds a lot of value on the road against the Eagles. He will have plenty of touches this game as well, considering that Mostert will be out for the rest of the 2021 season, and Sermon seemingly is in the “dog house.” If Mitchell comes with a conservative price tag, then you should pull the trigger.

The Lions were surprisingly efficient against the Niners in the air in their Week 1 home game. Jared Goff threw for 338 yards despite not having very viable receiving options. Jalen Hurts has to be licking his chops right now for the opportunity to face the same defense. If Goff can throw for 338 yards and three touchdowns on a pitiful Lions team, then I have a hard time believing Jalen Hurts could not do the same. Plus, Hurts lit up the Falcons’ defense in Week 1 for 264 yards and three touchdowns while only throwing 35 times. If Hurts is not too expensive, he may be a good play in Week 2.

Week 2 Matchup Previews
Andrew has watched sports since as young as he can remember and was fortunate enough to play college basketball. As a kid, he would sneak his Space Jam Michael Jordan jersey into his pre-school so he could wear it every day. Mom was not a happy camper when she found out.

Hot NFL Matchup Previews Stories